Two Cases of Pulmonary Lymphomatoid Granulomatosis With Different Outcomes

Abstract

Background. Lymphomatoid granulomatosis is a very rare disease, with only 11 cases having been reported in Japan. We report different outcomes in two cases of pulmonary lymphomatoid granulomatosis. Cases. Case 1 involved a 68-year-old woman who had an abnormal pulmonary hilar shadow on chest radiography. Bronchoscopy did not assist diagnosis, so partial resection of the lung was performed under video-assisted thoracic surgery. Frozen section examination suggested lung cancer. Right middle lobectomy with dissection of the mediastinal lymph nodes was performed. Histopathology revealed grade III lymphomatoid granulomatosis. Adjuvant chemotherapy proved ineffective and the patient died 10 months postoperatively. Case 2 involved a 71-year-old woman who also had an abnormal shadow on chest radiography. Bronchoscopy again proved unhelpful, so partial resection of the lung was performed under video-assisted thoracic surgery. Frozen section examination yielded a diagnosis of lymphomatoid granulomatosis, and histopathology confirmed grade I lymphomatoid granulomatosis. The patient remains alive without any sign of recurrence at 1 year postoperatively. Conclusion. We report these 2 cases and review the reports of lymphomatoid