Two Cu(II) coordination polymers based on benzene-1,3,5-tricarboxylate and 1,2,4-triazolide ligands: their crystal structures and application of nanoparticles in anti-esophageal cancer activity evaluation

Zhu, Kaibin; Chen, Lantao; Jin, Xiangyuan; Qu, Changfa

doi:10.1007/s11224-019-01301-4

Cited by 2 publications

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“…It has demonstrated anticancer activity and could be a formulant in innovative anticancer drugs [ 17 , 18 , 19 ]. Copper(II) complexes, such as hydroxytryptophan copper(II) [ 20 ], substituted derivatives of pregnenolone acetate copper(II) [ 21 ], thiosemicarbazone copper(II) [ 22 ], substituted carboxylic acid copper(II) [ 23 ], 1,10-phenanthroline derivative copper(II) [ 24 ], pyridine derivative copper(II) [ 25 ], thiosemicarbazone copper(II) [ 26 ], piperazine copper(II) [ 27 ], and schiff copper(II) [ 28 ], have been synthesized, and their anticancer efficacy has been assessed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, DNA/HSA Interactions, and Anticancer Activity of Two Novel Copper(II) Complexes with 4-Chloro-3-Nitrobenzoic Acid Ligand

et al. 2021

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The purpose of this study was to identify new metal-based anticancer drugs; to this end, we synthesized two new copper(II) complexes, namely [Cu(ncba)4(phen)] (1) and [Cu(ncba)4(bpy)] (2), comprised 4-chloro-3-nitrobenzoic acid as the main ligand. The single-crystal XRD approach was employed to determine the copper(II) complex structures. Binding between these complexes and calf thymus DNA (CT-DNA) and human serum albumin (HSA) was explored by electronic absorption, fluorescence spectroscopy, and viscometry. Both complexes intercalatively bound CT-DNA and statically and spontaneously quenched DNA/HSA fluorescence. A CCK-8 assay revealed that complex 1 and complex 2 had substantial antiproliferative influences against human cancer cell lines. Moreover, complex 1 had greater antitumor efficacy than the positive control cisplatin. Flow cytometry assessment of the cell cycle demonstrated that these complexes arrested the HepG2 cell cycle and caused the accumulation of G0/G1-phase cells. The mechanism of cell death was elucidated by flow cytometry-based apoptosis assays. Western blotting revealed that both copper(II) complexes induced apoptosis by regulating the expression of the Bcl-2(Bcl-2, B cell lymphoma 2) protein family.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, DNA/HSA Interactions, and Anticancer Activity of Two Novel Copper(II) Complexes with 4-Chloro-3-Nitrobenzoic Acid Ligand

et al. 2021

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The system of self-consistent QSPR-models for refractive index of polymers

2022

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Quantitative structure-property/activity relationships (QSPRs/QSARs) are a component of modern natural science. The system of self-consistent models is a specific approach to build up QSPR/QSAR.A group of models of refractive index for different distributions in training and test sets compared.This comparison is a basis to formulate the system of self-consistent models. The so-called index of ideality of correlation (IIC) has been used to improve the predictive potential of models of the refractive index of different polymers (n=255). The predictive potential of the suggested models is high since the average value of the determination coefficient for the validation set is 0.885. In addition, the system of self-consistent models may be applied as a tool to assess the predictive potential of an arbitrary QSPR-approach.

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Two Cu(II) coordination polymers based on benzene-1,3,5-tricarboxylate and 1,2,4-triazolide ligands: their crystal structures and application of nanoparticles in anti-esophageal cancer activity evaluation

Cited by 2 publications

References 33 publications

Synthesis, Characterization, DNA/HSA Interactions, and Anticancer Activity of Two Novel Copper(II) Complexes with 4-Chloro-3-Nitrobenzoic Acid Ligand

Synthesis, Characterization, DNA/HSA Interactions, and Anticancer Activity of Two Novel Copper(II) Complexes with 4-Chloro-3-Nitrobenzoic Acid Ligand

The system of self-consistent QSPR-models for refractive index of polymers

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