Abstract:A variety of two-dimensional (2D) nanomaterials, including graphene oxide and clays, are known to stabilize Pickering emulsions to fabricate structures for functions in sensors, catalysts, and encapsulation. We introduce here a novel Pickering emulsion using self-assembled amphiphilic triblock oligoglycine as the emulsifier. Peptide amphiphiles are more responsive to environmental changes (e.g., pH, temperature, and ionic strength) than inorganic 2D materials, which have a chemically rigid, in-plane structure.… Show more
“…65 Pickering emulsions stabilised by 2T alone are poorly stable at neutral pH. 42 Hence, they are considered unsuitable candidates for ocular drug delivery and were not studied here.…”
Section: Evaluation For Ocular Drug Delivery Applicationsmentioning
confidence: 99%
“…40,41 We have previously used self-assembled sheets of 2T to emulsify oil in water at a neutral pH. 42 We now hypothesise that the charged terminal amino groups on 2T will enhance mucoadhesion on ocular tissue. However, emulsions stabilised by 2T alone do not have adequate stability at a neutral pH for ocular drug delivery.…”
Oil-in-water emulsions, stabilised with conventional surfactants, are commonly used in eye drops for ocular drug delivery. However, the presence of surfactants can sometimes irritate tissues. Furthermore, conventional emulsions often have...
“…65 Pickering emulsions stabilised by 2T alone are poorly stable at neutral pH. 42 Hence, they are considered unsuitable candidates for ocular drug delivery and were not studied here.…”
Section: Evaluation For Ocular Drug Delivery Applicationsmentioning
confidence: 99%
“…40,41 We have previously used self-assembled sheets of 2T to emulsify oil in water at a neutral pH. 42 We now hypothesise that the charged terminal amino groups on 2T will enhance mucoadhesion on ocular tissue. However, emulsions stabilised by 2T alone do not have adequate stability at a neutral pH for ocular drug delivery.…”
Oil-in-water emulsions, stabilised with conventional surfactants, are commonly used in eye drops for ocular drug delivery. However, the presence of surfactants can sometimes irritate tissues. Furthermore, conventional emulsions often have...
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