Two-component phosphorelays in fungal mitochondria and beyond

Chauhan, Neeraj

doi:10.1016/j.mito.2015.03.003

Cited by 7 publications

(7 citation statements)

References 60 publications

(82 reference statements)

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“…Mitochondria play an important role in multiple processes, such as hyphal development, resistance to stress, virulence, apoptosis and sensitivity of yeast cells to drugs[ 31 – 33 ]. Cardiolipin and its precursor PG, the principal anionic phospholipid in mitochondrial membranes, are key elements in the response conferring resistance to osmotic and thermal stresses[ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profiling for the identification of potential biomarkers involved in a laboratory azole resistance in Candida albicans

Liao

et al. 2018

PLoS ONE

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Candida albicans, one of the most common fungal pathogens, is responsible for several yeast infections in human hosts, being resistant to classically used antifungal drugs, such as azole drugs. Multifactorial and multistep alterations are involved in the azole resistance in Candida albicans. In this study, a FCZ-resistant C. albicans strain was obtained by serial cultures of a FCZ-susceptible C. albicans strain in incrementally increasing concentrations of FCZ. We performed an integrated profile of different classes of molecules related to azole resistance in C. albicans by combining several mass-spectrometry based methodologies. The comparative metabolomic study was performed with the sensitive and resistant strains of C.albicans to identify metabolites altered during the development of resistance to fluconazole, while the intervention strains and non-intervention strains of C.albicans to identify metabolites altered involved in cross-resistant to azole drugs. Our analysis of the different metabolites identified molecules mainly involved in metabolic processes such as amino acid metabolism, tricarboxylic acid cycle and phospholipid metabolism. We also compared the phospholipid composition of each group, revealing that the relative content of phospholipids significantly changed during the development of resistance to azole drugs. According with these results, we hypothesized that the metabolism shift might contribute to azole drugs resistance in C.albicans from multifactorial alterations. Our result paves the way to understand processes underlying the resistance to azole drugs in C. albicans, providing the basis for developing new antifungal drugs.

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Section: Discussionmentioning

confidence: 99%

Metabolomic profiling for the identification of potential biomarkers involved in a laboratory azole resistance in Candida albicans

Liao

et al. 2018

PLoS ONE

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“…However, it is not clear whether acetylation of mitochondrial proteins takes place in the cytosol before their mitochondrial import or inside mitochondria? How the acetylation status influences mitochondrial function and nuclear cross-talk or even two-component signaling pathways that regulate fungal virulence [43] remains open. Notably, mitochondria and intrinsic signaling pathways play key roles in fungal pathogenesis [43, 44], but a link of acetylation, mitochondria, and virulence remains to be discovered.…”

Section: Non-histone Lysine Acetylation In Host-pathogen Interactionsmentioning

confidence: 99%

Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?

et al. 2016

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“…[39][40][41] One of the better known MAPK pathways that utilizes 2-component proteins is the Hog1p pathway. Environmental signals that trigger the HOG1 MAPK include high osmotic pressure and ROS.…”

Section: The Mitochondrial Srr1p Response Regulatormentioning

confidence: 99%

“…However, a mitochondrial response regulator (Srr1p) has been identified. 39,40 Srr1p appears to be unique to the Candida clade, with the exception of C. krusei 39 A knockout ssr1D is defective in hyphal development, adaptation to osmotic/oxidative stresses, and is avirulent. The participation of Srr1p in a signal pathway and its role in mitochondrial functions are unknown.…”

Section: The Mitochondrial Srr1p Response Regulatormentioning

confidence: 99%

Exploiting mitochondria as targets for the development of new antifungals

Calderone

2016

Virulence

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Two-component phosphorelays in fungal mitochondria and beyond

Cited by 7 publications

References 60 publications

Metabolomic profiling for the identification of potential biomarkers involved in a laboratory azole resistance in Candida albicans

Metabolomic profiling for the identification of potential biomarkers involved in a laboratory azole resistance in Candida albicans

Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?

Exploiting mitochondria as targets for the development of new antifungals

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