Two Dibenzylbutyrolactol Derivatives and Other Chemical Constituents from Aristolochia peltato-deltoidea

Abstract

Do extrato hexânico das partes aéreas de Aristolochia peltato-deltoidea Hoehne (Aristolochiaceae) foram isolados duas novas lignanas epiméricas do tipo dibenzilbutirolactol, rel-(8R, 8'S, 9S)-3,4-dimetoxi-3',4'-metilenodioxi-9β-etoxi-e rel-(8R, 8'S, 9R)-3,4-dimetoxi-3',4'-metilenodioxi-9α-etoxi-lignanas-8.8',9.O.9', além da neolignana benzofurânica eupomatenóide-7, α-tocoferilquinona, β-sitosterol e estigmasterol. Do extrato clorofórmico foram isoladas duas lignanas dibenzilbutirolactonas diasteroisoméricas:lenodioxi-9-oxo-lignanas-8.8',9.O.9'. A composição química das frações apolares do extrato hexânico também foi analisada por CG/EM. Dentre os componentes detectados, dez foram identificados. As estruturas dos compostos isolados foram elucidadas utilizando-se métodos espectrométricos.The hexane extract from the aerial parts of Aristolochia peltato-deltoidea Hoehne (Aristolochiaceae) afforded two new epimeric lignans dibenzylbutyrolactol type, rel-(8R, 8'S, 9S)-3,4-dimethoxy-3',4'-methylenodioxy-9β-ethoxy-and rel-(8R, 8'S, 9R)-3,4-dimethoxy-3',4'-methylenodioxy-9α-ethoxy-lignans-8.8',9.O.9', besides a benzofuran neolignan, known as eupomatenoid-7, α-tocopherylquinone, β-sitosterol and stigmasterol. From chloroform extract were isolated two diastereomeric dibenzylbutyrolactone lignans : rel-(8R, 8'R)-and rel-(8R, 8'S)-3,4-dimethoxy-3',4'-methylenodioxy-9-oxo-lignans-8.8',9.O.9'. Chemical composition analysis by GC/MS of the non polar fractions from hexane extract also was carried out and ten components were identified. The structures of the isolated compounds were elucidated utilizing spectrometric methods.