Two‐day ‘weekend’ lansoprazole‐quadruple therapy for <i>Helicobacter pylori</i> infection

Boer, W. A. De; Etten, R. J. X. M. Van; Coremans,; Schneeberger,

doi:10.1046/j.1365-2036.1998.00266.x

Cited by 17 publications

(19 citation statements)

References 23 publications

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“…Among these studies, 7-day PPI plus standard bismuth triple therapy, which is now termed quadruple therapy , provides a consistently high eradication rate (approximately 96%) [10,16]. Several short-duration regimens for cure of H. pylori infection have been reported [2,3,[18][19][20][21][22][23][24]. Furthermore, this therapy has fewer adverse effects than commonly observed with 14-day bismuth triple therapy [17].…”

Section: Discussionmentioning

confidence: 99%

“…Generally, a simple regimen of short duration is convenient and preferable for patients and results in improved compliance. Several short-duration regimens for cure of H. pylori infection have been reported [2,3,[18][19][20][21][22][23][24]. With 4-day quadruple regimens consisting of PPI, bismuth, tetracycline, and metronidazole administered after 3 days of PPI pretreatment, cure rates were 86% to 94% [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

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Addition of Metronidazole to Rabeprazole‐Amoxicillin‐Clarithromycin Regimen for Helicobacter pylori Infection Provides an Excellent Cure Rate with Five‐Day Therapy

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Addition of Metronidazole to Rabeprazole‐Amoxicillin‐Clarithromycin Regimen for Helicobacter pylori Infection Provides an Excellent Cure Rate with Five‐Day Therapy

et al. 2000

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“…The eradication rate was similar if the same treatment was given for 4 days, but poor if the duration was further reduced to 2 days 14 , . 19 –23 We therefore designed a 3‐day quadruple therapy substituting tetracycline with clarithromycin, with no pre‐ or post‐treatment acid suppression. The short regimen was still able to achieve a high per protocol eradication rate of 94.3%.…”

Section: Discussionmentioning

confidence: 99%

Three‐day lansoprazole quadruple therapy for Helicobacter pylori‐positive duodenal ulcers: a randomized controlled study

Wong

Wang

Wong

et al. 2001

Aliment Pharmacol Ther

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Aim: To compare the efficacy and tolerability of a 3‐day quadruple therapy with a standard 7‐day triple therapy in eradicating Helicobacter pylori infection and healing duodenal ulcers. Methods: Patients with H. pylori‐positive duodenal ulcers were randomized to receive either lansoprazole 30 mg, clarithromycin 500 mg, and metronidazole 400 mg twice daily for 7 days (LCM‐7) or lansoprazole 30 mg, clarithromycin 500 mg, metronidazole 400 mg, and bismuth subcitrate 240 mg twice daily for 3 days (LCMB‐3). No pre‐ or post‐treatment acid suppression was used. Follow‐up endoscopy was performed at week 6. Results: A total of 118 patients were recruited. Sixty patients in the LCM‐7 group and 53 patients in the LCMB‐3 group returned for endoscopy. Intention‐to‐treat eradication rates were 87% and 86% (P=0.94) and per protocol eradication rates were 87% and 94% (P=0.29) in the LCM‐7 and LCMB‐3 groups, respectively. Per protocol and intention‐to‐treat ulcer healing rates were 98% and 98% in LCM‐7 and 100% and 91% in LCMB‐3, respectively. There were no significant differences in efficacy in relation to the initial metronidazole and clarithromycin susceptibility. Significant reduction in the duration of side‐effects was found in the LCMB‐3 group. Conclusion: The 3‐day quadruple therapy is highly effective, better tolerated and can be considered as a first‐line therapy in duodenal ulcer management.

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“…In total, 11 study arms involving 602 Dutch patients have been published on quadruple therapy (Table II). In three study arms quadruple therapy was given for 1 or 2 days only (LBTM0) (20)(21)(22), all with eradication rates`60%. In four studies (3 LBTM1 (3, 23, 24) and 1 OBTM1 (8)), quadruple therapy was given for 4 days with mean ITT and PP eradication rates of 89% and 91%, respectively.…”

Section: Quadruple Therapymentioning

confidence: 99%

Helicobacter pylori Eradication Therapy in The Netherlands

Houben¹

1999

Scandinavian Journal of Gastroenterology

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Background: Helicobacter pylori cure rates vary in different geographical regions because of differences in hosts as well as in H. pylori strains. Objective: To review systematically all available data in the literature to determine H. pylori eradication rates in The Netherlands. Methods: A search of all published trials on H. pylori eradication therapy performed in The Netherlands was conducted via electronic database search, hand-searching of abstracts from scientific meetings and checking reference lists of pharmaceutical companies. Full papers and abstracts were included. Data on anti-H. pylori therapies were pooled based on duration and combination of drugs. Only triple and quadruple eradication regimens were studied. Dual therapies were excluded, except for ranitidine bismuth citrate-based dual therapies. Results: We analysed 38 study arms, involving 2197 patients. Twenty different pooled regimens were studied with a mean intention-to-treat eradication rate of 83% (range 35-96%). There were no significant differences in the percentage of patients that stopped treatment due to adverse events between the groups. In these pooled regimens only bismuth combined with tetracycline and metronidazole for 1 or 2 weeks was significantly lower in efficacy in metronidazole-resistant strains than in metronidazole-sensitive strains. The prevalence of metronidazole-resistant strains in The Netherlands showed large regional differences (7-50%). Conclusions: A therapy should be tested in a defined population before becoming standard. Several eradication regimens studied in The Netherlands yield acceptable cure rates of 80% or more on an intention-to-treat basis. We advise taking the local prevalence of metronidazole resistance into account when choosing a first-line eradication regimen.

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Two‐day ‘weekend’ lansoprazole‐quadruple therapy for Helicobacter pylori infection

Abstract: A 2-day 'weekend' quadruple therapy cures only 60% of patients and cannot be recommended, but these findings provide an insight into the mode of action of quadruple therapy.

Cited by 17 publications

References 23 publications

Addition of Metronidazole to Rabeprazole‐Amoxicillin‐Clarithromycin Regimen for Helicobacter pylori Infection Provides an Excellent Cure Rate with Five‐Day Therapy

Addition of Metronidazole to Rabeprazole‐Amoxicillin‐Clarithromycin Regimen for Helicobacter pylori Infection Provides an Excellent Cure Rate with Five‐Day Therapy

Three‐day lansoprazole quadruple therapy for Helicobacter pylori‐positive duodenal ulcers: a randomized controlled study

Helicobacter pylori Eradication Therapy in The Netherlands

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