Two-dimensional (2D) materials beyond graphene in cancer drug delivery, photothermal and photodynamic therapy, recent advances and challenges ahead: A review

Molaei, Mohammad Jafar

doi:10.1016/j.jddst.2020.101830

Cited by 47 publications

(29 citation statements)

References 181 publications

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“…One was based on quantum dots and nanoparticles [131] (463 citations), and the other one was focused on self-lighting nanoparticles [132] (96 citations). Later, several reviews about nanotechnology were published [133][134][135][136][137][138][139][140][141][142][143][144][145], one of them also focused on photothermal therapy [146]. Apart from second-generation PS with improved selectivity and reduced toxicity, the third generation promises a total targeted therapy, in which PS can be selectively attached to specific tumour cells [147,148].…”

Section: Photosensitizersmentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

181

140

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Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources. The key issues and main conclusions are summarized, including ways and means to improve therapy and outcomes. Due to the broad scope of this work and it being the first time that a compendium of the latest reviews has been performed for PDT, it may be of interest to a wide audience.

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Section: Photosensitizersmentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

181

140

View full text Add to dashboard Cite

show abstract

“…For example, combining the photothermal properties of 2DnMat with thermo-/light responsive hydrogels can broaden the applications and goals of 2D nanomaterials in drug delivery and tissue engineering applications [ 22 , 28 ], by providing localized targeting [ 22 ].…”

Section: 2d Nanomaterials Polymeric Composites For Biomedical Applica...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The photothermal conversion ability, which allows the conversion of light into heat [ 22 ], is one of the properties of 2DnMat that makes them attractive for biomedical applications. On top of that, the bandgap of 2DnMat is layer dependent, meaning that it can be tuned to better adjust to the desired goal and application [ 22 , 23 , 24 ]. Therefore, the photothermal conversion ability of the 2DnMat can be enhanced by changing their physicochemical properties, for example, through functionalization/doping or varying their dimensions (number of layers and lateral size).…”

Section: Introductionmentioning

confidence: 99%

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New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

2022

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The constant evolution and advancement of the biomedical field requires robust and innovative research. Two-dimensional nanomaterials are an emerging class of materials that have risen the attention of the scientific community. Their unique properties, such as high surface-to-volume ratio, easy functionalization, photothermal conversion, among others, make them highly versatile for a plethora of applications ranging from energy storage, optoelectronics, to biomedical applications. Recent works have proven the efficiency of 2D nanomaterials for cancer photothermal therapy (PTT), drug delivery, tissue engineering, and biosensing. Combining these materials with hydrogels and scaffolds can enhance their biocompatibility and improve treatment for a variety of diseases/injuries. However, given that the use of two-dimensional nanomaterials-based polymeric composites for biomedical applications is a very recent subject, there is a lot of scattered information. Hence, this review gathers the most recent works employing these polymeric composites for biomedical applications, providing the reader with a general overview of their potential.

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“…Two-dimensional nanomaterials (2D-NM) are an intriguing class of materials exhibiting a sheet-like structure and peculiar physical and chemical properties, which arise when the thickness of bulk materials approaches the single layer ( Tan et al (2017) ; Fang et al (2020) ). Boosted by the success of graphene, 2D-NM have recently found applications in many fields ( Molaei (2021) ), including electronics, sensors, catalysis, and biomedicine ( Nguyen et al (2020) ). In this frame, transition metal dichalcogenides (TMDs) play a fundamental role ( Manzeli et al (2017) ).…”

Section: Introductionmentioning

confidence: 99%

Single-Cell Photothermal Analysis Induced by MoS2 Nanoparticles by Raman Spectroscopy

Rusciano

Capaccio

Sasso

et al. 2022

Front. Bioeng. Biotechnol.

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Two-dimensional nanomaterials, such as MoS2 nanosheets, have been attracting increasing attention in cancer diagnosis and treatment, thanks to their peculiar physical and chemical properties. Although the mechanisms which regulate the interaction between these nanomaterials and cells are not yet completely understood, many studies have proved their efficient use in the photothermal treatment of cancer, and the response to MoS2 nanosheets at the single-cell level is less investigated. Clearly, this information can help in shedding light on the subtle cellular mechanisms ruling the interaction of this 2D material with cells and, eventually, to its cytotoxicity. In this study, we use confocal micro-Raman spectroscopy to reconstruct the thermal map of single cells targeted with MoS2 under continuous laser irradiation. The experiment is performed by analyzing the water O-H stretching band around 3,400 cm−1 whose tetrahedral structure is sensitive to the molecular environment and temperature. Compared to fluorescence-based approaches, this Raman-based strategy for temperature measurement does not suffer fluorophore instability, which can be significant under continuous laser irradiation. We demonstrate that irradiation of human breast cancer MCF7 cells targeted with MoS2 nanosheets causes a relevant photothermal effect, which is particularly high in the presence of MoS2 nanosheet aggregates. Laser-induced heating is strongly localized near such particles which, in turn, tend to accumulate near the cytoplasmic membrane. Globally, our experimental outcomes are expected to be important for tuning the nanosheet fabrication process.

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Two-dimensional (2D) materials beyond graphene in cancer drug delivery, photothermal and photodynamic therapy, recent advances and challenges ahead: A review

Cited by 47 publications

References 181 publications

Photodynamic Therapy: A Compendium of Latest Reviews

Photodynamic Therapy: A Compendium of Latest Reviews

New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

Single-Cell Photothermal Analysis Induced by MoS2 Nanoparticles by Raman Spectroscopy

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