“…Numerous yeasts, including Saccharomyces cerevisiae, are highly sensitive to low concentrations (approximately 0.5 mg/ml) of this antibiotic. In contrast, other yeasts, including Schwanniomyces occidentalis (Debaromyces occidentalis; Barnett et al, 1983;del Pozo et al, 1993), Kluyveromyces lactis, K. fragilis (Adoutte-Panvier and Davies, 1984;Rao and Grollman, 1967), Candida maltosa, C. tropicalis (Takagi et al, 1985(Takagi et al, , 1986, Phaffia rhodozyma (Kim et al, 1998) and Cryptococcus neoformants (Varma and Kwon-Chung, 2000) are naturally resistant to cyh at rather high concentrations (i100 mg/ml). Resistance of cyh in yeast cells occurs by either modification of ribosomal proteins or expression of certain specific transport systems responsible for a multidrug resistance generally linked to the expression of MDR genes.…”