Two Distinct Amnesic Profiles in Behavioral Variant Frontotemporal Dementia

Bertoux, Maxime; Souza, Leonardo Cruz de; Corlier, Fabian; Lamari, Foudil; Bottlaender, Michel; Dubois, Bruno; Sarazin, Marie

doi:10.1016/j.biopsych.2013.08.017

Cited by 83 publications

(75 citation statements)

References 31 publications

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“…In more details, the preservation of episodic memory in bvFTD has been recently challenged by an increasing number of independent studies showing that bvFTD patients can present with similar levels of amnesia as Alzheimer's disease, [4,5] with both manifesting a combination of frontally mediated and storagebased memory impairment. Although previous studies have suggested that prefrontal cortex degeneration might be the greatest determinant of amnesia in bvFTD, [21,22] more recent evidence suggest that bvFTD patients also show severe atrophy of the medial temporal lobes, including the hippocampus as well as the entire Papez circuit.…”

Section: Discussionmentioning

confidence: 99%

“…words-list based) may lack of power to differentiate the amnestic form of bvFTD from Alzheimer's disease. [3,5] By contrast, during the last decade, there has been increasing evidence for the ability of social cognition assessment to distinguish bvFTD from other diseases and specifically from Alzheimer's disease, [23] as it taps into ventral and rostral parts of the medial prefrontal cortex, [24,25] which are specifically damaged in bvFTD, [26] even at the early stages of the disease. [27] However, the utility of social cognition tasks to differentiate amnestic bvFTD from Alzheimer's disease has not been investigated before.…”

Section: Discussionmentioning

confidence: 99%

“…[1,2] However, increasing evidence suggest that bvFTD patients can show episodic memory deficits, [3] with a subgroup of bvFTD patients being impaired to a similar level as Alzheimer's disease, even in biologically and pathologically confirmed cases. [4,5] Similarly, on a neural level, memory-related structures of the limbic system are found to be affected up to a similar degree as Alzheimer's disease in bvFTD. [3,[6][7][8] By contrast, social cognition assessments have emerged as powerful new tools to distinguish both diseases in a clinical setting, when CSF biomarkers or amyloid imaging are not available.…”

Section: Introductionmentioning

confidence: 96%

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Social Cognition Deficits: The Key to Discriminate Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease Regardless of Amnesia?

Bertoux

Souza

O’Callaghan

et al. 2016

JAD

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Relative sparing of episodic memory is a diagnostic criterion of behavioural variant frontotemporal dementia (bvFTD). However, increasing evidences suggest that bvFTD patients can show episodic memory deficits at a similar level as Alzheimer's disease (AD). Social cognition tasks have been proposed to distinguish bvFTD, but no study to date has explored the utility of such tasks for the diagnosis of amnestic bvFTD. Here, we contrasted social cognition performance of amnestic and nonamnestic bvFTD from AD, with a subgroup having confirmed in vivo pathology markers.Ninety-six participants (38 bvFTD and 28 AD patients as well as 30 controls) performed the short Social-cognition and Emotional Assessment (mini-SEA). BvFTD patients were divided into amnestic versus non-amnestic presentation using the validated Free and Cued Selective Reminding Test (FCSRT) assessing episodic memory.As expected, the accuracy of the FCSRT to distinguish the overall bvFTD group from AD was low (69.7%) with ~50% of bvFTD patients being amnestic. By contrast, the diagnostic accuracy of the mini-SEA was high (87.9%). When bvFTD patients were split on the level of amnesia, mini-SEA diagnostic accuracy remained high (85.1%) for amnestic bvFTD vs. AD and increased to very high (93.9%) for non-amnestic bvFTD vs. AD.Social cognition deficits can distinguish bvFTD and AD regardless of amnesia to a high degree and provide a simple way to distinguish both diseases at presentation. These findings have clear implications for the diagnostic criteria of bvFTD. They suggest that the emphasis should be on social cognition deficits with episodic memory deficits not being a helpful diagnostic criterion in bvFTD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Social Cognition Deficits: The Key to Discriminate Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease Regardless of Amnesia?

Bertoux

Souza

O’Callaghan

et al. 2016

JAD

Self Cite

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show abstract

“…Si bien, frecuentemente, se habla que la DFT-vc no cursa con déficit de memoria episódica 5 , durante los últimos años este paradigma ha cambiado, demostrando que la DFT-vc puede presentar alteraciones en la memoria episódica [7][8][9][10][11][12] . Es conocida la relación existente entre las funciones ejecutivas y los circuitos de memoria, además, del rol que cumple la corteza prefrontal en estas funciones.…”

Section: Discussionunclassified

“…Se ha establecido que la DFT-vc no cursaría con déficit de memoria, encontrándose la memoria episódica relativamente conservada; de hecho la afectación de la memoria constituiría un criterio de exclusión para DFT-vc 5 . Pese a lo anterior, diversos estudios en la última década [9][10][11][12] , han demostrado que pacientes con DFT-vc podrían manifestar severos déficits en la memoria episódica, similares a los pesquisados en la Enfermedad de Alzheimer (EA).…”

Section: Introductionunclassified

Quejas de memoria en demencia frontotemporal variante conductual: a propósito de un caso

Pavez

2018

Rev. chil. neuro-psiquiatr.

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Progression in Behavioral Variant Frontotemporal Dementia

et al. 2015

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IMPORTANCE A gap in the literature exists regarding progression in behavioral variant frontotemporal dementia (BVFTD). Guidance is needed concerning markers that will enable clinicians to discriminate FTD more effectively from phenocopies and to identify factors that determine progression and thereby prognosis. OBJECTIVES To observe longitudinal outcomes and progression in probable and possible BVFTD in accordance with international diagnostic criteria and to identify features that may aid clinicians to prognosticate better in cases of possible BVFTD. DESIGN, SETTING, AND PARTICIPANTS Longitudinal cohort study performed in a specialist tertiary FTD research clinic. Fifty-eight consecutive patients were followed up longitudinally from January 1, 2008, through December 31, 2013, and classified as having possible, probable, or definite BVFTD at presentation and latest review. Final follow-up was completed on December 31, 2013, and data were analyzed from January 1 to August 1, 2014. MAIN OUTCOMES AND MEASURES Clinical, pathological, genetic, neuropsychological, and neuroimaging data were analyzed to categorize patients, to compare differences between groups with changed and unchanged diagnoses, to determine rates of progression in BVFTD, and to identify prognostic features in possible BVFTD. RESULTS At presentation, 38 of the 58 patients fulfilled criteria for probable BVFTD; of these, 36 continued to satisfy probable criteria or underwent conversion to definite criteria over time. The remaining 20 patients satisfied possible criteria only, and 11 of these patients changed categories over time to probable or definite BVFTD and showed progression on cognitive and functional measures (termed changed status). Of these 11 patients, 8 (73%) carried the C9orf72 expansion. A positive family history, memory impairment, and clinical abnormalities at presentation were key features of progression (P < .05). A continuum of neuropsychological scores, progression rates, and atrophy severity emerged across patients in probable, possible, changed status, and nonchanged status groups; patients with probable BVFTD exhibited the most severe abnormalities. CONCLUSIONS AND RELEVANCE Behavioral variant FTD shows variable progression over time. Clinicians can use a detailed neurologic and cognitive assessment to identify key predictive features of progression when faced with possible BVFTD, whereas a diagnosis of probable BVFTD is accurate in a clinical setting.

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Two Distinct Amnesic Profiles in Behavioral Variant Frontotemporal Dementia

Cited by 83 publications

References 31 publications

Social Cognition Deficits: The Key to Discriminate Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease Regardless of Amnesia?

Social Cognition Deficits: The Key to Discriminate Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease Regardless of Amnesia?

Quejas de memoria en demencia frontotemporal variante conductual: a propósito de un caso

Progression in Behavioral Variant Frontotemporal Dementia

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