Two-colour X-gamma ray inverse Compton back-scattering source

Drebot, I.; Petrillo, V.; Serafini, L.

doi:10.1209/0295-5075/120/14002

Cited by 19 publications

(12 citation statements)

References 27 publications

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“…Starting from the features of the laser pulse and the phase space of the electron beam provided by the user, this code generates a complete phase space of the scattered X-ray photons. The collision parameters and the details of the simulations can be found in the literature (Drebot et al 2017). Figure 4 shows the normalised spectra of the high-energy (HE) and low-energy (LE) beams obtained from the simulations.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, in order to provide a dual-colour mode with a time structure compatible with an imaging task, the most promising solutions are those in which the X-ray energy tuning is made by quickly modifying the collision angle. The possibility of exploiting the interaction of the electron beam with two light pulses colliding with the electrons at a different angle has been recently proposed and investigated (Drebot et al 2017, Drebot et al 2018a). The two laser pulses can come from the same laser or from two different lasers.…”

Section: Dual-energy Icssmentioning

confidence: 99%

“…KES implementation is possible when two X-ray beams having different mean energy are available simultaneously or if the energy of a single X-ray beam can be switched swiftly. Various technological solutions aimed at providing a dual-energy ICS having a time structure compatible with an imaging task have been proposed (Drebot et al 2017, Drebot et al 2018a. Recently, a proposal for a Multidisciplinary Advanced Research Infrastructure with X-rays (MariX) has been supported by University of Milan and the Italian Institute for Nuclear Physics (INFN) (Serafini et al 2018, Serafini et al 2019.…”

Section: Introductionmentioning

confidence: 99%

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Inverse Compton radiation: a novel x-ray source for K-edge subtraction angiography?

Paternò¹,

Cardarelli²,

Gambaccini³

et al. 2019

Phys. Med. Biol.

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Coronary angiography is clinically used worldwide to diagnose diseases of coronary arteries. Despite its effectiveness, this technique is quite invasive and it is associated to significant risks due to the arterial catheterisation needed to inject the contrast agent. A valid alternative is using the K-edge subtraction method, which is based on the subtraction of two images acquired at energies bracketing the K-edge of the contrast element. The enhanced sensitivity of K-edge subtraction allows the intravenous injection of the contrast agent, thus reducing the risks of catheterisation.This technique can be effectively implemented by using intense and quasi-monochromatic X-ray beams. Synchrotron radiation has been proven to work well for this purpose, but its cost and size prevent a widespread clinical application. Inverse Compton sources are among the most promising innovative sources of intense and quasi-monochromatic X-rays. These sources are intrinsically more compact than those based on synchrotron radiation. In this work, the potential application of inverse Compton radiation to K-edge subtraction angiography is investigated. To this purpose, after a short review of the physics behind the inverse Compton process, an analytical framework is described. The proposed model is based on the application of the K-edge subtraction algorithm to calculate the SN R of details inside a suitable mathematical phantom. That allowed us to identify the characteristics of an inverse Compton source required for K-edge subtraction imaging. In particular, it was estimated that a photon fluence of 10 8 ph mm −2 is necessary to detect signals of clinical interest. Novel sources based on inverse Compton promise to achieve this requirement with an acquisition time of few hundreds of ms. This feature, together with compactness, broad two-dimensional radiation field, absence of harmonic contamination and the ability to deliver high photon fluxes also at high energies, makes this kind of sources promising for K-edge subtraction angiography and other diagnostic applications.

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Section: Methodsmentioning

confidence: 99%

Section: Dual-energy Icssmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inverse Compton radiation: a novel x-ray source for K-edge subtraction angiography?

Paternò¹,

Cardarelli²,

Gambaccini³

et al. 2019

Phys. Med. Biol.

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show abstract

“…Other solutions, such as that proposed for BriXS source, could allow the switch between two X-ray beams, with two different mean energies, in a short time (≤100 ms), opening the way to in vivo imaging applications. In this case, the electron beam can interact with two laser beams with the same wavelength, but at two different collision angles [39,40]. The switch between the two energies can be made by changing the interaction laser.…”

Section: Dual-energy Imaging Implementation With Inverse Compton Scatmentioning

confidence: 99%

Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study

et al. 2020

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It has been long recognized that dual-energy imaging could help to enhance the detectability of lesions in diagnostic radiology, by removing the contrast of surrounding tissues. Furthermore, X-ray attenuation is material specific and information about the object constituents can be extracted for tissue characterisation, i.e., to assess whether lesions represent a malignant or benign process. However, a true separation between the low and high energy components is not possible with conventional sources because of their broad X-ray spectrum, and the artifacts produced in the subtracted image can be only partially removed. Finally, dose issues have also prevented so far the application of dual-energy techniques within the clinical context. Very recently, a new intense and monochromatic X-ray source was proposed to fill the gap between a synchrotron radiation facility and the standard X-ray tube. Indeed, inverse Compton scattering (ICS) sources, which are based on the interaction of a powerful laser beam and a bright beam of relativistic electrons, are among the most promising innovative sources of monochromatic X and gamma radiation. In this contribution, we review the main features that allow an ICS source to meet the requirements of a medical imaging application. Specific examples of K-edge subtraction are then provided, to show the potential of ICS in clinical applications that require intravenous injection of a contrast medium.

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“…As per Equation (1), the energy of scattered photons also depends on the initial collision angle α 0 . This dependence can be exploited, conceiving a two color radiation scheme based on the use of two laser pulses impinging on the same electron beam at two different angles [16]. The potentialities of this scheme can be improved by using laser pulses carrying different polarizations.…”

Section: Expected Performancementioning

confidence: 99%

BriXs Ultra High Flux Inverse Compton Source Based on Modified Push-Pull Energy Recovery Linacs

et al. 2019

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We present a conceptual design for a compact X-ray Source BriXS (Bright and compact X-ray Source). BriXS, the first stage of the Marix project, is an Inverse Compton Source (ICS) of X-ray based on superconducting cavities technology for the electron beam with energy recirculation and on a laser system in Fabry-Pérot cavity at a repetition rate of 100 MHz, producing 20–180 keV monochromatic X-Rays devoted mainly to medical applications. An energy recovery scheme based on a modified folded push-pull CW-SC twin Energy Recovery Linac (ERL) ensemble allows us to sustain an MW-class beam power with almost one hundred kW active power dissipation/consumption.

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Two-colour X-gamma ray inverse Compton back-scattering source

Abstract: Preliminary experimental study and simulation of an energy-tunable quasimonochromatic laser-Compton X/-ray source

Cited by 19 publications

References 27 publications

Inverse Compton radiation: a novel x-ray source for K-edge subtraction angiography?

Inverse Compton radiation: a novel x-ray source for K-edge subtraction angiography?

Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study

BriXs Ultra High Flux Inverse Compton Source Based on Modified Push-Pull Energy Recovery Linacs

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