1994
DOI: 10.1159/000170180
|View full text |Cite
|
Sign up to set email alerts
|

Two-Compartment Model of Cholesterol Kinetics for Establishment of Treatment Strategy of LDL Apheresis in Nephrotic Hypercholesterolemia

Abstract: Cholesterol kinetics in the time course after LDL apheresis using a dextran sulfate cellulose column was analyzed by adapting a two-compartment cholesterol kinetic model. Fifteen sets of serial serum cholesterol concentrations after LDL apheresis from 4 patients with drug-resistant nephrotic hypercholesterolemia due to focal glomerulosclerosis (FGS) were analyzed and cholesterol kinetic parameters were estimated with the nonlinear least-squares method. The fractional cholesterol catabolic rates (Kc;0.171 ± 0.0… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
6
0

Year Published

1996
1996
2020
2020

Publication Types

Select...
5
1

Relationship

2
4

Authors

Journals

citations
Cited by 7 publications
(8 citation statements)
references
References 8 publications
2
6
0
Order By: Relevance
“…Considering the rapid improvement of nephrotic proteinuria obtained by short intervals between LDL-A procedures [10], it seemed reasonable to perform LDL-A at least twice a week, especially at the beginning of treatment. This protocol was also supported by the recent analysis of cholesterol kinetics during LDL-A in nephrotic hypercholesterolemia in which the serum cholesterol levels were maintained at <250 mg/dl by the same protocol as in the present study [11]. In this study, we first compared the clinical data and the effect of the therapy between those treated both with steroid and LDL-A and those treated only with steroid to evaluate the effect of LDL-A.…”
Section: Discussionsupporting
confidence: 61%
“…Considering the rapid improvement of nephrotic proteinuria obtained by short intervals between LDL-A procedures [10], it seemed reasonable to perform LDL-A at least twice a week, especially at the beginning of treatment. This protocol was also supported by the recent analysis of cholesterol kinetics during LDL-A in nephrotic hypercholesterolemia in which the serum cholesterol levels were maintained at <250 mg/dl by the same protocol as in the present study [11]. In this study, we first compared the clinical data and the effect of the therapy between those treated both with steroid and LDL-A and those treated only with steroid to evaluate the effect of LDL-A.…”
Section: Discussionsupporting
confidence: 61%
“…Model parameters for the filtration coefficient (Lp) and for the initial circulating plasma volume (Vp0) were estimated so as to fit calculated values of Ht to actual values measured using the CRIT-LINE monitor by the nonlinear least square method [6]. Fifteen points of Ht were used for fitting (Ht at 0, 1, 3, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 and 60 min after the start of ultrafiltration).…”
Section: Discussionmentioning
confidence: 99%
“…Model parameters for the filtration coefficient (Lp) and for the initial circulating plasma volume (Vp0) were estimated so as to fit calculated values of Ht to actual values measured using the CRIT-LINE monitor by the non-linear least square method [6]. Briefly, the numerical solutions to the simultaneous differential equations and Ht were calculated using tentative values of filtration coefficient (Lp) and initial circulating plasma volume (Vp0) by the Runge-Kutta-Gill method.…”
Section: Appendixmentioning
confidence: 99%
See 2 more Smart Citations