Abstract:We have experienced two patients with the Brugada-type electrocardiographic abnormalities and incessant wide QRS tachycardia (presumed ventricular tachycardia) induced by intoxication of a class IC antiarrhythmic drug pilsicainide. They were elderly men with impaired renal function. Plasma concentration of pilsicainide was elevated to a toxic level in both patients. After cessation of pilsicainide, incessant wide QRS tachycardia spontaneously subsided and intraventricular conduction delay with coved type ST se… Show more
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