Two cases of fulminant hepatitis E occurred in Hakodate area 2010, suggesting infection with single source hepatitis E virus separated from small epidemic in Sapporo 2009

Acute liver failure caused by hepatitis E virus genotype 3 and 4: A systematic review and pooled analysis

“…Thirty‐five studies from 9 countries published between 1992 and 2017 met the selection criteria . We identified 12 studies through the librarian search, 12 studies through the Google Scholar database, and 11 studies through manual search of reference .…”

“…The median interval between onset of symptoms and death was 51 days (data available for 21 of 27 patients who died). Post‐mortem exam was performed in 1 patient and revealed liver atrophy with massive hepato‐cellular necrosis …”

“…through the librarian search, 12 studies through the Google Scholar database, 3,16,22,29,31,34,35,[40][41][42][43][44] and 11 studies through manual search of reference. 14,15,[17][18][19][20][21][26][27][28]46 The publication language was Spanish in 1 study, 24 French in 1 study, 16 Japanese in 4 studies, 22,27,32,37 and English in the remaining studies. One publication was in an abstract form, 14 6 publications were reported as letters to the editor, 16,17,21,22,43,44 and all the remaining studies were full text articles.…”