Two cases of food additive-induced severe liver damage associated with positive results on lymphocyte stimulation test and for antinuclear antibodies

Kaneko, Rena; Ohishi, Chitose; Kim, Miniru; Shiina, Masaaki; Kusayanagi, Satoshi; Ogawa, Masazumi; Munakata, Kazuo; Mizuno, Kyoichi; Sato, Yuzuru

doi:10.1007/s12328-012-0312-7

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…There is ample evidence in the literature confirming the effect many of over-the-counter (OTC) drugs, dietary supplements (juices, various herbal preparations) and other preanalytical factors on laboratory test results [1][2][3][4]. These effects are exerted through direct (e.g.…”

Section: Introductionmentioning

confidence: 99%

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Šimundić¹,

Filipi

Vrtarić

et al. 2018

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background Nowadays over-the-counter (OTC) drugs and dietary supplements are widely used. Their use can have a significant impact on the validity of laboratory results. The aim of this multicenter European study was to determine the frequency of consumption of various dietary products and OTC drugs among patients and explore their level of knowledge and awareness about the potential impact of various products on laboratory test results. Methods Eighteen European countries participated in this study. The survey was carried out anonymously on a subsequent series of outpatients (n=200) in each participating country. Included were patients who were referred to the laboratory for blood sampling and who voluntarily agreed to participate in the study. The survey included questions about the frequency of consumption of various products, awareness of the importance of informing physicians and laboratory staff about it and information about influence of preanalytical factors in general on laboratory test results. Results In total, 68% of patients were regularly taking at least one OTC drug or dietary supplement. The frequency of patients consuming at least one OTC drug or dietary supplement differed between countries (p=0.001). Vitamins (38%), minerals (34%), cranberry juice (20%), acetylsalicylic acid (ASA) (17%) and omega fatty acids (17%) were the most commonly used in our study. Conclusions The use of various OTC drugs and dietary supplements is highly prevalent in Europe and patients are often not willing to disclose this information to the laboratory staff and ordering physician. The education of both patients and healthcare staff is needed.

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Section: Introductionmentioning

confidence: 99%

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Šimundić¹,

Filipi

Vrtarić

et al. 2018

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…DILI is often responsible for boxed warnings, drug nonapproval or drug withdrawal, even in acute liver failure (ALF) (20). Many drugs cause hepatotoxicity, including over-the-counter (OTC) drugs (21), herbs and dietary supplements (22)(23)(24). The symptoms of DILI range from mildly elevated liver enzymes to severe hepatic damage like ALF.…”

Section: Discussionmentioning

confidence: 99%

Adaptive unfolded protein response promotes cell survival in rifampicin-treated L02 cells

Zhang

2018

Int J Mol Med

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An important concept in drug-induced liver injury (DILI) is adaptation, which means the injury reverses with the continuation of the drug. The mechanism of adaption of drugs remains enigmatic, adaptive unfolded protein response (UPR) is possibly involved. We once observed adaptation phenomenon of rifampicin (RFP) in animal models, in this study, we investigate the effects of RFP on adaptive UPR in L02 cells, and after inhibiting UPR by using 4-phenylbutyrate (4-PBA), the change of cell viability and cell apoptosis in RFP-treated cells. We found that with the concentration of RFP increased and the treatment time was prolonged, the glucose-regulated protein 78 (GRP78), a hallmark of the UPR, was upregulated, and was dose- and time-dependent. RFP also activates the p-eukaryotic initiation factor 2α (eIF2α) protein expression. 4-PBA decreased GRP78 and p-eIF2α protein expression levels. Moreover, FCA showed that cell apoptosis rate obviously increased, and MTT assay showed that cell survival rate obviously decreased, this indicates that after inhibiting the UPR, the cell damage increased, which shows that the UPR is an adaptation mechanism to protect cells against injury induced by RFP. This also proves that when the degree of UPR induced by RFP is relatively mild, adaptive UPR is helpful for cell survival.

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“…Generally, the liver, which acts as an immune tolerant organ, is tolerant to food antigens. However, prolonged exposure to antigens leads to the imbalance of the gut–liver axis, which in turn activates the liver immune response and ultimately causes liver damage [ 7 , 8 , 9 ]. Oxidative stress plays an indispensable part in food allergy-induced liver damage accompanied by the reduction in SOD activity, dropped GSH level, and the increasing levels of malondialdehyde (MDA) and nitric oxide (NO) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Rosmarinic Acid on Ovalbumin-Induced Intestinal Food Allergy Mouse Model

et al. 2023

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Rosmarinic acid (RA) has been proven to exert antianaphylaxis in atopic dermatitis, asthma, and allergic rhinitis. The aim of this study was to determine the hepatoprotective effects of RA on ovalbumin (OVA) challenge-induced intestinal allergy. The results exhibited that RA could relieve anaphylactic symptoms, decrease diarrhea, and prevent hypothermia in allergic mice. Moreover, the elevation of OVA specific IgE (OVA-sIgE), histamine, and mouse mast cell proteinases (mMCP-1) in the serum of OVA challenged mice were remarkably inhibited by RA. OVA challenge resulted in notable increases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, liver malondialdehyde (MDA) and nitic oxide (NO) levels, and a remarkable decrease in liver superoxide dismutase (SOD) activity and glutathione (GSH) level. RA treatments succeeded in improving these biochemical parameters and promote the redox homeostasis. Cytokine expression evaluation showed that RA effectively enhanced the expression of anti-inflammatory cytokines (IL-10 and FOXP-3) in the liver of OVA-challenged mice. Meanwhile, the elevation of pro-inflammatory cytokines (TNF-α, IL-4, IL-6, mMCP-1, and iNOS) were remarkably inhibited by RA. These findings suggest that RA possesses hepatoprotective effects on OVA challenge-induced liver injury. The anti-oxidative and anti-inflammatory activities of RA potentially play vital roles in this process.

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Two cases of food additive-induced severe liver damage associated with positive results on lymphocyte stimulation test and for antinuclear antibodies

Cited by 6 publications

References 18 publications

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Adaptive unfolded protein response promotes cell survival in rifampicin-treated L02 cells

Hepatoprotective Effects of Rosmarinic Acid on Ovalbumin-Induced Intestinal Food Allergy Mouse Model

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