Two cases of serious food-borne infection in patients treated with anti-TNF-α. Are we doing enough to reduce the risk?

Makkuni, Damodar; Kent, Rebecca; Ra, Watts; Clunie, GordonJ.A

doi:10.1093/rheumatology/kei123

Cited by 15 publications

(8 citation statements)

References 7 publications

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“…Patients treated with IFX or etanercept are at risk for a severe course of food-borne infections with Listeria or Salmonella. Listeria can cause relatively mild gastroenteritis, but in IFX patients arthritis,31–33 meningitis,34–36 bacteraemia with terminal ileitis37 and sepsis have been reported 38 39. Salmonella infection can cause septic arthritis,40 but invasive systemic infections can develop due to immunosuppressive treatment, some with fatal outcomes 41–43.…”

Section: Adult Literaturementioning

confidence: 99%

Opportunistic infections in paediatric inflammatory bowel disease patients

Greef¹,

Vandenplas²,

Veereman-Wauters

2011

Arch Dis Child

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Section: Adult Literaturementioning

confidence: 99%

Opportunistic infections in paediatric inflammatory bowel disease patients

Greef¹,

Vandenplas²,

Veereman-Wauters

2011

Arch Dis Child

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“…Two cases of Salmonella septic arthritis have been reported with etanercept and a further 2 cases have been reported with infliximab. 39 , 41 …”

Section: Discussionmentioning

confidence: 99%

Ultrasound Detection of Salmonella Septic Arthritis in a Rheumatoid Arthritis Patient on Anti-TNF Treatment

Nandagudi

Kelly

2014

Journal of Investigative Medicine High Impact Case Reports

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We report a case of Salmonella septic arthritis detected by ultrasound in a 40-year-old man with rheumatoid arthritis while he was on anti–tumor necrosis factor-α monoclonal antibody certolizumab. An aspirate of his left elbow joint showed Salmonella enteritidis infection that was sensitive to ceftraixone. This was preceded by a brief episode of loose stools following a visit to the Far East. He was treated with antibiotics and made a good recovery. There have only been a few case reports of Salmonella septic arthritis in a rheumatoid arthritis patient on anti–tumor necrosis factor treatment but none previously in association with certolizumab.

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“…Listeria endocarditis occurred in a psoriatic arthritis patient treated with the biological agent infliximab who admitted eating soft cheeses (Kelesidis et al, 2010). Consumption of soft cheese made with unpasteurized milk resulted in L. monocytogenes bacteremia in an ankylosing spondylitis patient treated with infliximab, whereas eating partly cooked eggs from a local farm was followed by Salmonella joint infection in an RA patient treated with infliximab, prednisolone, and MTX (Makkuni et al, 2006). A patient with RA treated with MTX, prednisolone, and infliximab, who traveled to India and consumed raw vegetables, experienced acute S. paratyphi gastroenteritis followed by bacteremia and soft tissue infection (Bassetti et al, 2010).…”

Section: People With Pathological or Iatrogenic Immunosuppressionmentioning

confidence: 99%

“…Other workers have recommended that patients being treated with TNF-a inhibitors should be advised about specific high-risk foods to avoid (Slifman et al, 2003;Dixon et al, 2006;Makkuni et al, 2006;Viget et al, 2006;Raychaudhuri et al, 2009;Kelesidis et al, 2010).…”

Section: Advice To Avoid High-risk Foodsmentioning

confidence: 99%

The Occurrence and Prevention of Foodborne Disease in Vulnerable People

Lund

O’Brien

2011

Foodborne Pathogens and Disease

174

110

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In developed countries, such as the United Kingdom and the United States, between 15% and 20% of the population show greater susceptibility than the general population to foodborne disease. This proportion includes people with primary immunodeficiency, patients treated with radiation or with immunosuppressive drugs for cancer and diseases of the immune system, those with acquired immune-deficiency syndrome and diabetics, people suffering from liver or kidney disease or with excessive iron in the blood, pregnant women, infants, and the elderly. Malnutrition and use of antacids, particularly proton-pump inhibitors, also increase susceptibility. We review the occurrence of infection by foodborne pathogens in these groups of people and measures to prevent infection. The nature and use of low microbial diets to reduce the risk of foodborne disease in immunocompromised patients are very variable. Diets for vulnerable people in care should exclude higherrisk foods, and vulnerable people in the community should receive clear advice about food safety, in particular avoidance of higher-risk foods and substitution of safer, nutritious foods.

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Two cases of serious food-borne infection in patients treated with anti-TNF-α. Are we doing enough to reduce the risk?

Cited by 15 publications

References 7 publications

Opportunistic infections in paediatric inflammatory bowel disease patients

Opportunistic infections in paediatric inflammatory bowel disease patients

Ultrasound Detection of Salmonella Septic Arthritis in a Rheumatoid Arthritis Patient on Anti-TNF Treatment

The Occurrence and Prevention of Foodborne Disease in Vulnerable People

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