Two-dimensional MXene/nano-hydroxyapatite nanocomposite promotes osteogenesis by photothermal conversion

Zhang, Jiebing; Tang, Shuang; Ding, Ning; Ma, Pibo; Zhang, Zutai

doi:10.1016/j.ceramint.2023.06.172

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…These characteristics make them particularly suitable for our engineering and biological objectives. Recently, MXene has been reported to have osteoconductive properties. ,, We also selected HAP, the principal inorganic component of human hard tissues such as cortical bone and teeth to which it has a high bonding affinity . In the LbL assembly, it serves as a complementary species of MXene, imparting osteoconductive properties (i.e., capability to specifically support the attachment and proliferation of osteoprogenitor cells) to the coatings .…”

Section: Resultsmentioning

confidence: 99%

“…A key aspect of our approach was the deposition of a 2D nanomaterial (MXene) and an inorganic nanoparticle (hydroxyapatite, HAP). MXene, a group of transition metal carbides/nitrides/carbonitrides, has been recognized for its high biocompatibility and osteoconductive properties, presenting promising potential in biomedical applications. , HAP (Ca 5 (PO 4 ) 3 (OH)), a key component of human hard tissue, is renowned for its high osteoconductivity, making it an ideal material candidate for orthopedic uses . The atomically thin properties of MXene allowed for the creation of ultrathin films using the layer-by-layer (LbL) fabrication method.…”

Section: Introductionmentioning

confidence: 99%

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Designer Micro-/Nanocrumpled MXene Multilayer Coatings Accelerate Osteogenesis and Regulate Macrophage Polarization

Asadi Tokmedash,

Min

2024

ACS Appl. Mater. Interfaces

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Effective tissue regeneration and immune responses are essential for the success of biomaterial implantation. Although the interaction between synthetic materials and biological systems is well-recognized, the role of surface topographical cues in regulating the local osteoimmune microenvironmentspecifically, their impact on host tissue and immune cells, and their dynamic interactionsremains underexplored. This study addresses this gap by investigating the impact of surface topography on osteogenesis and immunomodulation. We fabricated MXene/hydroxyapatite (HAP)-coated surfaces with controlled 2.5D nano-, submicro-, and microscale topographical patterns using our custom bottom-up patterning method. These engineered surfaces were employed to assess the behavior of osteoblast precursor cells and macrophage polarization. Our results demonstrate that MXene/HAP-coated surfaces with microscale crumpled topography significantly influence osteogenic activity and macrophage polarization: these surfaces notably enhanced osteoblast precursor cell spreading, proliferation, and differentiation and facilitated a shift in macrophages toward an anti-inflammatory, prohealing M2 phenotype. The observed cell responses indicate that the physical cues from the crumpled topographies, combined with the chemical cues from the MXene/HAP coatings, synergistically create a favorable osteoimmune microenvironment. This study presents the first evidence of employing MXene/HAP-multilayer coated surfaces with finely crumpled topography to concurrently facilitate osteogenesis and immunomodulation for improved implant-to-tissue integration. The tunable topographic patterns of these coatings coupled with a facile and scalable fabrication process make them widely applicable for various biomedical purposes. Our results highlight the potential of these multilayer coatings with controlled topography to improve the in vivo performance and fate of implants by modulating the host response at the material interface.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Designer Micro-/Nanocrumpled MXene Multilayer Coatings Accelerate Osteogenesis and Regulate Macrophage Polarization

Asadi Tokmedash,

Min

2024

ACS Appl. Mater. Interfaces

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“…Recently, MXene has been reported to have osteoconductive properties. 18, 19, 25 We also selected Hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 )-the principal inorganic component of human hard tissues such as cortical bone and teeth to which it has a high bonding affinity. 26 In the LbL assembly, it serves as a complementary species of MXene, imparting osteoconductive properties (i.e., capability to specifically support the attachment and proliferation of osteoprogenitor cells) to the coatings.…”

Section: Resultsmentioning

confidence: 99%

“…MXene, a group of transition metal carbides/nitrides/carbonitrides, has been recognized for its high biocompatibility and osteoconductive properties, presenting promising potential in biomedical applications. 18, 19 HAP (Ca 5 (PO 4 ) 3 (OH)), a key component of human hard tissue, is renowned for its high osteoconductivity, making it an ideal material candidate for orthopedic uses. 20 The atomically thin properties of MXene allowed for the creation of ultra-thin films using the layer-by-layer (LbL) fabrication method.…”

Section: Introductionmentioning

confidence: 99%

Designer micro/nano-crumpled MXene multilayer coatings accelerate osteogenesis and regulate macrophage polarization

Tokmedash,

Min

2024

Preprint

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Effective tissue regeneration and immune responses are essential for the success of biomaterial implantation. Although the interaction between synthetic materials and biological systems is well-recognized, the role of surface topographical cues in regulating the local osteoimmune microenvironment—specifically, their impact on host tissue and immune cells and their dynamic interactions—remains underexplored. This study addresses this gap by investigating the impact of surface topography on osteogenesis and immunomodulation. We fabricated MXene/Hydroxyapatite (HAP)-coated surfaces with controlled 2.5D nano-, submicro-, and micro-scale topographical patterns using our custom bottom-up pattering method. These engineered surfaces were employed to assess the behavior of osteoblast precursor cells and macrophage polarization. Our results demonstrate that MXene/HAP-coated surfaces with microscale crumpled topography significantly influence osteogenic activity and macrophage polarization: These surfaces notably enhanced osteoblast precursor cell spreading, proliferation, differentiation, and facilitated a shift in macrophages towards an anti-inflammatory, pro-healing M2 phenotype. The observed cell responses indicate that the physical cues from the crumpled topographies, combined with the chemical cues from the MXene/HAP coatings, synergistically create a favorable osteoimmune microenvironment. This study presents the first evidence of employing MXene/HAP-multilayer coated surfaces with finely crumpled topography to concurrently facilitate osteogenesis and immunomodulation for improved implant-to-tissue integration. The tunable topographic patterns of these coatings, coupled with a facile and scalable fabrication process, make them widely applicable for various biomedical purposes. Our results highlight the potential of these novel coatings to improve thein vivoperformance and fate of implants by modulating the host response at the material interface.

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Photothermal modulation of gingival fibroblasts via polydopamine-coated zirconia: A novel approach for promoting peri-implant soft tissue integration

Wang,

Zhang,

et al. 2024

Journal of Stomatology, Oral and Maxillofacial Surgery

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Two-dimensional MXene/nano-hydroxyapatite nanocomposite promotes osteogenesis by photothermal conversion

Cited by 3 publications

References 36 publications

Designer Micro-/Nanocrumpled MXene Multilayer Coatings Accelerate Osteogenesis and Regulate Macrophage Polarization

Designer Micro-/Nanocrumpled MXene Multilayer Coatings Accelerate Osteogenesis and Regulate Macrophage Polarization

Designer micro/nano-crumpled MXene multilayer coatings accelerate osteogenesis and regulate macrophage polarization

Photothermal modulation of gingival fibroblasts via polydopamine-coated zirconia: A novel approach for promoting peri-implant soft tissue integration

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