Two-dimensional myocardial deformation in coronary vasospasm-related Takotsubo cardiomyopathy

Hung, Ming‐Jui; Ko, Ta; Liang, Chung-Yu; Kao, Yu-Cheng

doi:10.1097/md.0000000000008232

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…One of the most established and unifying hypothesis pertains to sympathetic nervous system derangement and subsequent catecholaminergic imbalances 6, 7. The possible overlap between TTS and coronary vasospasm has been highlighted in the contemporary literature, although the specific nature of a possible relationship still warrants further ascertainment 1, 2, 8, 9, 10. As described in this case report, and in accordance with the current guidelines, the presence of both these entities can have therapeutic importance 1, 11.…”

supporting

confidence: 65%

Takotsubo syndrome and coronary vasospasm: Two faces of the same coin?

Vilela

Silva

Guerreiro

et al. 2018

Indian Heart Journal

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supporting

confidence: 65%

Takotsubo syndrome and coronary vasospasm: Two faces of the same coin?

Vilela

Silva

Guerreiro

et al. 2018

Indian Heart Journal

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“…In 2017, Hung et al . [ 166 ], performing an echocardiographic study in a patient with TS, found indirect signs of global coronary artery vasospasm in the form of a decrease in the deformation characteristics of the left heart chambers.…”

Section: Pathogenesis Of Stress Cardiomyopathymentioning

confidence: 99%

Takotsubo Syndrome: Clinical Manifestations, Etiology and Pathogenesis

Прокудина

Kurbatov

Zavadovsky

et al. 2021

CCR

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: The purpose of the review is the analysis of clinical and experimental data on the etiology and pathogenesis of takotsubo syndrome (TS). TS is characterized by contractile dysfunction, which usually affects the apical region of the heart, lack of coronary artery obstruction, moderate increase in myocardial necrosis markers, prolonged QTc interval (in 50% of patients), sometimes elevation of ST segment (in 19% of patients), increase N-Terminal Pro-B-Type Natriuretic Peptide level, microvascular dysfunction, sometimes spasm of the epicardial coronary arteries (in 10% of patients), myocardial edema, and life-threatening ventricular arrhythmias (in 11% of patients). Stress cardiomyopathy is a rare disease, it is observed in 0.6 - 2.5% of patients with acute coronary syndrome. The occurrence of takotsubo syndrome is 9 times higher in women, who are aged 60-70 years old , than in men. The hospital mortality among patients with TS corresponds to 3.5% - 12%. In many patients with TS, but not in all, physical or emotional stress precedes the disease. Many patients with TS, but not all, have neurological or mental illnesses. The level of catecholamines is increased in patients with TS, therefore, the occurrence of TS is associated with the excessive activation of the adrenergic system. The negative inotropic effect of catecholamines is associated with the activation of β2 adrenergic receptors. An important role of the adrenergic system in the pathogenesis of TS is confirmed by studies which were performed using 125I-metaiodobenzylguanidine (125I –MIBG). TS causes edema and inflammation of the myocardium. The inflammatory response in TS is systemic. TS causes impaired coronary microcirculation and reduces coronary reserve. There is reason to believe that an increase in blood viscosity may play an important role in the pathogenesis of microcirculatory dysfunction in patients with TS. Epicardial coronary artery spasm is not obligatory for the occurrence of TS. Cortisol, endothelin-1 and microRNAs are challengers for the role of TS triggers. A decrease in estrogen levels is a factor contributing to the onset of TS. The central nervous system appears to play an important role in the pathogenesis of TS.

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Two-dimensional myocardial deformation in coronary vasospasm-related Takotsubo cardiomyopathy

Cited by 2 publications

References 46 publications

Takotsubo syndrome and coronary vasospasm: Two faces of the same coin?

Takotsubo syndrome and coronary vasospasm: Two faces of the same coin?

Takotsubo Syndrome: Clinical Manifestations, Etiology and Pathogenesis

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