Two cases of fungal keratitis caused by Metarhizium anisopliae

Goodman, Abigail; Lockhart, Shawn R.; Lysen, Colleen; Westblade, Lars F.; Burd, Eileen M.

doi:10.1016/j.mmcr.2018.03.003

Cited by 6 publications

(3 citation statements)

References 17 publications

(38 reference statements)

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“…There have been few reports of ocular infections secondary to the M. anisopliae complex, 2,6 and only 3 reports of Metarhizium keratitis specifically identify M. robertsii as the causative agent. 7 All of the reported cases of M. anisopliae complex ocular infection were in immunocompetent individuals, as in our patient.…”

Section: Discussionmentioning

confidence: 99%

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Palazzolo

Kowalski

Nayyar

et al. 2021

Cornea

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This study aimed to describe a case of keratitis secondary to Metarhizium robertsii, a soil-dwelling fungus with typical insect pathogenicity.Methods: A Case report.Results: A 58-year-old man with a ocular history of soft contact lens overwear, poor contact lens hygiene, and ocular exposure to ground well water supplying his house was referred to our university practice for a central corneal ulcer with 40% thinning. Same-day rapid microscopic detection with Giemsa stain identified the presence of many hyphae elements, and he was ultimately diagnosed with M. robertsii keratitis. The patient's course involved severe and progressive corneal thinning that stabilized over a 3-month course of antifungal therapy.Conclusions: Metarhizium robertsii seems more aggressive than other forms of fungal keratitis; therefore, this infection may be watched more closely with the risk for quick progressive corneal thinning, even while on antifungal management.

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Section: Discussionmentioning

confidence: 99%

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Palazzolo

Kowalski

Nayyar

et al. 2021

Cornea

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“…Notably, it is difficult to culture and mass produce fungi ( Accoti et al, 2021 ). More importantly, these entomopathogenic fungi have been reported to cause symptomatic infections in immuno-compromised humans, raising safety concerns regarding this vector biocontrol agent ( Henke et al, 2002 ; Tucker et al, 2004 ; Lara Oya et al, 2016 ; Goodman et al, 2018 ). These drawbacks render fungi a less attractive vector biocontrol option.…”

Section: Pathogenesis-mediated Vector Biocontrolmentioning

confidence: 99%

Perspectives of vector management in the control and elimination of vector-borne zoonoses

Wong

Zulzahrin²,

Vythilingam³

et al. 2023

Front. Microbiol.

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The complex transmission profiles of vector-borne zoonoses (VZB) and vector-borne infections with animal reservoirs (VBIAR) complicate efforts to break the transmission circuit of these infections. To control and eliminate VZB and VBIAR, insecticide application may not be conducted easily in all circumstances, particularly for infections with sylvatic transmission cycle. As a result, alternative approaches have been considered in the vector management against these infections. In this review, we highlighted differences among the environmental, chemical, and biological control approaches in vector management, from the perspectives of VZB and VBIAR. Concerns and knowledge gaps pertaining to the available control approaches were discussed to better understand the prospects of integrating these vector control approaches to synergistically break the transmission of VZB and VBIAR in humans, in line with the integrated vector management (IVM) developed by the World Health Organization (WHO) since 2004.

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“…A potential zoonotic activity of EPFs has been reported. M. robertsii, M. guizhouense, M. brunneum and M. pingshaense (specie complex M. anisopliae) were referred as the species involved with human infection, mostly keratitis [305], although two cases of keratitis due to M. anisopliae have been reported in soft contact lens wearers [306]. However, considering a last further recent taxonomic study, comprising the description on new species [20], within the known complexes, it is very hard to state the lack of zoonotic ability of Metarhizium species, used as mycoacaricide.…”

Section: Zoonotic Potential Of Epfsmentioning

confidence: 99%

Entomopathogenic Fungi and Bacteria in a Veterinary Perspective

Ebani

Mancianti

2021

Biology

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The present study aimed to review the papers dealing with the biological activity of fungi and bacteria against some mites and ticks of veterinary interest. In particular, the attention was turned to the research regarding acarid species, Dermanyssus gallinae and Psoroptes sp., which are the cause of severe threat in farm animals and, regarding ticks, also pets. Their impact on animal and human health has been stressed, examining the weaknesses and strengths of conventional treatments. Bacillus thuringiensis, Beauveria bassiana and Metarhizium anisopliae are the most widely employed agents. Their activities have been reviewed, considering the feasibility of an in-field application and the effectiveness of the administration alone or combined with conventional and alternative drugs is reported.

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Two cases of fungal keratitis caused by Metarhizium anisopliae

Cited by 6 publications

References 17 publications

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Perspectives of vector management in the control and elimination of vector-borne zoonoses

Entomopathogenic Fungi and Bacteria in a Veterinary Perspective

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