Two Decades of Experience with Ductal Carcinoma in Situ of the Breast in the Cancer Institute of Tehran, Iran

Omranipour, Ramesh; Alipour, Sadaf; Hadji, Maryam; Bagheri, Khojasteh

doi:10.7314/apjcp.2014.15.6.2771

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…For best outcomes for patients with breast cancer, steps should therefore be taken to modify factors associated with higher mastectomy rates (Roder et al, 2013). It is encouraging that active measures are being made in certain countries to increase BCT rates (Omranipour et al, 2014) despite the current trend of rising trend of mastectomy in others (McGuire et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Eligibility and Utilization of Breast Conservation Treatment in an Asian Context

Tan¹,

Sitoh²,

Sim³

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Evaluation of Eligibility and Utilization of Breast Conservation Treatment in an Asian Context

Tan¹,

Sitoh²,

Sim³

2014

Asian Pacific Journal of Cancer Prevention

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“…So far, studies on interventional breast biopsy for the detection of benign and malignant lesions have mainly involved CNB, and the findings are limited to VAB in patients with BC in Iran (12,13). Therefore, further investigations are needed to determine the efficacy of VAB in the management of patients with breast microcalcifications.…”

Section: Introductionmentioning

confidence: 99%

Successful Stereotactic-Guided Vacuum-Assisted Biopsy in the Evaluation of Breast Microcalcifications: A Study in a Single Tertiary Referral Center in the Middle East

et al. 2022

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Background: Breast microcalcifications are a category of lesions that can lead to malignancies. They remain a major concern in imaging of suspected cases. Vacuum-assisted biopsy (VAB) has been proposed as a safe and effective measure to evaluate microcalcifications. Objectives: The present study aimed to assess the results of VAB for breast microcalcifications. Patients and Methods: This cross-sectional study was conducted on patients with microcalcifications detected on mammograms. Patients were recruited through simple random sampling during 2019 - 2020, based on the inclusion criteria. The inclusion criteria were microcalcifications on mammography, classified as the breast imaging-reporting and data system (BI-RADS) categories 3, 4B, 4C, and 5, and undergoing mammography-guided VAB for the microcalcifications. Patients with missing data and those who could not be followed-up for at least six months were excluded from the study. They were assessed regarding different imaging characteristics of lesions, including the breast density, BI-RADS classification, microcalcification distribution and morphology, and other demographic and clinical features before biopsy. Additionally, the results of stereotactic-guided VAB were assessed for various benign and malignant pathologies of microcalcifications. The results of descriptive and analytical tests for various radiological and pathological features of lesions were reported. Results: A total of 257 patients, with a mean age of 50.3 ± 8.3 yars, were included in this study. Almost half of the patients (n = 125, 48.6%) had a C-grade breast composition. Regarding the BI-RADS classification, 206 (80.2%) patients were diagnosed with 4B lesions, followed by 44 (17.1%) patients with 4C lesions. The assessment of the pattern of microcalcification distribution in imaging showed that more than half of the patients (n = 148, 57.6%) had lesions in multiple groups. The most prevalent morphology of microcalcifications was punctate amorphous (n = 109, 42.4%). The majority of patients (n = 180, 70%) had benign findings in the pathological assessment, and only 69 (26.8%) had malignant features in pathology. The distribution of malignancies differed among various BI-RADS categories. In the 4B category of lesions, there were 166 benign lesions versus 32 malignant lesions, while in the 4C category, there were 10 benign lesions versus 34 malignant lesions (P < 0.001). Conclusion: This study described the findings of successful stereotactic-guided VAB for breast microcalcifications. VAB can be implemented as a promising assessment tool to evaluate suspected breast microcalcifications effectively.

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“…Breast cancer screening and higher quality mammography have resulted in an increase in the diagnosis of ductal carcinoma in situ worldwide [1] , it is characterized by a number of genetic aberrations. Although improvements have been achieved in recent years, few genetic biomarkers are available to easily identify individuals at risk for breast cancer or breast cancer progression [2] .…”

Section: Introductionmentioning

confidence: 99%

P53 mutation compared with Ki67 marker in metastasis of breast cancer in western Iran

Payandeh

Sadeghi

Fekri

et al. 2014

JST

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Objective: To investigate and compare the prognostic value of P53 and Ki67 markers with age and metastasis and survival in patients with breast cancer in Kermanshah, western Iran. Methods: In our study on 116 patients with breast cancer that all of them were women and kind of pathology was invasive ductal carcinoma and patients had Her2 positive. The expression of ki67 marker and p53 genes were determined by immunohistochemistry. Statistical analysis was performed with SPSS version IBM 19 and Disease free survival was calculated using the Kaplan-Meier method and log-rank test. Patients were followed up to 5 years. Results: The age mean of patients was 46.5±10.75.Of 116 patients, 23 patients (19.8%) had breast cancer with metastasis and 93(80.2%) without metastasis. expression of P53 (50%) in 58 patients was positive and 58(50%) was negative. there is a statistically significant relationship between the p53 and metastasis (P<0.05), but no for Ki67. The over expression of p53 protein and Ki67 had no significant relationship with survival rate (P>0.05). Conclusions: The results showed that the Ki67 marker and P53 protein are important factors in the breast cancer patients with emphasis on therapeutic agents.

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Two Decades of Experience with Ductal Carcinoma in Situ of the Breast in the Cancer Institute of Tehran, Iran

Cited by 6 publications

References 48 publications

Evaluation of Eligibility and Utilization of Breast Conservation Treatment in an Asian Context

Evaluation of Eligibility and Utilization of Breast Conservation Treatment in an Asian Context

Successful Stereotactic-Guided Vacuum-Assisted Biopsy in the Evaluation of Breast Microcalcifications: A Study in a Single Tertiary Referral Center in the Middle East

P53 mutation compared with Ki67 marker in metastasis of breast cancer in western Iran

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