Two dimensional mapping of the perfusion of the retina and optic nerve head.

Michelson, Georg; Schmauß, Bernhard

doi:10.1136/bjo.79.12.1126

Cited by 157 publications

(114 citation statements)

References 7 publications

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“…By using non-invasive technologies such as Scanning Laser Doppler Flowmetry (SLDF) and analysis softwares that produce highly reproducible intrasession and intersession results such as the Automatic Full Field Perfusion Image Analyzer software (AFFPIA-SLDF 3.3, G Michelson, Erlangen, Germany), [12][13][14][15][16][17][18] it is possible to accurately assess the haemodynamic effects of antiglaucomatous drugs.…”

Section: Introductionmentioning

confidence: 99%

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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Purpose To compare the effect of dorzolamide hydrochloride 2%, timolol maleate 0.5%, and their fixed combination on intraocular pressure (IOP) and retinal and optic nerve head haemodynamics in primary open-angle glaucoma patients. Methods Twenty-eight patients with early-moderate glaucomatous damage treated with b-blockers (46 months) with IOP values ranging from 18 to 22 mmHg at trough participated in this trial. After a 4-week washout period, patients were randomized in two groups: group I started with dorzolamide 2% monotherapy and group II with timolol 0.50% monotherapy for 4 weeks. After this period, both groups switched to dorzolamide/ timolol fixed combination for 4 weeks. IOP, ocular diastolic perfusion pressure (ODPP), heart rate, and Scanning Laser Doppler Flowmetry measurements at the peripapillary retina and neuroretinal rim were taken at T0 (enrolment), T1 (wash out), T2 (monotherapy), and T3 (dorzolamide/timolol). Data were compared between different study times. Statistical analysis was conducted using a paired t-test. Results Between T1 and T3, IOP decreased significantly in group I (À21.40%) (Po0.001) and in group II (À21.25%) (Po0.001). At the same time intervals, blood flow increased significantly at rim level for group I ( þ 30.03%) (Po0.05) and also when all patients were considered (rim þ 17.99%) (Po0.05). Between T1 and T3, we also observed a significant increase of ODPP in group I ( þ 7.24%) (Po0.01) and in group II ( þ 6.08%) (Po0.05) and when all patients were considered ( þ 8.43%) (Po0.01). Conclusions Dorzolamide/timolol fixed combination increased blood flow significantly at the neuroretinal rim showing a combination of hypotensive and haemodynamic effects.

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Section: Introductionmentioning

confidence: 99%

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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“…The HRF principle has previously been described in detail. 36,37 To collect HRF data, the border between the cup and the rim and the disc margin were defined. For this purpose, a confocal laser retina tomograph (Heidelberg retina tomograph; HRT) was used to obtain an anatomical scan.…”

Section: Ocular Perfusion Measurementsmentioning

confidence: 99%

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Gherghel

Hosking

Cunliffe

et al. 2006

Eye

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Purpose To evaluate the effect of latanoprost 0.005% on the optic nerve head (ONH) and retinal circulation of newly diagnosed and previously untreated primary open-angle glaucoma (POAG) patients. Methods Twenty-two newly diagnosed and previously untreated POAG patients (mean age7SD: 68.38711.92 years) were included in this longitudinal open-label study. Patients were treated with latanoprost 0.005% once a day. Intraocular pressure (IOP), systemic blood pressure (BP), mean ocular perfusion pressure (MOPP), and ocular perfusion parameters 'volume', 'velocity', and 'flow' measured at the optic nerve head (ONH) and retina by means of Heidelberg Retina Flowmeter system were evaluated during a 6-month follow-up period. Results Treatment with latanoprost 0.005% resulted in a significant decrease in IOP (Po0.0001) and increase in MOPP (Po0.0001). After correcting for changes in MOPP, the blood velocity measured at the ONH level was significantly higher after 6 months of treatment than at baseline (P ¼ 0.0310). In addition, blood volume and flow measured at the peripapillary retina level improved after 3 and 6 months of treatment (P ¼ 0.0170; P ¼ 0.0260, and P ¼ 0.0170; P ¼ 0.0240 respectively).Conclusion Previously untreated POAG patients exhibit reduced IOP, increased MOPP and improved ocular perfusion at the ONH and retina levels when treated with Latanoprost 0.005%. These effects could be beneficial for glaucoma patients suffering from ocular vascular dysregulation.

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“…6,7 Laser doppler scanning of the retina has become an established technology for the investigation of microvascular blood flow in the retina. [8][9][10] Using this technology, Cuypers and colleagues 11 found an increased retinal microvascular blood flow in patients with different stages of DR. In this study, patients with pronounced stages of DR revealed lower RBF compared with those with milder stages of DR.…”

Section: Introductionmentioning

confidence: 99%

Pilot Study for the Evaluation of Morphological and Functional Changes in Retinal Blood Flow in Patients with Insulin Resistance and/or Type 2 Diabetes Mellitus

Forst

Weber

Mitry³

et al. 2012

J Diabetes Sci Technol

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Two dimensional mapping of the perfusion of the retina and optic nerve head.

Cited by 157 publications

References 7 publications

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Pilot Study for the Evaluation of Morphological and Functional Changes in Retinal Blood Flow in Patients with Insulin Resistance and/or Type 2 Diabetes Mellitus

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