Two Episodes of Carbamazepine-Induced Severe Thrombocytopenia in the Same Child

Casasín, Tomás; Allende, Ana Vivanco; Maciá, M.; Güell, Rosa

doi:10.1177/106002809202600523

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…In contrast, thrombocytopenia is distinctly uncommon. To our knowledge, only 23 cases of CBZ-induced thrombocytopenia have been reported since 1968; 17 patients are summarized in Table I [2][3][4][5][6][7][8][9][10][11][12][13][14][15] and hematological data were incompletely described for 6 patients [16]. The thrombocytopenia most often develops 2 weeks after initiation of CBZ treatment and recovers within 1 week after discontinuation of CBZ [11,13].…”

Section: Introductionmentioning

confidence: 99%

Carbamazepine-induced thrombocytopenia defined by a challenge test

et al. 1999

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Carbamazepine (CBZ), a widely used anticonvulsant, occasionally causes serious hematologic disorders. A 12-year-old boy was admitted because of a diffuse petechial rash and profound thrombocytopenia (10 × 10 9 platelets/l), after having been treated for epilepsy with CBZ for 12 days. Seven days following withdrawal of CBZ and initiation of prednisolone therapy, the platelet count recovered. In a subsequent challenge test with CBZ, platelet counts again decreased, and the levels of platelet-associated IgG and serum interleukin-6 increased. No antibodies against platelet glycoprotein IIb/IIIa or Ib were detected in plasma. We believe that this is the first reported occasion when CBZ-induced thrombocytopenia has been defined by a rechallenge test. Am. J. Hematol. 64:52-55, 1999.

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Section: Introductionmentioning

confidence: 99%

Carbamazepine-induced thrombocytopenia defined by a challenge test

et al. 1999

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“…Kannan et al also reported significantly more blood loss during spinal surgery in children with neuromuscular scoliosis compared to those with idiopathic scoliosis ( n = 25) and found reduced factor VII activity ( 238 ). Children with CP are also often taking medication which can effect coagulation, as reported in several case reports, such as valproate ( 239 , 240 ), carbamazepine ( 241 ), and azithromycin ( 242 ). Therefore, consideration of coagulopathy and thrombophilia in children with CP is important, particularly prior to surgery, including the administration of prophylactic tranexamic acid and early use of blood products ( 44 ).…”

Section: The Hematological Systemmentioning

confidence: 99%

Multi-Organ Dysfunction in Cerebral Palsy

et al. 2021

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Cerebral Palsy (CP) describes a heterogenous group of non-progressive disorders of posture or movement, causing activity limitation, due to a lesion in the developing brain. CP is an umbrella term for a heterogenous condition and is, therefore, descriptive rather than a diagnosis. Each case requires detailed consideration of etiology. Our understanding of the underlying cause of CP has developed significantly, with areas such as inflammation, epigenetics and genetic susceptibility to subsequent insults providing new insights. Alongside this, there has been increasing recognition of the multi-organ dysfunction (MOD) associated with CP, in particular in children with higher levels of motor impairment. Therefore, CP should not be seen as an unchanging disorder caused by a solitary insult but rather, as a condition which evolves over time. Assessment of multi-organ function may help to prevent complications in later childhood or adulthood. It may also contribute to an improved understanding of the etiology and thus may have an implication in prevention, interventional methods and therapies. MOD in CP has not yet been quantified and a scoring system may prove useful in allowing advanced clinical planning and follow-up of children with CP. Additionally, several biomarkers hold promise in assisting with long-term monitoring. Clinicians should be aware of the multi-system complications that are associated with CP and which may present significant diagnostic challenges given that many children with CP communicate non-verbally. A step-wise, logical, multi-system approach is required to ensure that the best care is provided to these children. This review summarizes multi-organ dysfunction in children with CP whilst highlighting emerging research and gaps in our knowledge. We identify some potential organ-specific biomarkers which may prove useful in developing guidelines for follow-up and management of these children throughout their lifespan.

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Acquired disorders affecting megakaryocytes and platelets

Newland¹,

MacCallum²

2011

Blood and Bone Marrow Pathology

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Two Episodes of Carbamazepine-Induced Severe Thrombocytopenia in the Same Child

Cited by 4 publications

References 3 publications

Carbamazepine-induced thrombocytopenia defined by a challenge test

Carbamazepine-induced thrombocytopenia defined by a challenge test

Multi-Organ Dysfunction in Cerebral Palsy

Acquired disorders affecting megakaryocytes and platelets

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