Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

Horikawa, Kazumasa; Fuji, Kazuyuki; Fukazawa, Yuka; Shibata, Shigenobu

doi:10.1254/jphs.13170sc

Cited by 6 publications

(1 citation statement)

References 15 publications

(20 reference statements)

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“…This finding was later confirmed with the more selective 5-HT7 receptor antagonist SB-269970 (Sprouse et al, 2004 ). In vivo studies later reported the translational aspects of this cell model by demonstrating that phase advances in wheel running activity induced by 8-OH-DPAT were blocked following the administration of the 5-HT7 receptor antagonist DR-4004 in hamsters and absent in the 5-HT7 receptor knockout (KO) mouse (Ying and Rusak, 1997 ; Ehlen et al, 2001 ; Horikawa and Shibata, 2004 ; Gardani and Biello, 2008 ; Horikawa et al, 2013 ). In addition to its effects on the non-photic regulation of circadian rhythms, there is evidence that the 5-HT7 receptor may also influence photic regulation of circadian rhythms either by altering the sensitivity to light or modulating the release of serotonin (Ying and Rusak, 1997 ; Smith et al, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

Shelton

Yun

Olson

et al. 2015

Front. Behav. Neurosci.

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Recent reports have illustrated a reciprocal relationship between circadian rhythm disruption and mood disorders. The 5-HT7 receptor may provide a crucial link between the two sides of this equation since the receptor plays a critical role in sleep, depression, and circadian rhythm regulation. To further define the role of the 5-HT7 receptor as a potential pharmacotherapy to correct circadian rhythm disruptions, the current study utilized the selective 5-HT7 antagonist JNJ-18038683 (10 mg/kg) in three different circadian paradigms. While JNJ-18038683 was ineffective at phase shifting the onset of wheel running activity in mice when administered at different circadian time (CT) points across the circadian cycle, pretreatment with JNJ-18038683 blocked non-photic phase advance (CT6) induced by the 5-HT1A/7 receptor agonist 8-OH-DPAT (3 mg/kg). Since light induced phase shifts in mammals are partially mediated via the modulation of the serotonergic system, we determined if JNJ-18038683 altered phase shifts induced by a light pulse at times known to phase delay (CT15) or advance (CT22) wheel running activity in free running mice. Light exposure resulted in a robust shift in the onset of activity in vehicle treated animals at both times tested. Administration of JNJ-18038683 significantly attenuated the light induced phase delay and completely blocked the phase advance. The current study demonstrates that pharmacological blockade of the 5-HT7 receptor by JNJ-18038683 blunts both non-photic and photic phase shifts of circadian wheel running activity in mice. These findings highlight the importance of the 5-HT7 receptor in modulating circadian rhythms. Due to the opposite modulating effects of light resetting between diurnal and nocturnal species, pharmacotherapy targeting the 5-HT7 receptor in conjunction with bright light therapy may prove therapeutically beneficial by correcting the desynchronization of internal rhythms observed in depressed individuals.

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Section: Introductionmentioning

confidence: 99%

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

Shelton

Yun

Olson

et al. 2015

Front. Behav. Neurosci.

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Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy

Krystal

Mittoux

Lindstén

et al. 2021

Journal of Affective Disorders

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Disruption of running activity rhythm following restricted feeding in female mice: Preventive effects of antidepressants

Miyawaki

Araki

Yoshimura³

2015

Journal of Pharmacological Sciences

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Biological rhythms are critical in the etiology of mood disorders; therefore, effective mood disorder treatments should address rhythm disturbances. Among the variables synchronized with the light-dark cycle, spontaneous activity in rodents is useful for investigating circadian rhythms. However, previous studies have focused only on the increase of wheel-running activity under restricted feeding conditions, while little information is available on circadian rhythm of running activity. In this study, chronometrical analysis was used to assess whether circadian rhythms during wheel-running are altered by restricted feeding and affected by antidepressant drugs. Wheel revolutions were automatically recorded and analyzed using cosinor-rhythmometry in 8-week old ICR albino mice. When feeding was restricted to 1 h per day (21:00-22:00), wheel-running rhythms were reliably disrupted. Female mice exhibited marked alterations in the pattern and extent of wheel-running beginning on day 1. Subchronic treatment with imipramine or paroxetine, as well as tandospirone and (-)-DOI, prevented wheel-running rhythm disruption. Thus, altering the circadian activity rhythms of female mice on a 1-h feeding schedule may be useful for investigating disturbances in biological rhythms.

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Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

Cited by 6 publications

References 15 publications

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy

Disruption of running activity rhythm following restricted feeding in female mice: Preventive effects of antidepressants

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