Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose

Klinke, H.B.; Müller, Irene; Steffenrud, S.; Dahl-Sørensen, Rasmus

doi:10.1016/j.forsciint.2009.11.017

Cited by 39 publications

(18 citation statements)

References 16 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exact mass was entered, and a peak was noticed with a plausible isotopic pattern suggesting the presence of the compound. Later on, a reference standard was attained, and the presence of the compound was verified 15. We are now working on extending the number of basic drugs used in the procedure, with a goal of approximately 400 compounds, which is judged suitable for our demands.…”

Section: Resultsmentioning

confidence: 99%

Toxicological screening of basic drugs in whole blood using UPLC‐TOF‐MS

Dalsgaard

Rasmussen

Müller

et al. 2011

Drug Testing and Analysis

Self Cite

View full text Add to dashboard Cite

Ultra performance liquid chromatography (UPLC) coupled with time-of-flight (TOF) mass spectrometry (MS) was established for toxicological screening of basic drugs in whole blood and tested on authentic samples. Whole blood samples (0.2 ml) were extracted using a Gilson apparatus equipped with Bond Elut Certify columns. Screening was performed for 175 compounds (psychotropic, cardiovascular, designer, and abused drugs). The drugs were separated in 15 min using a UPLC system (Waters ACQUITY BEH C18, 1.7 µm, 2.1 mm × 100 mm column) coupled to an LCT Premier XE (Waters) instrument. Data were processed by ChromaLynx XS using identification criteria of ± 0.2 min retention time, and ± 5 mDa mass tolerance. Whole blood was spiked with the 175 compounds in concentrations from 5-100 µg/kg to assess approximately the lowest concentrations that could be identified. This method was further applied to 119 samples from forensic investigations, leading to 302 hits, of which 291 (96%) were subsequently verified, in concentrations exceeding the lower limit of quantification (LLOQ), by a liquid chromatography (LC)-MS/MS confirmation method. In conclusion, this UPLC-TOF-MS method is a useful and effective screening method for basic drugs in whole blood.

show abstract

Section: Resultsmentioning

confidence: 99%

Toxicological screening of basic drugs in whole blood using UPLC‐TOF‐MS

Dalsgaard

Rasmussen

Müller

et al. 2011

Drug Testing and Analysis

Self Cite

View full text Add to dashboard Cite

show abstract

“…They contain lysergic acid amide (LSA), which is the non-alkylated amide analogue of the schedule I controlled lysergic acid diethyl amide (LSD). [52] As these samples were seeds, before analysis they were ground using an agate mortar and pestle. LSA morning glory seeds were characterised using the black shell and grey content.…”

Section: Plants and Extractsmentioning

confidence: 99%

Identification of new psychoactive substances (NPS) using handheld Raman spectroscopy employing both 785 and 1064 nm laser sources

Guirguis

Girotto

Berti

et al. 2017

Forensic Science International

View full text Add to dashboard Cite

The chemical identification of new psychoactive substances (NPS) in the field is challenging due not only to the plethora of substances available, but also as a result of the chemical complexity of products and the chemical similarity of NPS analogues. In this study, handheld Raman spectroscopy and the use of two excitation wavelengths, 785 and 1064 nm, were evaluated for the identification of 60 NPS products. The products contained a range of NPS from classes including the aminoindanes, arylalkylamines, benzodiazepines, and piperidines & pyrrolidines. Identification was initially assessed using the instruments' in built algorithm (i.e., % HQI) and then further by visual inspection of the Raman spectra. Confirmatory analysis was preformed using gas chromatography mass spectrometry. For the 60 diverse products, an NPS was successfully identified via the algorithm in 11 products (18 %) using the 785 nm source and 29 products (48 %) using the 1064 nm source. Evaluation of the Raman spectra showed that increasing the excitation wavelength from 785 to 1064 nm improved this 'first pass' identification primarily due to a significant reduction in fluorescence, which increased S/N of the characteristic peaks of the substance identified. True positive correlations between internet products and NPS signatures ranged from 57.0 to 91.3 % HQI with typical RSDs < 10 %. Tablet formulations and branded products were particularly challenging as a result of low NPS concentration and high chemical complexity, respectively. This study demonstrates the advantage of using a 1064 nm source with handheld Raman spectroscopy for improved 'first pass' NPS identification when minimal spectral processing is required, such as when working in field. Future investigations will focus on the use of mixture algorithms, effect of NPS concentration, and further improvement of spectral libraries.

show abstract

“…There are only few scientific reports on the human consumption of seeds containing LSA. Side effects are comparable to those observed after ingestion of Argyreia nervosa; some patients can experience hallucination, derealization, memory loss, anxiety, suicidal ideation and also tachycardia, hypertension, pupil dilation, flushing, polyuria, nausea [20].…”

Section: Illegal Plant Species Descriptionmentioning

confidence: 69%

“…Ergine-lysergic acid amide binds to the 5-HT2A receptor (serotonin receptor family) and gives effects similar to LSD (lysergic acid) [13]. Seeds are eaten whole, crushed or consumed as an extract after soaking in water [20]. The main symptoms after ingestion are: visual and auditory hallucinations, anxiety, and euphoria [17,21].…”

Section: Illegal Plant Species Descriptionmentioning

confidence: 99%

Psychoactive plants used in designer drugs as a threat to public health

2015

View full text Add to dashboard Cite

S u m m a r yBased on epidemiologic surveys conducted in [2007][2008][2009][2010][2011][2012][2013], an increase in the consumption of psychoactive substances has been observed. This growth is noticeable in Europe and in Poland. With the 'designer drugs' launch on the market, which ingredients were not placed on the list of controlled substances in the Misuse of Drugs Act, a rise in the number and diversity of psychoactive agents and mixtures was noticed, used to achieve a different state of mind. Thus, the threat to the health and lives of people who use them has grown. In this paper, the authors describe the phenomenon of the use of plant psychoactive substances, paying attention to young people who experiment with new narcotics. This article also discusses the mode of action and side effects of plant materials proscribed under the

show abstract

Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose

Cited by 39 publications

References 16 publications

Toxicological screening of basic drugs in whole blood using UPLC‐TOF‐MS

Toxicological screening of basic drugs in whole blood using UPLC‐TOF‐MS

Identification of new psychoactive substances (NPS) using handheld Raman spectroscopy employing both 785 and 1064 nm laser sources

Psychoactive plants used in designer drugs as a threat to public health

Contact Info

Product

Resources

About