Two Cases of Generalized Pustular Psoriasis: Successful Treatment with Infliximab

Kim, Hoon-Soo; You, Hyang‐Suk; Cho, Hyun-Ho; Kim, Won Jeong; Mun, Je‐Ho; Song, Margaret; Ko, Hyun‐Chang; Kim, Moon‐Bum; Kim, Byung Soo

doi:10.5021/ad.2014.26.6.787

Cited by 15 publications

(23 citation statements)

References 5 publications

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“…However, the safety of TNF-a inhibitors is relatively high compared with conventional therapies. 107 On the other hand, although no RCT have been conducted, the application of infliximab in GPP has been analyzed in case reports, [119][120][121][122][123][124] including a retrospective clinical study of infliximab in GPP conducted in Japan 125,126 and a retrospective case series study of TNF-a inhibitors in acute phase GPP. 18 Because of the cardiovascular complications in some GPP cases, it is important to establish measures against infusion reaction caused by TNF-a inhibitors.…”

Section: Cq15 Are Tnf-a Inhibitors Effective For Gpp?mentioning

confidence: 99%

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Fujita

Terada

Hayama

et al. 2018

The Journal of Dermatology

192

456

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Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and systemic flushing accompanied by extensive sterile pustules. The committee of the guidelines was founded as a collaborative project between the Japanese Dermatological Association and the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labour, and Welfare Research Project on Overcoming Intractable Diseases. The aim of the guidelines was to provide current information to aid in the treatment of patients with GPP in Japan. Its contents include the diagnostic and severity classification criteria for GPP, its pathogenesis, and recommendations for the treatment of GPP. Since there are few clinical trial data with high levels of evidence for this rare disease, recommendations by the committee are described in the present guidelines.

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Section: Cq15 Are Tnf-a Inhibitors Effective For Gpp?mentioning

confidence: 99%

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Fujita

Terada

Hayama

et al. 2018

The Journal of Dermatology

192

456

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“…As a result infliximab having a rapid onset of action, it is considered a first‐line treatment option in patients with severe, acute GPP . Infliximab's efficacy as a maintenance therapy needs to be investigated; secondary failure can occur during the course of treatment …”

Section: Treatmentmentioning

confidence: 99%

Generalized pustular psoriasis: a review and update on treatment

Hoegler

John

Handler

et al. 2018

Acad Dermatol Venereol

150

193

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Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. The interleukin family and caspase recruitment domain family have been implicated in its pathogenesis. Other forms of pustular psoriasis include impetigo herpetiformis, palmoplantar pustular psoriasis, annular pustular psoriasis and acrodermatitis continua of Hallopeau. Treatment is not well established, but includes the use of retinoids, methotrexate, cyclosporine, corticosteroids, TNF-alpha inhibitors, topical therapy and phototherapy. The use of TNF-alpha inhibitors may result in the formation of antidrug antibodies and should be administered with methotrexate.

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“…Znane są opisy przypadków poprawy klinicznej po zastosowaniu u pacjentów z oporną uogólnioną łuszczycą krostkową infliksymabu [6][7][8][9][10], adalimumabu [8,11,12], adalimumabu w połączeniu z metotreksatem [13], adalimumabu z acytretyną [14], etanerceptu [8,15,16], a także ustekinumabu [17]. Potrzebnych jest jednak więcej badań, by potwierdzić te wyniki poprzez obserwację większej grupy pacjentów.…”

Section: Wprowadzenieunclassified

“…In one case report, the patient's condition improved after a single dose of infliximab [7] and in another the desired therapeutic effect was achieved with adalimumab [12]. In another case report after unsuccessful treatment with methotrexate, sulfasalazine and cyclosporine, infliximab was introduced inducing a good clinical response [10].…”

Section: Opis Przypadkumentioning

confidence: 99%

“…W jednym z przypadków poprawa nastąpiła po pojedynczej dawce infliksymabu [7], kolejny opis dotyczy pacjenta, u którego pożądany efekt osiągnięto po zastosowaniu adalimumabu [2]. Opisano również przypadek, w którym po nieskutecznym leczeniu metotreksatem, sulfasalazyną i cyklosporyną wdrożono infliksymab i uzyskano dobrą odpowiedź kliniczną [10].…”

Section: Introductionunclassified

See 1 more Smart Citation

Challenges of biological therapy in patients with pustular psoriasis coexisting with psoriatic arthritis

Trelińska¹,

Woźniacka²,

Olejniczak-Staruch³

et al. 2017

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Two Cases of Generalized Pustular Psoriasis: Successful Treatment with Infliximab

Cited by 15 publications

References 5 publications

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Generalized pustular psoriasis: a review and update on treatment

Challenges of biological therapy in patients with pustular psoriasis coexisting with psoriatic arthritis

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