Two dimensional finite element estimation of calcium ions in presence fo NCX and Buffers in Astrocytes

Abstract

Sodium calcium exchanger (NCX) plays effective role in signal transduction in most of the nerve cells like neuron and astrocytes. Sodium ion affects the cytosolic calcium concentration level in Astrocytes via various channels. This affects the movement of the nerve impulse from one cell to other cell. In this paper two dimensional model is developed in the form of diffusion equation to study the effect of NCX in presence and absence of buffer in Astrocytes. Finite element method is employed to solve the problem and simulated in Matlab to estimate the effect of various parameter like flux, diffusion coefficient, buffer concentration, etc.

Chaos of calcium diffusion in Parkinson s infectious disease model and treatment mechanism via Hilfer fractional derivative

“…Also, there have been several experimental attempts that were performed in the past to identify the role and physiological impact of sodium calcium exchangers on various cells [13,14,15,16]. Beside this a researches has explored the role of parameters of calcium toolkits on astrocytes [17,18,19,20,21,22], neuron [23,24,25,26,27,28,29,30], oocytes [31,32], myocytes [33,34,35], hepatocytes [36], and T lymphocytes cells [37,38]. Thus a very little amount of work has attempted to study parameters of calcium toolkits by using the fractional calculus approach.…”