Two cases of Fusarium keratomycosis in the horse

Dr, Hodgson; Ka, Jacobs

doi:10.1136/vr.110.22.520

Cited by 18 publications

(8 citation statements)

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“…Many early cases of equine fungal keratitis present, initially, as minor corneal epithelial ulcers or infiltrates with pain, blepharospasm, epiphora and photophobia (Mitchell and Attleberger 1973;Hodgson and Jacobs 1982). At first anterior uveitis and corneal neovascularisation may not be clinically evident.…”

Section: Clinical History and Appearancementioning

confidence: 99%

Equine keratomycosis: Current concepts of diagnosis and therapy

Kern

Brooks

White

1983

Equine Veterinary Journal

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Section: Clinical History and Appearancementioning

confidence: 99%

Equine keratomycosis: Current concepts of diagnosis and therapy

Kern

Brooks

White

1983

Equine Veterinary Journal

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“…As part of the treatment protocol for equine corneal ulceration, anticollagenase therapy is sometimes indicated to prevent corneal rupture 3,5 . Some of the agents reported to have anticollagenase activity include: acetylcysteine, sodium edenate, disodium, calcium ethylenediaminetetraacetic acid (EDTA), cysteine, penicillamine, tetracyclines, synthetic thiol peptides, collagen shields, dilute iodine, heparin, plasma, serum, equine tetanus antitoxin, doxycycline and methylprednisolone 3–12 …”

Section: Introductionmentioning

confidence: 99%

“…Instillation and subconjunctival injection of equine serum and tetanus antitoxin are clinically employed as anticollagenolytic treatments for equine corneal ulcers 6,13 . The alpha‐2‐macroglobulin portion of human serum has been shown to inhibit the action of human and rabbit corneal collagenase by the formation of tight complexes between the alpha‐2‐macroglobulin and the enzyme 2,14 .…”

Section: Introductionmentioning

confidence: 99%

“…3,5 Some of the agents reported to have anticollagenase activity include: acetylcysteine, sodium edenate, disodium, calcium ethylenediaminetetraacetic acid (EDTA), cysteine, penicillamine, tetracyclines, synthetic thiol peptides, collagen shields, dilute iodine, heparin, plasma, serum, equine tetanus antitoxin, doxycycline and methylprednisolone. [3][4][5][6][7][8][9][10][11][12] Instillation and subconjunctival injection of equine serum and tetanus antitoxin are clinically employed as anticollagenolytic treatments for equine corneal ulcers. 6,13 The alpha-2-macroglobulin portion of human serum has been shown to inhibit the action of human and rabbit corneal collagenase by the formation of tight complexes between the alpha-2-macroglobulin and the enzyme.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12] Instillation and subconjunctival injection of equine serum and tetanus antitoxin are clinically employed as anticollagenolytic treatments for equine corneal ulcers. 6,13 The alpha-2-macroglobulin portion of human serum has been shown to inhibit the action of human and rabbit corneal collagenase by the formation of tight complexes between the alpha-2-macroglobulin and the enzyme. 2,14 However, the anticollagenase activity of equine serum, tetanus antitoxin and acetylcysteine on equine corneas (either in horses or in laboratory conditions) has not been documented.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of collagenase breakdown of equine corneas by tetanus antitoxin, equine serum and acetylcysteine

Haffner¹,

Fecteau

Eiler

2003

Veterinary Ophthalmology

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Objective To determine whether tetanus antitoxin, equine serum, and acetylcysteine, which are currently used in the treatment of equine corneal ulcer, inhibit the digestion of equine corneal collagen when exposed to collagenase in vitro. Animals studied Corneas from 40 adult horses. Procedures Sections of equine corneas were incubated with saline, a solution of bacterial collagenase in saline, bacterial collagenase in saline plus equine tetanus antitoxin, bacterial collagenase in saline plus equine serum, or bacterial collagenase in saline plus acetylcysteine. Each one of the collagenase inhibitors was tested at different concentrations. The degree of corneal collagen digestion was determined by concentrations of hydroxyproline released into the incubation media and/or by weight loss of the cornea. Results Corneas exposed to collagenase released a significant (0.05 level) large amount of hydroxyproline (43.1 ± 2.3 µg/mL/100 mg cornea/5 h) and decreased cornea weight by up to 89%. Blood serum (200 µL/mL), purified albumin or globulin fractions of serum, tetanus antitoxin (120 units/mL), and acetylcysteine (20 mg/mL) when used at the highest concentrations blocked collagenase digestive activity by approximately 50%. Dilution of inhibitors decreased corneal protection and linearly increased corneal weight loss. Purified equine serum albumin and globulin fractions were equally effective in protecting corneas. Conclusions This experiment indicates that tetanus antitoxin, serum and acetylcysteine equally protected corneas from collagenase digestion, in vitro. However, a clinical trial is needed to establish relative therapeutic value.

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Drug Permeation Through the Skin and Topical Preparations

Baggot¹

2001

The Physiological Basis of Veterinary Clinical Pharmacology

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Two cases of Fusarium keratomycosis in the horse

Cited by 18 publications

References 0 publications

Equine keratomycosis: Current concepts of diagnosis and therapy

Equine keratomycosis: Current concepts of diagnosis and therapy

Inhibition of collagenase breakdown of equine corneas by tetanus antitoxin, equine serum and acetylcysteine

Drug Permeation Through the Skin and Topical Preparations

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