Two Cases of SARS-CoV-2-Positive Mothers and Their Newborns in Korea

Jin, Ju Hyun; Kim, Yeejeong; Yoo, Jongha; Kim, Eui Hyeok; Yoon, Shin Won

doi:10.3947/ic.2021.0027

Cited by 6 publications

(7 citation statements)

References 17 publications

(21 reference statements)

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“…Among the studies decribing histological examination of placentas in the context of SARS-CoV-2 maternal infection (on Pubmed, with keywords “SARS-CoV-2” + “placenta” + “pathology”), which include three meta-analyses, poor fetal outcome has been frequently reported in association with the “placentitis triad”, consisting in intervillositis (with an acute or chronic infiltrate), excess fibrin deposition and trophoblastic necrosis [ Supplementary Table S1 ], refs. [ 3 , 4 , 5 , 6 , 8 , 9 , 10 , 12 , 13 , 14 , 15 , 16 , 17 , 20 , 21 , 22 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…The following supporting information can be downloaded at: , Table S1: Summary of the placental lesions in reported cases of SARS-CoV-2 infection in the literature [ 3 , 4 , 5 , 6 , 8 , 9 , 10 , 12 , 13 , 14 , 15 , 16 , 17 , 20 , 21 , 22 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ].…”

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confidence: 99%

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The Histopathological “Placentitis Triad” Is Specific for SARS-CoV-2 Infection, and Its Acute Presentation Can Be Associated with Poor Fetal Outcome

Remoué

Suazo

Uguen

et al. 2023

Life

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(1) Background: Placental histological lesions reported in relation with SARS-CoV-2 infection are various, with potential consequences such as fetal growth retardation, prematurity or stillbirth/neonatal death. We report here on a placental pathological association which could be specific for SARS-CoV-2 infection and associated with poor fetal outcome; (2) Methods: We collected all the placental pathological examinations performed in Brest University Hospital (France) since the beginning of COVID-19 pandemic with a known maternal SARS-CoV-2 infection and a poor pregnancy outcome. In these cases, we described the pathological lesions and we searched for these lesions in a large series of placentas collected and examined in the same institution before the SARS-CoV-2 pandemic; (3) Results: Three cases with severe fetal outcome (tardive abortion, prematurity, neonatal death), from the first to the third trimesters of pregnancy, were included. The three cases showed features of massive and acute “placentitis triad” consisting in massive perivillous fibrin deposition, sub-acute intervillositis and trophoblastic necrosis. This association was not encountered in any of 8857 placentas analyzed during the period between 2002 and 2012 in our institution; (4) Conclusions: The “placentitis triad” appears to be specific for SARS-CoV-2 infection and, in case of massive and acute presentation, could result in poor fetal outcome.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Histopathological “Placentitis Triad” Is Specific for SARS-CoV-2 Infection, and Its Acute Presentation Can Be Associated with Poor Fetal Outcome

Remoué

Suazo

Uguen

et al. 2023

Life

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“…38,39 Current reports suggest that placental abnormalities do not predict fetal SARS-CoV-2 infection. 40,41 An elegant review by Komine-Aizawa et al showed that irrespective of neonatal COVID-19 positivity after birth, placental findings are seen in many pregnant women. Also, fetuses are not necessarily affected despite syncytiotrophoblasts being infected frequently.…”

Section: Outcomes Of Pregnant Mothers With Covid-19mentioning

confidence: 99%

Mother to Newborn Transmission of SARS-CoV-2 Infection: Evolution of Evidence in 1.5 Years of COVID-19 Pandemic

Gupta

Kamity²,

Sharma

et al. 2022

Am J Perinatol

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Coronavirus disease 2019 (COVID-19) pandemic caused significant mortality and morbidity in people of all age groups worldwide. Given the uncertainty regarding the mode of transmission and potential effects of COVID-19 on pregnant mothers and their newborns, guidelines for taking care of maternal–newborn dyads have evolved tremendously since the pandemic began. There has been an enormous influx of published materials regarding the outcomes of mothers and newborns. Still, multiple knowledge gaps regarding comprehensive information about risk to the mothers and newborns exist, which need to be addressed. Current evidence suggests that mothers with symptomatic COVID-19 infection are at increased risk of severe illness during pregnancy, with a higher need for respiratory support and premature deliveries. Neonates born to mothers with COVID-19 are at increased risk of needing intensive care; however, most newborns do well after birth. As new mutant variants arise, we need to be cautious while proactively understanding any new evolving patterns. All leading health authorities strongly recommend COVID-19 vaccination before or during pregnancy to reduce the risk of maternal morbidities and benefit from passing antibodies to newborns prenatally and via breastmilk. Additionally, there are racial, ethnic, and socioeconomic disparities in outcomes and vaccination coverage for pregnant women. This article summarizes the rapidly evolving evidence for the last 1.5 years and aims to help health care professionals care for mothers with COVID-19 and their newborns. Key Points

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“…A few studies have reported adverse neonatal outcomes of COVID-19 infected mothers; however, these associations are still unclear [ 7 , 8 , 12 ]. Currently, limited data with small sample sizes are available regarding the risk of perinatal infection and neonatal outcomes of infants born to COVID-19 infected mothers in Korea [ 1 , 13 , 14 ]. A recent Korean National Mother-Child Cohort study on neonatal outcomes discovered a possible association of COVID-19 mothers with increased NICU admission [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study

Lee,

Jin,

Yoo

et al. 2023

Clin Exp Pediatr

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Background: Limited clinical reports have investigated the effects of maternal coronavirus disease 2019 (COVID-19) on fetuses and neonates.Purpose: This retrospective study aimed to assess the impact of maternal COVID-19 on neonates during the perinatal period, including neonatal clinical outcomes, versus the outcomes of neonates of mothers without COVID-19.Methods: Neonates born to COVID-19-infected mothers at the National Health Insurance Service Ilsan Hospital between February 2021 and March 2022 were included. Those with gestational age (GA) ≥35+0 weeks who were born within 2 weeks of the maternal infection were matched 1:2 with a control group based on GA. The main outcomes were respiratory diseases, including transient tachypnea of the newborn (TTN), respiratory distress syndrome, meconium aspiration syndrome, the need for respiratory support, and length of hospital stay. Uni- and multivariate logistic regression analyses were performed and adjusted for relevant covariates, including maternal age, obstetric complications (hypertension and gestational diabetes), delivery mode, birth weight, sex, and small-for-gestational-age status.Results: The case group comprised 103 neonates (mean GA, 38.5±1.3 weeks; mean birth weight, 3,121±397 g), while the control group included 206 neonates (mean GA, 38.4±1.2 weeks; mean birth weight, 3088±428 g). In the case and control groups, the proportion of cesarean sections was 91% and 40%, respectively, while the proportion of male infants was 56% and 47%, respectively. After adjusting for covariates, the case group had a higher risk of TTN (adjusted odd ratio [AOR], 3.69; 95% confidence interval [CI], 1.69–8.07), noninvasive respiratory ventilator use (AOR, 2.28; 95% CI, 1.05–4.97), and oxygen support (AOR, 4.83; 95% CI, 1.46–15.95).Conclusion: Newborns born to COVID-19-infected mothers are at increased risk of TTN and may require respiratory support. Close monitoring of respiratory symptoms is crucial in neonates.

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Two Cases of SARS-CoV-2-Positive Mothers and Their Newborns in Korea

Cited by 6 publications

References 17 publications

The Histopathological “Placentitis Triad” Is Specific for SARS-CoV-2 Infection, and Its Acute Presentation Can Be Associated with Poor Fetal Outcome

The Histopathological “Placentitis Triad” Is Specific for SARS-CoV-2 Infection, and Its Acute Presentation Can Be Associated with Poor Fetal Outcome

Mother to Newborn Transmission of SARS-CoV-2 Infection: Evolution of Evidence in 1.5 Years of COVID-19 Pandemic

Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study

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