Two-dimensional superlattice films of gold nanoparticle-polystyrene composites: a bioactive platform for bone homeostasis maintenance

Abstract

Osseo-integration between the implant and bone is a crucial factor to create a strong, durable bond that allows the implant to function effectively. However, regular implant surface with poor osseo-integration ability may cause aseptic loosening, resulting in the failure of implants. Herein, a serial of macroscopic one-particle thick superlattice films generated by self-assembly of diverse size of gold nanoparticles (GNPs) were termed as SFGs and were considered as bioactive implant coatings for enhancing osseo-integration. A hydroquinone-assisted seed method is established to fabricate homogenous GNPs with controllable sizes (20, 60, and 90 nm), which were further employed as building blocks to generate macroscopic one-particle thick superlattice films of GNPs (SFGs-20, SFGs-60, and SFGs-90) with the assistance of ploystryrene. The SFGs present a size-dependent performance on bone homeostasis, where SFGs-90 demonstrated the most pronounced facilitation of osteogenic differentiation of osteoblasts as well as deactivation of osteoclasts compared with SFGs-20 and SFGs-60. Considering the universal applicability of SFGs for depositing on various substrates, these SFGs with enhanced osseo-integration capabilities could serve as a bioactive platform for surface modification of orthopedic implants, effectively addressing the issue of aseptic loosening. Graphical abstract Two-dimensional superlattice films of gold nanoparticle-polystyrene composites exhibit enhanced osteogenic-stimulation and osteoclastic-inhibition effects for regulating bone homeostasis maintenance.

Flexible nanohybrid substrates utilizing gold nanocubes/nano mica platelets with 3D lightning-rod effect for highly efficient bacterial biosensors based on surface-enhanced Raman scattering

“…AuNCs were synthesized using an improved seed-mediated method. 43 First, the gold seed solution was prepared. HAuCl 4 (0.01 M, 0.25 mL) and CTAC (0.1 M, 9.75 mL) were thoroughly mixed, and NaBH 4 (0.02 M, 0.45 mL) was added slowly in an ice bath and stirred vigorously for 1–2 s. At this time, the solution turned brown.…”

Remarkable Toughening of Plastic with Monodispersed Nano-CaCO3: From Theoretical Predictions to Experimental Validation

“…However, the hydrophilic surface and large surface energy of inorganic nanoparticles will lead to poor compatibility with polymer matrices − and agglomerations, − leading to a decrease in mechanical properties. According to the structure of polymer matrices, selecting suitable dispersants or coupling agents to modify the surface of nanoparticles is essential to prevent the aggregation of these nanoscale inorganic particles and improve the performances of nanocomposites. − Moreover, the preparation process of nanocomposites is also very important. − In situ polymerization is one of the effective ways to overcome these problems and prepare nanocomposites with excellent properties. ,, …”