Two doses of pandemic influenza A(H1N1) vaccine: Tolerability in healthy young children in the Netherlands

Klooster, T M van ‘t; Kemmeren, Jeanet M.; Melker, Hester E. de; Bondt, Patricia E. Vermeer-de; Maas, Nicoline A.T. van der

doi:10.4161/hv.7.10.16692

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“…No estudo realizado por Bross et al 23 , a febre acometeu 56,2% dos vacinados após a primeira dose e 56,1% após a segunda, em crianças entre seis meses e quatro anos de idade. van't Klooster et al 26 identificaram a febre como evento adverso em 29,6% das crianças após a primeira vacinação e em 30,7% após a segunda. No estudo de Scheifele et al 22 , a febre foi identificada em 3,6% das crianças após a primeira vacinação e em 8,6% após a segunda.…”

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Eventos adversos pós-vacinação contra influenza pandêmica A (H1N1) 2009 em crianças

et al. 2012

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The aim of this study was to estimate the frequency of adverse events following vaccination against pandemic influenza A (H1N1) 2009 and associated factors in children from six months to two years of age (n = 156). Multivariate Cox regression was used to assess the independent associations between covariates and complaints of at least one adverse event. Strength of association was measured by hazard ratios and respective 95% confidence intervals. Following the first dose, 40.3% of parents reported one or more adverse events in their children, compared to 35.5% after the second dose. Systemic adverse events, specifically irritation, diarrhea, and fever, were more frequent than local reactions at the vaccination site. Incidence rates for adverse events in general and systemic reactions following the first dose were higher in children with concomitant illness or allergies (HR = 3.43, 95%CI: 1.34-8.77 and HR = 2.76, 95%CI: 1.11-6.89). Most events were mild. Cases of high fever, vomiting, and diarrhea prompted parents to seek care for their children at health services.

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Section: Discussionunclassified