Two Cu(II) and Zn(II) complexes derived from 5-(Pyrazol-1-yl)nicotinic acid: Crystal structure, DNA binding and anticancer studies

Ji, Xiaoxi; Zhu, Xingye; Chen, Shiyu; Song, Dongxue; Wu, Shuangyan; Zhang, Ying; Gao, Enjun; Zhu, Mingchang

doi:10.1016/j.jssc.2021.122707

Cited by 14 publications

(5 citation statements)

References 54 publications

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“…The mean IC 50 value obtained by analyzing concentration–response curves of ( 93 ) and cisplatin was 19.21 and 0.45 μM, respectively. Additionally, complex [Zn(pna) 2 (H 2 O)] n ( 94 ) (Hpna = 5-(pyrazol-1-yl) nicotinic acid) presents good anti-cancer activity on HeLa cells at a similar concentration to cisplatin, which is very valuable behavior having in view that, despite their efficiency, cisplatin and platinum analogs are cytotoxic and produce adverse reactions [ 106 ].…”

Section: Zinc(ii) Carboxylate Coordination Polymers Developed For Dif...mentioning

confidence: 99%

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

et al. 2023

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This review considers the applications of Zn(II) carboxylate-based coordination polymers (Zn-CBCPs), such as sensors, catalysts, species with potential in infections and cancers treatment, as well as storage and drug-carrier materials. The nature of organic luminophores, especially both the rigid carboxylate and the ancillary N-donor bridging ligand, together with the alignment in Zn-CBCPs and their intermolecular interaction modulate the luminescence properties and allow the sensing of a variety of inorganic and organic pollutants. The ability of Zn(II) to act as a good Lewis acid allowed the involvement of Zn-CBCPs either in dye elimination from wastewater through photocatalysis or in pathogenic microorganism or tumor inhibition. In addition, the pores developed inside of the network provided the possibility for some species to store gaseous or liquid molecules, as well as to deliver some drugs for improved treatment.

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Section: Zinc(ii) Carboxylate Coordination Polymers Developed For Dif...mentioning

confidence: 99%

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

et al. 2023

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“…PUC‐19 DNA has been incubated with and without the tested metal chelates through an applied dose of 25 μM for 2 h at 37 °C as well as more loaded on a 1% agarose‐gel. After that, the gel was discolored through ethidium bromide[Et‐Br] as well as photographed below the UV lamp 39 …”

Section: Methodsmentioning

confidence: 99%

“…After that, the gel was discolored through ethidium bromide[Et-Br] as well as photographed below the UV lamp. 39 DNA docking simulation Molecular docking simulation was carried out utilizing Auto Dock Tools 1.5.6 and Auto Dock 4.2 software to estimate the interaction of synthesized complexes with target macromolecule (DNA). The structure of the complexes was extracted from the DFT calculation, while the DNA crystal structure (PDB ID: 454D 40 ) was chosen from the protein data bank and used for docking.…”

Section: Agarose Gelelectrophoresismentioning

confidence: 99%

Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes

Abu‐Dief,

El‐Khatib,

El‐Dabea

et al. 2024

Applied Organom Chemis

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New Cu (II), VO (II), Ag(I), and Pd (II)‐[BIP = 4,6‐dimethyl‐N‐(octahydro‐2H‐benzimidazol‐2‐ylidene)pyrimidin‐2‐amine] chelates have been synthesized by the reaction of BIP ligand resulting from the condensation of benzimidazole guanidine as well as acetylacetone with tested metal salts. The suggested structures of prepared compounds have been investigated spectroscopically through (FT‐IR, NMR, Mass spectra, and UV–Vis spectra), CHN analyses, conductivity, pH stability as well asmagnetic moment measurements. TGA studies have been also studied to govern the thermal behavior, stability, and decomposition of the metal chelates. Structural study of the tested chelates exposed their chemical transformation of ligand by chelation with the studied metals. The studies predicted a hexa‐coordinated geometry for the Cu and VO chelates, whereas tetra‐coordinated for the Ag and Pd chelates. DFT/B3LYP theoretical method was applied to obtain optimized geometry, molecular electrostatic potential (MEP) surface, and HOMO‐LUMO analysis for tested compounds. For estimation in the in vitro study, all the tested compounds have been screened for their biochemical features, including antioxidant, antimicrobial performances, and cytotoxicity. The antioxidant performance of prepared molecules has been studied by DPPH study and all the tested chelates displayed close antioxidant performance against the standard drugs. The cytotoxic analysis of tested compounds has been estimated against various cancer cell lines: (Hep‐G2, HCT‐116, and MCF‐7) using MTT analysis as well as calculated the cell viability for the corresponding human cell. The DNA binding capability for the tested compounds has been evaluated through absorption spectroscopic, viscosity estimation, as well as gel electrophoresis. The outcomes displayed a good binding tendency through the binding constant from 1.01 × 104 to 1.99 × 104 M−1 in the order BIPCu> BIPVO > BIPPd > BIPAg, respectively. Finally, docking simulation results indicated that the complexes were located in the intercalation site of DNA and confirmed experimental findings.

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“…8 In particular, there are many works devoted to the study of the anti-tuberculosis and anti-cancer activity of pyrazole-containing compounds. 9 We have previously shown that the combination of N-heterocyclic ligands – phenanthroline and pyrazole in palladium complexes with various anions leads to an increased antiproliferative effect against cancer cells SKOV3. 10 From the point of view of coordination chemistry, pyrazole and its derivatives have wide possibilities, since they contain two nitrogen atoms of different chemical nature – pyridine and pyrrole fragments.…”

Section: Introductionmentioning

confidence: 99%

Research of the influence of anions in complexes [CuPhen(Hpz)₂X₂] (X = CF₃COO⁻, Otf⁻, Cl⁻) on the structure and bioactivity

Uvarova,

Lutsenko,

Shmelev

et al. 2024

New J. Chem.

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Two Cu(II) and Zn(II) complexes derived from 5-(Pyrazol-1-yl)nicotinic acid: Crystal structure, DNA binding and anticancer studies

Cited by 14 publications

References 54 publications

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes

Research of the influence of anions in complexes [CuPhen(Hpz)₂X₂] (X = CF₃COO⁻, Otf⁻, Cl⁻) on the structure and bioactivity

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Two Cu(II) and Zn(II) complexes derived from 5-(Pyrazol-1-yl)nicotinic acid: Crystal structure, DNA binding and anticancer studies

Cited by 14 publications

References 54 publications

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes

Research of the influence of anions in complexes [CuPhen(Hpz)2X2] (X = CF3COO−, Otf−, Cl−) on the structure and bioactivity

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Research of the influence of anions in complexes [CuPhen(Hpz)₂X₂] (X = CF₃COO⁻, Otf⁻, Cl⁻) on the structure and bioactivity