Two complications in patients with systemic lupus erythematosus: lupus cystitis and lupus enteritis

Wang, Gang; Zhuo, Ning; Feng, Tian; Li, Jingyang; Wen, Zhenhua

doi:10.5114/aoms/146547

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…16 Renal involvement can also coexist with Some cases of LE. 17,18 These non-specific symptoms cannot be used to differentiate between LE and other gastrointestinal diseases easily, which can easily lead to incorrect and missed diagnosis. Patients with LE who do not receive prompt diagnosis and treatment are at risk of developing severe complications, including intestinal bleeding, disseminated intravascular coagulation, intestinal perforation, and intestinal infarction, 7 which can endanger the lives of the patients.…”

Section: Discussionmentioning

confidence: 99%

Alterations and predictive value of blood routine parameters in patients with lupus enteritis: A retrospective study

Zhang,

Xiong

2023

Eur J Inflamm

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Background Lupus enteritis (LE) is prone to incorrect and missed diagnoses. LE primarily occurs during the active stage of systemic lupus erythematosus (SLE), which often manifests with alterations in peripheral blood cell that may serve as indicators of disease activity and organ damage. This study aims to investigate the alterations and predictive value of routine blood parameters for LE diagnosis. Methods This exploratory study retrospectively analyzed the medical records of 36 patients with SLE who were admitted to Suining Central Hospital between January 2006 and April 2023. Additionally, a control group consisting of 72 SLE patients without LE, matched for sex and age, was enrolled. A comparison was made between the two groups regarding clinical characteristics and changes in routine blood parameters. Binary logistic regression and receiver operating characteristic (ROC) curve analyses were conducted to identify independent risk factors and evaluate their diagnostic performance for LE. Results The LE group exhibited significantly higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), along with a lower lymphocyte count (LYM), compared to the control group ( p < .05). Binary logistic regression analysis revealed that NLR independently predicted the onset of LE, with an odds ratio of 1.347 and a 95% confidence interval of 1.070–1.696 ( p < .01). ROC curve analysis demonstrated that NLR had an area under the curve of 0.68 for diagnosing LE ( p < .05). When the cutoff value was set at 2.44, the Youden Index was only 0.31. Conclusion Significant differences were observed in several routine parameters between patients with LE and the control group, which can be attributed to the occurrence of LE during the active stage of SLE. However, only the NLR emerged as an independent risk factor for LE,and its predicting vulue for was insufficient; no blood routine parameter has been identified as an reliable predictor for LE.

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Section: Discussionmentioning

confidence: 99%

Alterations and predictive value of blood routine parameters in patients with lupus enteritis: A retrospective study

Zhang,

Xiong

2023

Eur J Inflamm

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“…Even though symptoms are similar in LC and IC, LC is considered to be a different entity, the symptoms of which are mostly affected by lupus activity [6]. LC symptoms are frequent, urgent, nocturnal, and painful micturition, known as overactive bladder (OAB) symptoms [7,8]. In a study investigating OAB symptoms in patients with SLE and primary Sjogren's syndrome, it was shown that OAB symptoms might emerge in SLE patients with IC, and the authors concluded that there may be a close link between OAB and IC [9].…”

Section: Introductionmentioning

confidence: 99%

Interstitial Cystitis as a Plausible Cause of Overactive Bladder in Systemic Sclerosis: A Hypothesis

Gökçen

2022

CAJMHE

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Patients with chronic inflammatory disease of the bladder, known as interstitial cystitis (IC), tend to have autoimmune diseases, such as Sjogren’s syndrome, systemic lupus erythematosus (SLE), rheumatoid arthritis and, rarely, systemic sclerosis (SSc). SLE patients with IC are prone to present with overactive bladder (OAB) symptoms. Lower urinary tract involvement is less usual in SSc but OAB symptoms are quite common among SSc patients with lower urinary tract involvement. The underlying mechanisms of lower urinary tract involvement, including OAB, in SSc could be as follows: i) vasculopathy, ii) fibrosis and/or sclerosis of bladder wall, iii) systemic sclerosis-associated myopathy, and iv) autonomic dysfunction. However, the role of IC leading to OAB is unclear. This hypothesis suggests that in patients with SSc, OAB may be associated with IC.

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“…Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disorder with variable clinical course, ranging from mild to severe forms. It mainly occurs in women, especially those in fertile age 1,2 . Due to the advances in Obstetrics and Rheumatology, pregnancy is now feasible for the majority of female SLE patients 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Effects of perinatal disease activity on offspring's growth in patients with systemic lupus erythematosus

Zhu

Tang

et al. 2022

Arch Med Sci

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IntroductionTo systematically analyze the associations of perinatal disease activity with adverse outcomes of Chinese patients with systemic lupus erythematosus (SLE) and their offspring.Material and methodsData of prenatal SLE patients and healthy pregnant woman admitted to our hospital during October 2001 to January 2018 were retrospectively collected, and the status of SLE offspring was followed-up in March 2020. Disease activity was evaluated by SLE disease activity index 2000 (SLEDAI-2k), and those with scores > 6 were defined as having active disease.ResultsTotally 198 deliveries of 194 SLE patients and 199 deliveries of healthy women were documented. Maternal and fetal adverse outcomes occurred in 74 (37.4%) and 90 (45.5%) deliveries of SLE patients respectively, which was significantly higher than those of healthy subjects. Among SLE patients, the active group had higher rates of gestational hypertension (p<0.001), preeclampsia/eclampsia (p<0.001), low birth weight (p<0.001), premature birth (p<0.001) and fetal growth restriction (FGR) (p<0.01) than inactive group. Multivariate logistic analysis revealed that perinatal renal activity was associated with gestational hypertension (OR 4.43, p<0.001), preeclampsia/ eclampsia (OR 9.14, p<0.001), low birth weight (OR 2.24, p<0.05) and premature birth (OR 4.20, p<0.001). Compared with the general population, SLE offspring had relatively high rates of eczema (50/142 35.2%) and congenital heart disease (6/142 4.2%), which were irrelevant to perinatal disease activity, but related to specific antibodies.ConclusionsFor perinatal SLE women, renal activity is associated with a variety of adverse pregnancy outcomes. However, maternal perinatal disease activity does not seem to affect the growth of their offspring.

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Two complications in patients with systemic lupus erythematosus: lupus cystitis and lupus enteritis

Cited by 5 publications

References 24 publications

Alterations and predictive value of blood routine parameters in patients with lupus enteritis: A retrospective study

Alterations and predictive value of blood routine parameters in patients with lupus enteritis: A retrospective study

Interstitial Cystitis as a Plausible Cause of Overactive Bladder in Systemic Sclerosis: A Hypothesis

Effects of perinatal disease activity on offspring's growth in patients with systemic lupus erythematosus

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