Two cases of folliculosebaceous cystic hamartoma.

Abstract

Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma composed of dilated folliculosebaceous units associated with mesenchymal elements. Two cases of FSCH with typical histopathological features are reported. Patient 1 was a 60-year-old man presented with a normal skin-coloured asymptomatic nodule on his scalp. Patient 2 was a 70-year-old man with an asymptomatic nodule on his right auricle that had persisted for the previous 15 years. In all, 34 cases of FSCH have been reported in the English literature. Clinically, the lesions are asymptomatic, usually rubbery to firm in consistency, and usually occur on or above the neck (> 90%). Most lesions do not exceed 25 mm in diameter (> 90%). Histopathologically, FSCH shares several similar features to sebaceous trichofolliculoma, but it is usually possible to differentiate these two tumours.

Folliculosebaceous smooth muscle hamartoma

“…1,2 A thorough review of the literature revealed a total of 29 cases of primary FSCH arising in 28 patients. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] These cases are summarized in Table I. Two cases of secondary FSCH, one arising in a giant nevus lipomatous superficialis 15 and another arising in a port-wine stain, 16 were excluded from the table.…”

Folliculosebaceous Cystic Hamartoma in a Patient with Neurofibromatosis Type I

“…Although some cases of giant FSCH have been reported, the vast majority of lesions are 0.5 to 1.5 cm-sized papules or nodules9. Due to its lack of distinctive clinical features, they are often misdiagnosed as other disorders such as intradermal nevus, sebaceous hyperplasia, lipoma and neurofibroma10,11. The differential diagnosis includes STF, steatocystoma and dermoid cyst.…”

Neuro-folliculo-sebaceous cystic hamartoma is a unique entity

“…It always presents as a painless, slowly growing single firm papule or nodule with a predilection for the central face [3,4]. Other parts such as the vulva, the nipple, the scrotum, the ear or scalp have been reported for FSCH [5,9].…”

“…Folliculosebaceous cystic hamartoma was first described by Kimura et al [1] in 1991 as a rare cutaneous hamartoma composed mainly of follicular, sebaceous and mesenchymal elements [1,2]. Folliculosebaceous cystic hamartoma does not have peculiar clinical features [3,4]. Clinicians always suggest cyst-like cutaneous lesion, soft tissue neoplasm, sebaceous gland hyperplasia or melanocytic nevus [3,4].…”

“…Folliculosebaceous cystic hamartoma does not have peculiar clinical features [3,4]. Clinicians always suggest cyst-like cutaneous lesion, soft tissue neoplasm, sebaceous gland hyperplasia or melanocytic nevus [3,4].…”