Two Cases of Müllerian Carcinosarcoma

MacFarlane, K. T.; Pritchard, J. E.

doi:10.1016/s0002-9378(16)38251-5

Cited by 22 publications

(10 citation statements)

References 5 publications

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“…[3][4][5][6][7]13 This limited number of recorded examples precludes detailed information as to clinical behavior,The present study is directed primarily toward the clarification of the clinicopathologic F r o m t h e Armed Forces Institute of Pathology, 'Washington, D. C. 20305. features of carcinosarcomas and mixed mesodermal tumors of the ovary. I t is not widely acknowledged, however, that histologically identical tumors also occur in the ovary, as less than 17 welldocumented examples have been reported to date.…”

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confidence: 99%

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Carcinosarcomas and mixed mesodermal tumors of the ovary

Dehner

Norris

Taylor

1971

Cancer

112

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Mixed epithelial and mesenchymal tumors (carcinosarcomas and mixed mesodermal tumors) are well‐recognized entities in the uterus. It is not widely acknowledged, however, that histologically identical tumors also occur in the ovary, as less than 17 well‐documented examples have been reported to date. A clinical and pathologic study of 13 carcinosarcomas and 14 mixed mesodermal tumors of the ovary in the files of this Institute revealed that the clinical profile of patients with either tumor was similar. Typically, women were postmenopausal and nulliparous. An enlarging abdomen with a mass present for about 5 months was the most common mode of presentation. Grossly, the 2 types of tumors were usually indistinguishable, although by definition the mixed mesodermal tumors contained neoplastc heterologous elements (bone, cartilage, and striated muscle) in addition to carcinosarcomatous foci. The major difference between the 2 groups was in survival. The median survival for patients with mixed mesodermal tumors was 6 months, whereas it was 12 months in women with carinosarcoma. These findings agree with the survival difference noted by Norris and Taylor (1966) for the same neoplasm in the uterus. The differential diagnosis of carcinosarcomas and mixed mesodermal tumors is considered, with an emphasis on the differentiation from malignant teratomas (teratocarcinoma).

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“…[3][4][5][6][7]13 This limited number of recorded examples precludes detailed information as to clinical behavior, They differ in that mixed mesodermal tumors contain heterologous elements (bone, cartilage, fat, and striated muscle), while carcinosarcomas do not, and in the uterus mixed mesodermal tumors have a slightly poorer prognosis.…”

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confidence: 99%

Carcinosarcomas and mixed mesodermal tumors of the ovary

Dehner

Norris

Taylor

1971

Cancer

112

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“…There have been several theories to explain the NEYS cell line's histogenesis. MacFarlane and Pritchard suggested endometriosis as the origin 9 . However, very few cases have been demonstrated to arise in endometriosis, and the age of patients with endometriosis is generally much younger than those with carcinosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Establishment and characterization of the NEYS cell line derived from carcinosarcoma of human ovary with special reference to the susceptibility test of anticancer drugs

et al. 2009

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A cell line designated as NEYS was established from ovarian carcinosarcoma (stage IIIc) of a 56-year-old Japanese woman. The extirpated original tumor was carried in growth medium at 0 degrees C to the culture room. The primary culture was done on 20 August 2003. The cell line was composed of angular adhesive cells and showed neoplastic and pleomorphic features, such as bizarre aggregation of chromatin granules, an irregular thickening nuclear membrane and multiple large nucleoli. They grew as multi-layered cultures without contact inhibition. The cells proliferated moderately, and population doubling time was about 56 h. The chromosome number showed an underdiploidy of aneuploidy. The modal chromosome numbers were 37 (36%) and 38 (26%). The cultures produced carcinoembryonic antigen (27.4 ng/mL), carbohydrate antigen 19-9 (210 U/mL), and carbohydrate antigen 125 (526 U/mL). The NEYS cells did not give rise to transplant tumors in nude mice, and showed no susceptibility against cisplatin (CDDP), CPT-11, carboplatin, Paclitaxel, Taxotere and 5-FU. This cell line is useful for studies on the histogenesis of carcinosarcoma and susceptibility of cancer drugs in human ovarian carcinosarcoma. The immunohistochemical and ultrastructual analysis demonstrated that NEYS cells showed epithelial and mesenchymal differentiation, and supported the metaplasis theory as the cause of carcinosarcoma.

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“…endoderm, mesoderm and ectoderm, in con trast to MMT which contains elements of mesodermal layer only. Govan [7], Barwick and Li Volsi [3] and others [14][15][16] have pos tulated a Mullerian derivation of ovarian MMT as for the histogenetic origin of the uterine counterpart. Hernandez et al [8] be lieve that the ovarian MMT should be incor porated into the F1GO histogenetic classifi cation of ovarian sarcomas.…”

Section: Discussionmentioning

confidence: 99%