Two cystic lesions with features of both the botryoid odontogenic cyst and the central mucoepidermoid tumour: sialo‐odontogenic cyst?

Padayachee, A; Wyk, C W van

doi:10.1111/j.1600-0714.1987.tb00680.x

Cited by 151 publications

(91 citation statements)

References 11 publications

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“…Many of these have been single case reports; however, several short series and detailed reviews of the literature have also been published [1,2,6,7,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Therefore, the GOC, though rare, is now relatively well known, especially among oral and head and neck pathologists.…”

Section: Discussionmentioning

confidence: 99%

“…In 1987, Padayachee and van Wyk [1] published two cases of unusual odontogenic cysts, which possessed features of botryoid odontogenic cyst and central mucoepidermoid carcinoma, and proposed the term ''sialo-odontogenic cyst'' for these lesions. In 1988, Gardner and colleagues [2] described eight additional cases, preferring the term ''glandular odontogenic cyst'' (GOC).…”

Section: Introductionmentioning

confidence: 99%

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Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

129

172

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The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC's importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, and microscopic features of GOC, to determine which microscopic features may be helpful for diagnosis in problematic cases, to determine the most appropriate treatment, and to determine if GOC and CMEC share a histopathologic spectrum. In our series of 46 cases, the mean age at diagnosis was 51 years with 71% of cases in the 5th-7th decades. No gender predilection was noted. 80% of cases occurred in the mandible, and 60% of the lesions involved the anterior regions of the jaws. Swelling/expansion was the most common presenting complaint, although some cases were asymptomatic. Radiographically, most cases presented as a well-defined unilocular or multilocular radiolucency involving the periapical area of multiple teeth. Some lesions displayed a scalloped border. Cases also presented in dentigerous, lateral periodontal, and ''globulomaxillary'' relationships. The canine area was a common location for maxillary cases. All cases were treated conservatively (enucleation, curettage, cystectomy, excision). Follow-up on 18 cases revealed a recurrence rate of 50% (9/18), with 6 cases recurring more than once (range of follow-up: 2 months to 20 years; average length of follow-up: 8.75 years). The mean interval from initial treatment to first recurrence was 8 years, and from first recurrence to second recurrence was 5.8 years. Two cases recurred three times and the interval from second to third recurrence was 7 years (exact interval only documented in one case). All cases exhibited eosinophilic cuboidal (hobnail) cells, a feature not specific for GOC, but necessary for diagnosis, in our opinion. Univariate analysis indicated several features that are most helpful in distinguishing GOC from GOC mimickers in problematic cases, including: (1) the presence of microcysts (P \ 0.0001); (2) epithelial spheres 123Head and Neck Pathol (2011) 5:364-375 DOI 10.1007 (P \ 0.0001); (3) clear cells (P = 0.0002); (4) variable thickness of the epithelial cyst lining (P = 0.0002); and (5) multiple compartments (P = 0.006). Stratified analysis indicated that when microcysts are present, epithelial spheres and multiple compartments are still significant, and clear cells are marginally significant in distinguishing GOCs from GOC mimickers. The presence of microcysts (P = 0.00...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

129

172

View full text Add to dashboard Cite

show abstract

“…Padayachee and Van Wyk [1] presented multilocular cystic lesions that were similar to botryoid odontogenic cysts but with a glandular ingredient and suggested the name ''sialo odontogenic cyst''. In 1988, Gardner et al [2] reported eight other cases and called the lesions glandular odontogenic cysts (GOCs) because there was a mucin structure in the cyst epithelium that had no finding of salivary gland origin.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Glandular Odontogenic Cyst of Mandible: A Rare Occurrence

Akkaş

Toptaş

Özan

et al. 2014

J. Maxillofac. Oral Surg.

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Glandular odontogenic cysts (GOCs) of the jaw are rare with well-defined limits radiologically, unusual histopathological features and a high recurrence rate. The radiographic appearance of GOCs vary and are not pathognomonic. Definitive diagnosis of the GOC is established only by histopathological examinations. Histologically, GOC is characterized by a thin nonkeratinized squamous epithelial lining, with papillary projections, nodular thickenings, mucous (goblet) cells with intraepithelial mucous pools and intraepithelial glandular, microcystic or duct-like structures. We present an unusual case of a bilateral GOC in the mandible. This case report is also the first documented case of bilateral GOC in the mandible.

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“…Glandular Odontogenic Cyst (GOC) is relatively a rare entity, that was first described by Padayachee and Van Wyk [1] in 1987 under the term 'sialo-odontogenic cyst' attributing its possible etiology to salivary glands. The term 'Glandular odontogenic cyst' (GOC) was first coined by Gardner et al [2], in 1988 as an odontogenic origin.…”

Section: Introductionmentioning

confidence: 99%

“…GOC has gained special attention by clinicians and pathologists due primarily to two reasons. First, is the histomorphologic features between GOC, Lateral Periodontal Cyst (LPC), Botroid Odontogenic Cyst (BOC), and Central Mucoepidermoid Carcinoma (CMEC) of the jaws [1,4,5,6] second, is the potential aggressive behaviour of the lesion. Radiographically, GOC does not display specific or pathognomonic features.…”

Section: Introductionmentioning

confidence: 99%

Glandular odontogenic cyst involving the posterior part of maxillary sinus, a rare entity

Rao

Kumar

2010

J. Maxillofac. Oral Surg.

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Two cystic lesions with features of both the botryoid odontogenic cyst and the central mucoepidermoid tumour: sialo‐odontogenic cyst?

Cited by 151 publications

References 11 publications

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Bilateral Glandular Odontogenic Cyst of Mandible: A Rare Occurrence

Glandular odontogenic cyst involving the posterior part of maxillary sinus, a rare entity

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