Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS

Yang, Xiaohang; Seow, Kah Tong; Bahri, Sami M.; Oon, Swee Huat; Chia, William

doi:10.1016/0092-8674(91)90062-4

Cited by 165 publications

(78 citation statements)

References 40 publications

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“…Both actions were associated with Src pTyr-527 dephosphorylation and increased Src activity (21,22). In addition, overexpression of PTP␣ enhanced the development of neurotransmitter response during neuronal differentiation (23), and an up-regulated expression of PTP␣ was observed during differentiation of embryonic stem cells into a neuronal phenotype (24).…”

mentioning

confidence: 94%

The Differentiation of Skeletal Muscle Cells Involves a Protein-tyrosine Phosphatase-α-mediated C-Src Signaling Pathway

Shah

Ennis

et al. 2002

Journal of Biological Chemistry

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mentioning

confidence: 94%

The Differentiation of Skeletal Muscle Cells Involves a Protein-tyrosine Phosphatase-α-mediated C-Src Signaling Pathway

Shah

Ennis

et al. 2002

Journal of Biological Chemistry

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“…This would increase the combinatorial binding possibilities among Ig/FNIII-like proteins. Furthermore, it would enable the Ig/FNIII-like molecules to interact with other axonal proteins that contain FNIII-like domains in their extracellular region like the recently discovered tyrosine phosphatases (Tian et al, 1991;Yang et al, 1991). In the best studied case, however, binding of the 10th FNIII repeat in fibronectin occurs through the tripeptide Arg-Gly-Asp sequence to a protein belonging to the integrins (Ruoslahti, 1988).…”

Section: Modulation Of the Function Of The Ig/fnlli-like Proteins On mentioning

confidence: 99%

Regulation of axonal growth in the vertebrate nervous system by interactions between glycoproteins belonging to two subgroups of the immunoglobulin superfamily.

Sonderegger

Rathjen

1992

The Journal of Cell Biology

152

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“…The LAR protein is found in many adult human tissues where it is expressed mainly in epithelial cells (Streuli et al, 1992). In the fruit fly Drosophila melanogaster, however, DLAR, an LAR-related receptor tyrosine phosphatase, is specifically expressed in the developing central nervous system (Tian et al, 1991;Hariharan et al, 1991;Yang et al, 1991). Very little is known about the PTPG gene and its protein product.…”

Section: Introductionmentioning

confidence: 99%

Two closely related receptor‐type tyrosine phosphatases are differentially expressed during rat lung development

Katsura

Williams

Brody

et al. 1995

Developmental Dynamics

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Transmembrane protein tyrosine phosphatases (PTPases) comprise a newly identified class of receptor-like molecules. In most cases their ligands and the substrates they dephosphorylate are not known. In order to begin to explore the functions of the PTPases in cell physiology and in mammalian development, we examined the expression patterns of two closely related receptor-type tyrosine phosphatase genes, namely LAR and PTPG, in fetal rat lung and in selected adult rat tissues. In the lung, in situ hybridization and immunohistochemistry show that the LAR mRNA and protein are expressed exclusively in the epithelium. In the early embryonic or fetal lung (day 13 to 18) LAR is expressed by all of the epithelial cells of the forming bronchial tree. This widespread pattern of expression is lost later in fetal Life (day 21) as the lung matures and acquires the morphologic and biochemical features of the adult organ. LAR gene expression is then confined to two epithelial progenitor cells of the distal airways, namely the bronchiolar Clara cell and the alveolar type I1 cell. The LAR gene products were also found abundantly expressed in epithelial progenitor cells of adult esophagus, skin, and small intestine, all of which are continuously renewing epithelia. The rat PTPG gene, on the other hand, is specifically expressed in the mesenchyme of the developing lung. The level of the PTPG mRNA decreases as the lung matures. These results suggest that the two closely related receptor-type tyrosine phosphatases are differentially expressed in a tissue-specific fashion. They are expressed mostly in proliferating cells or in cells which have potential to proliferate. Therefore, one function of the two receptor-like tyrosine phosphatases may be to regulate proliferation and/or differentiation of different types of cells during development, during normal cell turnover, and during adult tissue repair.

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Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS

Cited by 165 publications

References 40 publications

The Differentiation of Skeletal Muscle Cells Involves a Protein-tyrosine Phosphatase-α-mediated C-Src Signaling Pathway

The Differentiation of Skeletal Muscle Cells Involves a Protein-tyrosine Phosphatase-α-mediated C-Src Signaling Pathway

Regulation of axonal growth in the vertebrate nervous system by interactions between glycoproteins belonging to two subgroups of the immunoglobulin superfamily.

Two closely related receptor‐type tyrosine phosphatases are differentially expressed during rat lung development

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