Two distinct phases and mechanisms of axonal growth shown by primary vestibular fibres in the brain, demonstrated by parvalbumin immunohistochemistry

Morris, Roger J.; Beech, J. N.; Heizmann, Claus W.

doi:10.1016/0306-4522(88)90290-4

Cited by 85 publications

(62 citation statements)

References 59 publications

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“…The trajectory and location of the labeled f ibers reported here is consistent with that observed by King and Bishop (1992) for early arriving CCK+ afferents in the oppossum cerebellum and by Wassef and Sotelo (1990) for Di I labeled fibers in embryonic rat cerebellum, establishing that these fibers are in fact immature climbing fibers. The course and submergence of olivocerebellar fibers reported here is also reminiscent of that observed at parvalbumin-labeled primary vestibular fibers in the embryonic rat cerebellum (Morris et al, 1988). An exception to the relationship between the caudal olive and the medial icp is the projection from the ventrolateral outgrowth and dorsal cap to the f locculonodular lobe.…”

Section: Segregation and Trajectory Of Fibers In The Inferior Cerebelsupporting

confidence: 74%

“…If so, this relationship could provide a mechanism for the matching of olivocerebellar fiber collaterals with appropriate targets within these cell populations. Other potential sources of axon guidance include the primary vestibular fibers and monoaminergic systems, which are reported to enter the cerebellum prior to olivocerebellar fibers (Bishop et al, 1985;Morris et al, 1988). What remains to be determined is the biochemical basis of these associations.…”

Section: Discussionmentioning

confidence: 99%

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Evidence of early topographic organization in the embryonic olivocerebellar projection: A model system for the study of pattern formation processes in the central nervous system

Paradies

Eisenman

1993

Developmental Dynamics

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Many projection systems within the peripheral and central nervous system are topographically organized, and it has become increasinging clear that interactions which occur during development determine the projection patterns these systems exhibit in the adult. The olivocerebellar system was chosen as a model system for this study of afferent pattern formation because it has several characteristics which lend themselves to a study of this type. Applications of horseradish peroxidase were made to both the cerebellar primordium and to the inferior olive of embryonic and neonatal mice using an in vitro perfusion system to support the tissue during the transport period. Fibers labeled after restricted olivary applications are limited to particular mediolateral regions of the cerebellum. Similarly, olivary cells retrogradely labeled after discrete cerebellar applications are restricted to particular olivary subdivisions. The results indicate that the olivocerebellar projection displays elements of topographic organization as early as El5 and that the pattern displayed is roughly comparable to that of the adult mammal. The observed trajectories of olivocerebellar fibers and their concomitant association with both Purkinje and cerebellar nuclear cells during embryonic development suggests a role for either or both cell types in the pattern formation process. 0 1993 Wiley-Liss, Inc.

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Section: Segregation and Trajectory Of Fibers In The Inferior Cerebelsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Evidence of early topographic organization in the embryonic olivocerebellar projection: A model system for the study of pattern formation processes in the central nervous system

Paradies

Eisenman

1993

Developmental Dynamics

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“…As PV is present only in a restricted population of neurons in the brain especially in early stage of the development (14), its early expression in these nuclei (such as RTN) makes it a useful tool with which to follow their development. This study shows that PV immunoreactivity in RTN neurons appears immediately after the formation of this nucleus which occurs at E17 (5).…”

Section: Discussionmentioning

confidence: 99%

Parvalbumin immunoreactivity in the reticular thalamic nucleus of developing rats.

Seto‐Ohshima

Aoki

Semba

et al. 1989

Acta Histochem. Cytochem

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“…Initially they elongate, without branching, toward their target and form a tract (2)(3)(4)(5)(6)(7)(8). Next, parent axons in the tract emit collaterals, which penetrate target zones and form arbors therein; as development proceeds, some collaterals are eliminated, whereas others are elaborated.…”

mentioning

confidence: 99%

“…formation, are also characterized by differential rates ofaxon extension and by changes in the levels of expression of specific proteins that are shipped to the growing axon tips (2)(3)(4)(5)(6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

Target-derived influences on axon growth modes in cultures of trigeminal neurons.

Erzurumlu

Jhaveri

Takahashi

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

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Cellular and molecular signals involved in axon elongation versus collateral and arbor formation may be intrinsic to developing neurons, or they may derive from targets. To identify signals regulating axon growth modes, we have developed a culture system in which trigeminal ganglion cells are challenged by various target tissues. Embryonic day 15 (E15) rat trigeminal ganglion explants were placed between peripheral (vibrissa pad) and central nervous system targets. Normally, bipolar trigeminal ganglion cells extend one process to the vibrissa pad and another to the brainstem trigeminal complex. Under coculture conditions, the peripheral processes invade the vibrissa pad explants and form a characteristic circumfollicular pattern. Central processes of E15 ganglion cells invade many, but not all, central nervous system tissues. In isochronic (E15) central nervous system explants such as brainstem, olfactory bulb, or neocortex, these central processes elongate and form a "tract" but have virtually no arbors. However, in more mature targets (e.g., a section from postnatal brainstem or neocortex), they form arbors instead of a tract. We conclude from these observations that whether trigeminal axons elongate to form a tract, or whether they begin to arborize, is dictated by the target tissue and not by an intrinsic developmental program of the ganglion cell body. The explant coculture system is an excellent model for analysis of the molecular basis of neuron-target interactions.Nocturnal rodents acquire much information about their environment through a chain of neuronal assemblies that bridges the whiskers and the cerebral cortex (1). Neocortical cells receiving this information are organized into modules or "barrels" whose distribution reflects the spatial organization of the whiskers; equivalent patterns of neuronal projection are found in the trigeminal regions ofbrainstem and thalamus (1). Neurons of the trigeminal ganglion constitute the first level of this pathway. They have peripheral and central processes that project to the whisker pad and brainstem, respectively. Brainstem afferent terminations are clustered in relation to a corresponding arrangement of postsynaptic neurons ("barrelettes"), which reflects the arrangement of whiskers on the snout (1). Because of the point-to-point representation of the vibrissae along the trigeminal neuraxis, this system has provided a model for investigations of axontarget interactions in the formation of sensory maps in the brain (1).During development, axons exhibit two distinct growth modes. Initially they elongate, without branching, toward their target and form a tract (2-8). Next, parent axons in the tract emit collaterals, which penetrate target zones and form arbors therein; as development proceeds, some collaterals are eliminated, whereas others are elaborated. These two major modes of axon growth, elongation and collateral/arborThe publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "...

show abstract

Two distinct phases and mechanisms of axonal growth shown by primary vestibular fibres in the brain, demonstrated by parvalbumin immunohistochemistry

Cited by 85 publications

References 59 publications

Evidence of early topographic organization in the embryonic olivocerebellar projection: A model system for the study of pattern formation processes in the central nervous system

Evidence of early topographic organization in the embryonic olivocerebellar projection: A model system for the study of pattern formation processes in the central nervous system

Parvalbumin immunoreactivity in the reticular thalamic nucleus of developing rats.

Target-derived influences on axon growth modes in cultures of trigeminal neurons.

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