Two-dimensional population balance modelling and validation of combined cooling and antisolvent crystallization of <scp>l</scp>-asparagine monohydrate

Lenka, Maheswata; Bhoi, Stutee; Sarkar, Debasis

doi:10.1039/d2ce01566h

Cited by 2 publications

(1 citation statement)

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“…As mentioned earlier, when the solubility of a compound is highly dependent on both temperature change and the addition of a proper antisolvent, the combination of cooling and antisolvent crystallization (CCAC) can significantly improve process performance through higher crystallization yield, improved product CSD, polymorph control, reduced batch time, and lower energy costs [54]. Additional benefits can be achieved using a hybrid crystallization technique that integrates CCAC.…”

Section: Coupled Antisolvent Crystallization Of Pharmaceuticalsmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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Continuous crystallization of pharmaceuticals has been in the center of attention during the past two decades, with a more focus on the large‐scale production of active pharmaceutical ingredients. The increasing demand for pharmaceuticals requires high‐throughput production of drug crystals with different solubilities, stabilities, shapes, habits, polymorphs, and size distributions. With numerous advantages including low cost, ease of scale‐up, and superior control over polymorph and size distribution of drug crystals, antisolvent crystallization is one of the most promising crystallization methods recently attempted. However, it fails to deliver the required characteristic where the crystal systems tend to grow and for the preparation of metastable polymorphs. This review focuses on the most recent efforts to tackle these drawbacks by coupling antisolvent crystallization with cooling, supercritical‐assisted, microfluidics‐assisted, and membrane‐assisted crystallization. This systematic review aims to provide a concise summary of each coupled antisolvent technique and their positive and negative aspects. This review can be used as a guideline for pharmacist, biologists, and chemists, who are interested in the crystal engineering of pharmaceuticals to pave the way for further developments in this field.

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Section: Coupled Antisolvent Crystallization Of Pharmaceuticalsmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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Euler’s First-Order Explicit Method–Peridynamic Differential Operator for Solving Two-Dimensional Population Balance Equations in Crystallization

Dong,

Ruan

2024

Crystals

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The population balance equations (PBEs) serve as the primary governing equations for simulating the crystallization process. Two-dimensional (2D) PBEs pertain to crystals that exhibit anisotropic growth, which is characterized by changes in two internal coordinates. Because PBEs are the hyperbolic equations, it becomes imperative to establish a high-resolution scheme to reduce numerical diffusion and numerical dispersion, thereby ensuring accurate crystal size distribution. This paper uses Euler’s first-order explicit (EE) method–Peridynamic Differential Operator (PDDO) to solve 2D PBE, namely, the EE method for discretizing the time derivative and the PDDO for discretizing the internal crystal-size derivative. Five examples, including size-independent growth with smooth and non-smooth distributions, size-dependent growth, nucleation, and size-independent/dependent growth for batch crystallization are considered. The results show that the EE–PDDO method is more accurate than the HR method and that it is as good as the fifth-order Weighted Essential Non-Oscillatory (WENO) method in solving 2D PBE. This study extends the EE–PDDO method to the simulation of 2D PBE, and the advantages of the EE-PDDO method in dealing with discontinuous and sharp front problems are demonstrated.

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Two-dimensional population balance modelling and validation of combined cooling and antisolvent crystallization of l-asparagine monohydrate

Abstract: Combining cooling and antisolvent modes of crystallization is advantageous as it may significantly improve the process performance. A set of experiments were conducted on combined cooling and antisolvent crystallization of...

Cited by 2 publications

References 37 publications

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Euler’s First-Order Explicit Method–Peridynamic Differential Operator for Solving Two-Dimensional Population Balance Equations in Crystallization

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