Two Cases of Plasmocytosis Circumorificialis

Kondoh, Akio; Umezawa, Yoshinori; Ohta, Y.; Iizuka, Mana; Matsuyama, Takashi; Ozawa, A.; Yamamoto, Osamu

doi:10.2336/nishinihonhifu.66.485

Cited by 5 publications

(2 citation statements)

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“…Corneodesmosin was described as a secreted glycoprotein incorporated into desmosomes during the first steps of epidermal cornification and potentially important actor in the stratum corneum's cohesion and desquamation (21)(22)(23). Furthermore, desmoyokin is a ubiquitous protein found in desmosomes, whose function in vivo remains a mystery (24). More recently, desmosealin, a new proteoglycan integrated into the desmoglea of desmosomes from the most differentiated epidermal layers, has been described (12,25,26).…”

Section: Discussionmentioning

confidence: 99%

Human epidermal desmosome-enriched tissue fractions for analytical and prospective studies

Sandjeu

Callejon

Vincent

et al. 2011

Experimental Dermatology

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Here, we report a method, adapted to the human epidermis, allowing isolation of desmosomes in small tissue fractions. The methods previously developed for animal skin did not work efficiently with human tissue. Enrichment of desmosomes was performed by the association of two incubation steps in acidic solutions containing detergent NP-40 at two different concentrations followed by a sonication step. The suspension was centrifuged twice: first to remove the heavy cell fragments and then at 16 000 g on a discontinuous sucrose gradient. A desmosome-enriched fraction (DsF) was collected at the 30-50% sucrose interface. We demonstrate by immunoelectron microscopy and by western blotting that the central part of the desmosome structure is preserved as well as the antigenicity of its components. Our approach, allowing a significant enrichment of the cell fractions containing desmosomes, can be used to immunize animals and create new antibodies directed against desmosomal components. Using this strategy, new and so far poorly studied molecules incorporated into the desmosome cores could be targeted more easily.

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Section: Discussionmentioning

confidence: 99%

Human epidermal desmosome-enriched tissue fractions for analytical and prospective studies

Sandjeu

Callejon

Vincent

et al. 2011

Experimental Dermatology

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“…This disease is primarily treated topically with steroids. We recently analyzed 33 cases (17 men and 16 women) of plasmocytosis circumorificialis developing on the lips, reported in Japan between 1983 and 2007 (including the present case), in which adequate information on methods of treatment and outcome were available 5–30 . The outcome of treatment was rated on a three‐category scale: “effective”, “relapsing” or “ineffective”.…”

Section: Discussionmentioning

confidence: 99%

Plasmocytosis circumorificialis successfully treated with topical fusidic acid ointment

Saruya

Fukuda

Saito

et al. 2009

The Journal of Dermatology

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Plasmocytosis circumorificialis is a benign chronic inflammatory disease, which causes erythema, erosions, ulcers, nodules and related changes in and around the openings of the human body, and is histopathologically characterized by dense infiltration of the dermis by plasma cells. We recently encountered a 49-year-old man in whom this disease affected the lower lip. On initial examination in our department, a well-demarcated region of erosion (10 mm x 5 mm), accompanied in part by formation of a crust, was noted on the left side of his lower lip. Histopathologically, the mucosal epithelium exhibited erosions, and dense plasma cell infiltration, without signs of atypia, was noted in the upper through middle layers of the lamina propria. On the basis of these findings, plasmocytosis circumorificialis was diagnosed. Because the patient had experienced repeated cycles of remission and relapse, despite topical treatment with various drugs (e.g. topical antibiotics and steroids), prior to referral to our department, we administered topical 2% fusidate sodium or Fucidin (Leo Pharmaceutical, Ballerup, Denmark) ointment. His eruption healed approximately 3 weeks after the start of this treatment. We report this case and discuss the findings reported in Japan on the development of plasmocytosis circumorificialis of the lips.

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