Two Different Roles of Purified CD45
 +
 c‐Kit
 +
 Sca‐1
 +
 Lin
 −
 Cells After Transplantation in Muscles

Yoshimoto, Momoko; Chang, Hsi; Shiota, Mitsutaka; Kobayashi, Hidekazu; Umeda, Katsutsugu; Kawakami, Koichi; Heike, Toshio; Nakahata, Tatsutoshi

doi:10.1634/stemcells.2004-0220

Cited by 13 publications

(12 citation statements)

References 36 publications

(48 reference statements)

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“…In this sense, the sustained expression of Pax7 in adult satellite cells may be due to sustained interactions with their niche, rather than a necessity for Pax7 function. In support of this hypothesis, genetically marked hematopoietic stem cells (bone marrow derived CD45 ϩ /c-Kit ϩ /Sca-1 ϩ /Lin Ϫ cells) have been shown to express Pax7 once they are present in the satellite cell niche (148,581).…”

Section: E Satellite Cells In Perinatal/juvenile Muscle Growthmentioning

confidence: 93%

“…ϩ are able to incorporate into newly forming myofibers (1,78,112,581), although it was unclear whether the progeny of these cells were able to occupy the satellite cell niche. It was also demonstrated that Mac-1 low bone marrow SP cells, particularly those c-Kit ϩ /CD11b Ϫ immature cells, were able to generate myofibers (147,382).…”

Section: Bone Marrow Stem Cellsmentioning

confidence: 99%

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Satellite Cells and the Muscle Stem Cell Niche

Yin

Price

Rudnicki

2013

Physiological Reviews

1,715

1,808

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LYin H, Price F, Rudnicki MA. Satellite Cells and the Muscle Stem Cell Niche. Physiol Rev 93: 23-67, 2013; doi:10.1152/physrev.00043.2011.-Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses. As skeletal muscle stem cells, satellite cells play an indispensible role in this process. The self-renewing proliferation of satellite cells not only maintains the stem cell population but also provides numerous myogenic cells, which proliferate, differentiate, fuse, and lead to new myofiber formation and reconstitution of a functional contractile apparatus. The complex behavior of satellite cells during skeletal muscle regeneration is tightly regulated through the dynamic interplay between intrinsic factors within satellite cells and extrinsic factors constituting the muscle stem cell niche/microenvironment. For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved our understanding of skeletal muscle biology. Here, we review some recent advances, with focuses on functions of satellite cells and their niche during the process of skeletal muscle regeneration.

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Section: E Satellite Cells In Perinatal/juvenile Muscle Growthmentioning

confidence: 93%

Section: Bone Marrow Stem Cellsmentioning

confidence: 99%

Satellite Cells and the Muscle Stem Cell Niche

Yin

Price

Rudnicki

2013

Physiological Reviews

1,715

1,808

View full text Add to dashboard Cite

show abstract

“…Transplantation of single hematopoietic stem cells (HSCs, CD45 þ /Sca1 þ or c-kit þ /Lin -/Sca1 þ cells), side-population cells, or BM-sorted CD45 þ and CD45 -cells, respectively, has revealed that only the hematopoietic subpopulation contains circulating cells with potential myogenic activity and that the progeny of a single HSC can contribute to muscle regeneration [4][5][6]. These findings, supported by numerous later studies [9,[11][12][13], demonstrated that BM-derived myogenesis, after BMT, results from the incorporation of hematopoietic cells into the muscle fiber and not from the differentiation of mesenchymal stem cells. Although the property of transplanted hematopoietic cells to incorporate into muscle fibers has been studied extensively, the ability of these cells to be reprogrammed is unclear, since some authors reported that donor nuclei fail to complete the myogenic program, when the expression of late muscle differentiation genes was analyzed [11,14].…”

Section: Introductionmentioning

confidence: 83%

Bone Marrow-Derived Hematopoietic Cells Undergo Myogenic Differentiation Following a Pax-7 Independent Pathway

et al. 2010

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Several reports showed that hematopoietic stem cells (HSCs) participate in muscle regeneration, raising hope for their therapeutic potential for degenerative muscle diseases. However, proof that HSCs are able to reprogram their fate and enter a myogenic pathway, remains elusive. We demonstrate that murine bone marrow (BM)-derived hematopoietic cells, carrying reporter genes controlled by muscle-specific regulatory elements from the Myf5, myosin light chain (MLC3F), or MCK genes, are induced by myoblasts to activate muscle-specific genes. This potential resides in the more undifferentiated progenitors, expressing surface markers typical of HSCs.Comparative gene expression profiling of CD45 1 /Sca1 1 cells isolated from muscle or BM shows that hematopoietic cells participate to muscle regeneration, by undergoing a profound although incomplete myogenic reprogramming on interaction with the muscle microenviroment. These cells undergo specification and differentiation independently from Pax7 and MyoD, and lack Pax7-associated properties, such as self-renewal and proliferation, distinguishing from satellite cells. Our findings indicate that hematopoietic cells, on seeding in the muscle, become a distinct cell population endowed with myogenic potential. STEM CELLS 2010;28:965-973 Disclosure of potential conflicts of interest is found at the end of this article.

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“…BMDCs are capable of engrafting the site of damage or inflammation to participate in the renewal and regeneration of different tissues and organs, such as the kidney [12], liver [13][14][15], muscle [16,17], heart [18], and gastrointestinal tract [7][8][9]. In the present study, in order to investigate the role of BMDCs in the process of gastric cancer formation, GFP expressing sex-mismatched bone marrow chimeric mice were subjected to carcinogen attack and successfully induced with gastric precancerous lesions and different histological types of mouse gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Evidence of cell fusion in carcinogen-induced mice gastric carcinoma

Yan

Hsu

et al. 2015

Tumor Biol.

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The role of bone marrow-derived cells in gastric cancer formation was not fully understood. In this study, bone marrow from female green fluorescent protein transgenic mice was transplanted into male wild-type mice to generate sex-mismatched chimeric mice. The chimeric mice were treated with carcinogen to induce gastric cancer. At time of sacrifice, 18.2 % (2/11) of mice showed severe dysplasia and 25 % (3/12) of mice successfully induced with cancer. Fluorescence in situ hybridization results showed that bone marrow-derived cells participated in renewal of gastric mucosa and cell fusion was observed in both precancerous lesions and adenocarcinoma, but no sign of fusion was observed in squamous cell carcinoma. Our findings suggest that bone marrow-derived cells participate in renewal of gastric mucosa during chronic damage and might have acquired the phenotype of gastric epithelial cells through cell fusion. Fusion between gastric epithelial cells and bone marrow-derived cells was involved in increased carcinogenesis.

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Two Different Roles of Purified CD45 ⁺ c‐Kit ⁺ Sca‐1 ⁺ Lin ⁻ Cells After Transplantation in Muscles

Cited by 13 publications

References 36 publications

Satellite Cells and the Muscle Stem Cell Niche

Satellite Cells and the Muscle Stem Cell Niche

Bone Marrow-Derived Hematopoietic Cells Undergo Myogenic Differentiation Following a Pax-7 Independent Pathway

Evidence of cell fusion in carcinogen-induced mice gastric carcinoma

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Two Different Roles of Purified CD45 + c‐Kit + Sca‐1 + Lin − Cells After Transplantation in Muscles

Cited by 13 publications

References 36 publications

Satellite Cells and the Muscle Stem Cell Niche

Satellite Cells and the Muscle Stem Cell Niche

Bone Marrow-Derived Hematopoietic Cells Undergo Myogenic Differentiation Following a Pax-7 Independent Pathway

Evidence of cell fusion in carcinogen-induced mice gastric carcinoma

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Two Different Roles of Purified CD45 ⁺ c‐Kit ⁺ Sca‐1 ⁺ Lin ⁻ Cells After Transplantation in Muscles