Two-Center Evaluation of Dynamic Sentinel Node Biopsy for Squamous Cell Carcinoma of the Penis

Leijte, Joost A.P.; Hughes, Ben; Graafland, Niels M.; Kroon, Bin B. R.; Olmos, Renato A. Valdés; Nieweg, Omgo E.; Corbishley, Cathy; Heenan, Susan; Watkin, Nick; Horenblas, Simon

doi:10.1200/jco.2008.20.6870

Cited by 154 publications

(74 citation statements)

References 29 publications

(1 reference statement)

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“…A recent study [5] reported a rate of seroma of 9.7%, more than one-half of which required aspiration (5.7%) (n = 139). In a single-site study evaluating outcomes following SLNB for penile cancer, rate of surgical site infection and abscess was 4% and seroma was 2%, which was similar to a multi-center study that demonstrated an infection rate of 3% and a seroma rate of 3.1% [7]. It is notable that rates of complications are significantly lower in retrospective studies, with overall complication rates reported from < 1% to 2% [8,9].…”

mentioning

confidence: 56%

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Meditz

Connick²,

McCarter³

2014

Surgical Infections

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Background: Most HIV-1 replication occurs in secondary lymphoid tissues, and evaluating these tissues is crucial to investigations of pathogenesis. Inguinal lymph nodes (LN) are obtained frequently for these studies as they are readily detectable in most individuals and provide abundant numbers of cells. Knowledge of the outcomes of inguinal LN excision for research purposes is important to inform accurately study participants and researchers of the potential risks. Methods: Data on surgical complications were collected in real time in HIV-1-infected subjects who underwent excisional inguinal LN biopsies for research purposes from February 1997 through June 2011. Data were analyzed retrospectively to determine the frequency of surgical complications using the Fisher exact test and nonparametric testing. Results: Eighty-seven research subjects underwent a total of 95 LN excisions. Thirty-six percent of subjects were female, 53% were white, 26% were black, 16% Hispanic, and 2% Native American. Median age was 36 y (22-52). The median CD4 + T cell count was 478 cell/mm 3 (range, 57-1117) and the median plasma HIV-1 RNA concentration was 4.1 log 10 copies/mL (range, 1.7-5.9). Minor complications including seroma, transient lymphedema, hematoma, and allergic reaction to surgical tape, occurred in 10% of procedures. Complications that required medical attention occurred in an additional 10% of procedures, and included cellulitis (5%), superficial incisional surgical site infection (3%), and seroma requiring aspiration (1%). Subjects with complications had a lower BMI (25; range, 16-38; n = 12) than others (28; range, 19-57; n = 40; p = 0.05) and tended to have higher platelets, (median, 259 · 10

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mentioning

confidence: 56%

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Meditz

Connick²,

McCarter³

2014

Surgical Infections

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“…Nowadays, more and more penile cancer patients with clinical negative lymph nodes were subjected to less invasive staging procedures such as sentinel nodal biopsy, and superficial or modified dissection . [21,[45][46][47][48][49] . Regardless the metastases deposit, extensive dissection is performed if one positive lymph node is found.…”

Section: N0mentioning

confidence: 99%

“…Patients with sentinel lymph node positive disease are still lack of valuable prognostic factors to stratify long-term outcome. Regionalization of penile cancer care and international collaboration, as adopted by European colleagues [45] , will allow investigators to overcome these drawbacks and perform well designed studies.…”

Section: N0mentioning

confidence: 99%

Lymph node metastases and prognosis in penile cancer

Zhu

2012

Chin. J. Cancer Res.

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Lymph node status is a key prognostic factor in penile squamous cell carcinoma. Recently, growing evidence indicates a multimodality approach consisting of neoadjuvant chemotherapy followed by consolidation surgery improves the outcome of locally advanced penile cancer. Thus, accurate estimation of survival probability in node-positive penile cancer is critical for treatment decision making, counseling of patients and follow-up scheduling. This article reviewed evolving developments in assessing the risk for cancer progression based on lymph node related variables, such as the number of metastatic lymph nodes, bilateral lymph node metastases, the ratio of positive lymph nodes, extracapsular extension of metastatic lymph nodes, pelvic lymph node metastases, metastatic deposit in sentinel lymph nodes and N stage in TNM classification. Controversial issues surrounding the prognostic value of these nodal related predictors were also discussed.

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“…The patient and recurrent tumour characteristics are presented in Table 1. The results of the primary dynamic SNB of these patients were included in a previously reported series [7].…”

Section: Methodsmentioning

confidence: 99%

“…The latter causes substantial short-and long-term complications [3]. This is avoided with dynamic SNB [4], a minimally invasive staging technique for patients with clinically normal lymph nodes [5][6][7]. Inguinal node dissection is done only if the sentinel node is tumourpositive.…”

Section: Introductionmentioning

confidence: 99%

Repeat dynamic sentinel node biopsy in locally recurrent penile carcinoma

et al. 2010

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Two-Center Evaluation of Dynamic Sentinel Node Biopsy for Squamous Cell Carcinoma of the Penis

Abstract: Sentinel node biopsy is a suitable procedure to stage clinically node-negative penile cancer, and it has a low complication rate. No learning curve was demonstrated in this study.

Cited by 154 publications

References 29 publications

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Lymph node metastases and prognosis in penile cancer

Repeat dynamic sentinel node biopsy in locally recurrent penile carcinoma

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