Two-dimensional materials in biomedical, biosensing and sensing applications

Rohaizad, Nasuha; Mayorga‐Martinez, Carmen C.; Fojtů, Michaela; Latiff, Naziah Mohamad; Pumera, Martin

doi:10.1039/d0cs00150c

Cited by 274 publications

(179 citation statements)

References 322 publications

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“…However, it may be degraded at the presence of activated, degranulating neutrophils, by erythrophagocytosis in liver Kupffer cells, or by photodegradation in normal (HEK-293) and cancerous (HeLa and HepG2) human cells 34 – 46 . Graphene may cause different levels of tissue damage in organs (such as the lung) 37 . In the nervous system, previous researches showed widely divergent outcomes in various settings.…”

Section: Discussionmentioning

confidence: 99%

Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

et al. 2021

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As the application of graphene nanomaterials gets increasingly attractive in the field of tissue engineering and regenerative medicine, the long-term evaluation is necessary and urgent as to their biocompatibility and regenerative capacity in different tissue injuries, such as nerve, bone, and heart. However, it still remains controversial about the potential biological effects of graphene on neuronal activity, especially after severe nerve injuries. In this study, we establish a lengthy peripheral nerve defect rat model and investigate the potential toxicity of layered graphene-loaded polycaprolactone scaffold after implantation during 18 months in vivo. In addition, we further identify possible biologically regenerative effects of this scaffold on myelination, axonal outgrowth, and locomotor function recovery. It is confirmed that graphene-based nanomaterials exert negligible toxicity and repair large nerve defects by dual regulation of Schwann cells and astroglia in the central and peripheral nervous systems. The findings enlighten the future of graphene nanomaterial as a key type of biomaterials for clinical translation in neuronal regeneration.

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Section: Discussionmentioning

confidence: 99%

Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

et al. 2021

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“…Inspired by the above works, kinds of other 2D nanoprobes have been constructed for biosensing. [160][161][162]…”

Section: Dna Nanostructures For Biosensingmentioning

confidence: 99%

Rationally Programming Nanomaterials with DNA for Biomedical Applications

Gang

et al. 2021

Advanced Science

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DNA is not only a carrier of genetic information, but also a versatile structural tool for the engineering and self-assembling of nanostructures. In this regard, the DNA template has dramatically enhanced the scalability, programmability, and functionality of the self-assembled DNA nanostructures. These capabilities provide opportunities for a wide range of biomedical applications in biosensing, bioimaging, drug delivery, and disease therapy. In this review, the importance and advantages of DNA for programming and fabricating of DNA nanostructures are first highlighted. The recent progress in design and construction of DNA nanostructures are then summarized, including DNA conjugated nanoparticle systems, DNA-based clusters and extended organizations, and DNA origami-templated assemblies. An overview on biomedical applications of the self-assembled DNA nanostructures is provided. Finally, the conclusion and perspectives on the self-assembled DNA nanostructures are presented.

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“…The great potential of 2D materials, in the development of new hybrid platforms for biomedical applications, is well known. [50][51][52][53][54][55][56] However, the elimination of nanomaterials such as NBP and GO from the body is mandatory for their possible safe and clinical use. This is the reason why the biodegradability of GO has been widely investigated in the last years.…”

Section: Biodegradation By-designmentioning

confidence: 99%

Does black phosphorus hold potential to overcome graphene oxide? A comparative review of their promising application for cancer therapy

Ruiz

Martín

Reina³

2021

Nanoscale Adv.

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Two-dimensional materials in biomedical, biosensing and sensing applications

Abstract: 2D materials are at the forefront of materials research, advancing in applications for biomedical and bio/sensing. We elucidate properties of 2D materials beyond graphene that are relevant to those applications, as well as their correlation with toxicity.

Cited by 274 publications

References 322 publications

Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

Rationally Programming Nanomaterials with DNA for Biomedical Applications

Does black phosphorus hold potential to overcome graphene oxide? A comparative review of their promising application for cancer therapy

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