Two cases of gastric adenocarcinoma with enteroblastic differentiation resected by endoscopic submucosal dissection

Kato, Tsunetaka; Hikichi, Takuto; Nakamura, Jun; Takasumi, Mika; Hashimoto, Minami; Kobashi, Ryoichiro; Takagi, Tadayuki; Suzuki, Rei; Sugimoto, Mitsuru; Sato, Yuki; Okubo, Yoshiro; Satake, Shunsuke; Oka, Yuka; Yamada, Shuhei; Kobayakawa, Masao; Hashimoto, Yuko; Ohira, Hiromasa

doi:10.1007/s12328-021-01356-z

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…In the present case, magnifying endoscopy with narrow-band imaging revealed irregular oval/tubular MS and irregular loop MV patterns. These findings were in line with the histopathological characteristics of GAED, as described in previous reports [8,9]. On immunohistochemical staining, most GAEDs variably express three enteroblastic lineage markers, also known as oncofetal proteins.…”

Section: A B C Dsupporting

confidence: 91%

Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report

Lee,

Kim,

Joo

et al. 2024

Ewha Med J

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We report a rare case of gastric adenocarcinoma with enteroblastic differentiation (GAED) that was treated with endoscopic submucosal dissection followed by additional distal gastrectomy with lymph node dissection. A 67-year-old man underwent endoscopic submucosal dissection for a gastric lesion, which was diagnosed as GAED with submucosal and lymphatic invasion. Histologically, GAED is characterized by a tubulopapillary growth pattern and clear cells that resemble those of the primitive fetal gut. Immunohistochemically, GAED variably expresses oncofetal proteins such as glypican-3, alpha-fetoprotein, and spalt-like transcription factor 4. Despite negative margins, additional gastrectomy with lymph node dissection was performed due to submucosal and lymphatic invasion. No residual tumor or metastasis was detected, and the patient remained disease-free for 2 years before dying from causes unrelated to GAED. Given its aggressive nature, frequent lymphovascular invasion, and high metastatic potential, clinicians should recognize the histopathological diagnosis of this rare tumor and its propensity for aggressiveness.

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Section: A B C Dsupporting

confidence: 91%

Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report

Lee,

Kim,

Joo

et al. 2024

Ewha Med J

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“…This report describes a rare case of GAED in which successful resection was achieved using ESD. Cases of GAED with ESD are rare, and, to our knowledge, this is the 13th case reported in the literature [ 2 , 4 – 7 ]. Compared to other gastric cancers, the preferred site and endoscopic features of GAED are not clear at this time [ 5 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although no AFP measurements were performed prior to ESD in this case, histopathologically typical tumor cells with enteroblastic components and a pale cytoplasm were observed, and AFP was detected via immunostaining. The enteroblastic component in GAED is present in 30–100% of reported cases and has a wide range [ 7 , 8 ]. In this case, approximately 30% of gastric cancer tissues contained an enteroblastic component.…”

Section: Discussionmentioning

confidence: 99%

Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report

Ishikawa,

Nakamura

2024

Case Rep Gastroenterol

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Introduction: Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare histological type of gastric adenocarcinoma that occurs in the stomach and is known for its aggressive behavior. GAED is diagnosed histopathologically and is often advanced at the time of diagnosis. Case Presentation: We report the case of a 70-year-old male with a 20-mm superficial depressed lesion on the anterior wall of the antrum. Histological examination of the endoscopic submucosal dissection specimen revealed that the tumor was composed of dilated or slit-like branching tubules; additionally, the tumor cells had clear cytoplasm resembling that of the fetal digestive tract. Immunohistochemically, the tumor cells were positive for Glypican-3 and alpha-fetoprotein. A pathological diagnosis of GAEDs was established. GAED was found in approximately 30% of all the tumor cells and showed lymphatic invasion. The patient has been under recurrence-free follow-up for approximately 1 year after the endoscopic submucosal dissection. Conclusion: In order to detect a large number of cases, immunostaining should be aggressively performed if morphological findings are suspicious for GAED.

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“…There are case reports of GAEDs treated with endoscopic submucosal dissection (ESD) in Japan. 14,15 In these cases, there Fig. 5.…”

Section: A B C Dmentioning

confidence: 96%

Gastric Cancer Showing Rapid Recurrence and Progression: A Case of Gastric Adenocarcinoma With Enteroblastic Differentiation

Choi

2024

Korean J Helicobacter Up Gastrointest Res

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Gastric adenocarcinoma with enteroblastic differentiation (GAED) is rare and its clinicopathological characteristics are not well documented. However, reports indicate that it exhibits more aggressive characteristics, including lymph node metastasis or liver metastasis, than a conventional gastric adenocarcinoma. Herein, we report a case of GAED with rapid recurrence and disease progression. A 55-year-old male, diagnosed with gastric cancer (GC), demonstrated initial endoscopic findings suggestive of advanced GC. He underwent curative resection since there was no evidence of lymph node or distant metastases. The disease was reported as an early GC that was confined to the submucosal layer, without evidence of lymph node metastasis in the final pathological results. However, six months after surgery, multiple hepatic metastases were found during abdominal computed tomography; the pathological results were consistent with metastasis from the GC. Immunohistochemistry of the primary carcinoma pathological specimens showed positive results for alpha-fetoprotein and sal-like protein 4, suggesting enteroblastic differentiation, which is thought to be associated with rapid recurrence and disease progression.

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Two cases of gastric adenocarcinoma with enteroblastic differentiation resected by endoscopic submucosal dissection

Cited by 7 publications

References 12 publications

Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report

Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report

Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report

Gastric Cancer Showing Rapid Recurrence and Progression: A Case of Gastric Adenocarcinoma With Enteroblastic Differentiation

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