Two cyclopeptides from the seeds of Annona cherimola

Wélé, Alassane; Zhang, Yanjun; Brouard, Jean-Paul; Pousset, Jean-Louis; Bodo, Bernard

doi:10.1016/j.phytochem.2005.06.011

Cited by 22 publications

(23 citation statements)

References 7 publications

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“…This, however, calls for further testing. The proteomic analysis of M. anisopliae strains isolated from A. squamosa field showed the presence of two cyclopeptides viz., cyclopeptide E and F, which were previously reported from the Annona cherimola and related species [15]. These cyclopeptides were absent in M. anisopliae strains (less virulent against H. armigera) isolated from S. lycopersicum field.…”

Section: Discussionsupporting

confidence: 55%

The puzzle of highly virulent Metarhizium anisopliae strains from Annona squamosa fields against Helicoverpa armigera

Pathan

Deshpande

2019

J Basic Microbiol

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In our search for indigenous virulent strains of the entomopathogenic fungi, we observed that Metarhizium isolates from soils associated with Annona squamosa (custard apple) have higher virulence (>90% mortality of Helicoverpa armigera larvae at 1/10th spore concentration) than strains isolated from Solanum lycopersicum (tomato) fields. Proteomic analysis revealed two insecticidal cyclopeptides of A. squamosa origin in the M. anisopliae strains that led to higher virulence against H. armigera. Transcriptomic and genomic data indicated that M. anisopliae strains and A. squamosa had more than 20 genes in common, including those for cyclic hexapeptide synthase, non‐ribosomal peptide synthetase, and plant cyclotide genes, which are involved in the biosynthesis of insecticidal cyclopeptides. These genes were absent in M. anisopliae strains isolated from the S. lycopersicum fields. Further, these strains can establish an endophytic relationship with A. squamosa suggesting that these rhizospheric strains originally could be endophytes, which were eventually released into the soil. Further, Metarhizium strains associated with Capsicum annuum (chili), Azadirachta indica (neem), and Carica papaya (papaya) − plants with insecticidal properties − also had higher virulence against H. armigera. Thus exploration of rhizospheres of plants producing insecticidal metabolites to isolate entomopathogenic fungi, per se, could be a viable strategy in agricultural for crop protection.

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Section: Discussionsupporting

confidence: 55%

The puzzle of highly virulent Metarhizium anisopliae strains from Annona squamosa fields against Helicoverpa armigera

Pathan

Deshpande

2019

J Basic Microbiol

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“…In addition, to treat gastrointestinal disorders such stomach pain, diarrhea, and dysentery; at present, it is used to treat diabetes. [ 16 19 20 ] Phytochemical investigations revealed the presence of alkaloids, flavonoids, sterols,[ 20 21 22 23 24 ] terpenoids,[ 25 26 27 ] cyclic peptides,[ 28 29 ] and acetogenins. [ 30 31 ] With regard to pharmacological investigations have been reported that A. cherimola extracts possess genotoxic, cytotoxic,[ 31 32 33 ] antihypercholesterolemic,[ 23 ] antihyperlipidemic[ 34 ] antidepressant,[ 22 ] cryoprotective,[ 35 ] anxiolytic,[ 25 ] antiprotozoal,[ 36 ] antisecretory,[ 37 ] antiarthritic,[ 38 ] antibacterial,[ 17 20 ] antifungal,[ 17 ] anti-inflammatory, antioxidant,[ 39 40 ] and inhibitor of mitochondrial complex I properties.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic activity of the leaves fromAnnona cherimolamiller and rutin on alloxan-induced diabetic rats

et al. 2017

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Background:Annona cherimola, known as “chirimoya” has been reported in Mexican traditional medicine for the treatment of diabetes.Objective:The aims of the present study were to validate and assess the traditional use of A. cherimola as an antidiabetic agent.Materials and Methods:The ethanol extract from A. cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg), and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats. In addition, oral glucose tolerance test (OGTT) and oral sucrose tolerance test (OSTT) were performed in normoglycemic rats. Molecular docking technique was used to conduct the computational study.Results:Bioassay-guided fractionation of EEAc afforded as major antihyperglycemic compound, rutin. EEAc attenuated postprandial hyperglycemia in acute test using AITD rats (331.5 mg/dL) carrying the glycemic levels to 149.2 mg/dL. Rutin after 2 h, attenuated postprandial hyperglycemia in an acute assay using AITD rats such as EEAc, with maximum effect (150.0 mg/dL) being seen at 4 h. The antihyperglycemic activities of EEAc and rutin were comparable with acarbose (151.3 mg/dL). In the subchronic assay on AITD rats, the EEAc and rutin showed a reduction of the blood glucose levels since the 1st week of treatment, reaching levels similar to normoglycemic state (116.9 mg/kg) that stayed constant for the rest of the assay. OGTT and OSTT showed that EEAc and rutin significantly lowered blood glucose levels in normoglycemic rats at 2 h after a glucose or sucrose load such as acarbose. Computational molecular docking showed that rutin interacted with four amino acids residues in the enzyme α-glucosidase.Conclusion:The results suggest that rutin an α-glucosidase inhibitor was responsible in part of the antihyperglycemic activity of A. cherimola. Its in vivo antihyperglycemic activity is in good agreement with the traditional use of A. cherimola for the treatment of diabetes.SUMMARYThe ethanol extract from Annona cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg) and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats. The results suggest that rutin; an α-glucosidase inhibitor was responsible in part of the antihyperglycemic activity of A. cherimola. Its in vivo antihyperglycemic activity is in good agreement with the traditional use of A. cherimola for the treatment of diabetes.Abbreviations Used: EEAc: The ethanol extract from Annona cherimola, AITD: Alloxan-induced type 2 diabetic rats, OGTT: Oral glucose tolerance test, OSTT: Oral sucrose tolerance test, DM: Diabetes mellitus

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“…Some previous reports have demonstrated the anti-tumor effects of A. atemoya [14–16] and its parental plants, A. squamosa [38, 39] and A. cherimola [40]. However, to our knowledge, no previous study has verified the anti-angiogenic effect of an A. atemoya extract.…”

Section: Discussionmentioning

confidence: 87%

Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo

Park

Lee

et al. 2014

BMC Complement Altern Med

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BackgroundAngiogenesis, which is initiated by certain tumor micro-environmental conditions and diverse protein factors, plays a pivotal role during tumor development and metastasis. Therefore, many efforts have been made to develop effective anti-angiogenic agents as anticancer therapeutics. In the current study, we investigated the anti-angiogenic potential of an ethanol extract of Annona atemoya seeds (EEAA) in vitro and in vivo.MethodsThe anti-angiogenic potential of EEAA was evaluated using various in vitro/in vivo models, including cell proliferation, migration, and tube formation by human umbilical vascular endothelial cells (HUVECs); a Matrigel plug assay; and tumor-induced angiogenesis. The expression of hypoxia-inducible factors (HIFs) and vascular endothelial growth factor (VEGF) was investigated using reverse transcription-polymerase chain reaction, immunoassays, and western blotting.ResultsEEAA was able to significantly inhibit the angiogenic properties of HUVECs in vitro as well as angiogenic factor-induced blood vessel formation in vivo. EEAA down-regulated the expression of VEGF and HIF-1alpha/2alpha at the mRNA and protein levels, respectively, in cancer cells under hypoxic conditions.ConclusionsEEAA shows a strong anti-angiogenic potential in both in vitro and in vivo systems, and we suggest that EEAA may be a valuable herbal source for anticancer drug development.

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Two cyclopeptides from the seeds of Annona cherimola

Cited by 22 publications

References 7 publications

The puzzle of highly virulent Metarhizium anisopliae strains from Annona squamosa fields against Helicoverpa armigera

The puzzle of highly virulent Metarhizium anisopliae strains from Annona squamosa fields against Helicoverpa armigera

Antihyperglycemic activity of the leaves fromAnnona cherimolamiller and rutin on alloxan-induced diabetic rats

Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo

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