Two cases of female urethral reconstruction with acellular porcine urinary bladder matrix

Ansari, Sana; Karram, Mickey M.

doi:10.1007/s00192-016-3262-7

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…These include mesothelial cell-seeded autogenous granulation tissue tube and cell-based tissue engineering approach [23,24]. Ansari and Karram reported female urethral reconstruction for complete urethral loss using acellular porcine urinary bladder matrix with successful clinical outcomes [25]. Majority of the patients had successful fistula repair; more than half of the women had successful closure of fistula and urinary continence.…”

Section: Discussionmentioning

confidence: 99%

Outcome of urethral reconstruction among vesico-vaginal fistula patients: a cross-sectional study

et al. 2021

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Background Obstetric fistula (OF) complicated by urethral loss (UL) poses a challenge to both the fistula surgeon and obstetric fistula patient. The involvement of the urethra and urethral closure mechanism in OF is an important determinant of successful closure of fistula and restoration of urinary continence. OF with UL is often associated with unsuccessful repair outcome. We describe urethral reconstruction in genital tract fistula patients with UL and the outcomes of the repair. Methods Aim To review the clinical characteristics and outcome of vesico-vaginal fistula associated urethral loss following urethral reconstruction. This was a descriptive cross-sectional study conducted at the University College Hospital, Ibadan, Nigeria. A 5-year prospective data of all vesico-vaginal fistula patients with urethral loss (2011–2016) were reviewed and analysed. Data collected include socio-demographic and obstetric characteristics; cause of the fistula; and fistula characteristics—type of fistula, number of previous repairs, urethral loss, outcome of repair and follow-up. Data were entered and analysed using IBM SPSS version 20. Results Urethral loss occurred in 23 (15.3%) out of 150 women with OF; these women had urethral reconstruction surgery. The commonest type of urethral loss encountered in this cohort was proximal urethral loss which was seen in 12 (52.2%) patients. The most common types of fistula seen with urethral loss were large vesico-vaginal fistula (34.8%) and mid-vaginal fistula (26.1%). More than half of the women (56.6%) had previous unsuccessful repair at other facilities before presentation. The fistula closure rate was high (82.6%) regardless of type of urethral loss. Among the women with successful closure of OF with UL, about 36.8% had urinary stress incontinence post-fistula repair. Conclusion Urethral loss appears to be a rare complication of obstetric fistula. Successful closure with stress incontinence was seen in a sizeable number of women with OF with UL. Preoperative assessment for determinant of post-repair incontinence and surgical repair by experienced surgeons will improve successful outcome of repair in women with obstetric fistula with UL.

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Section: Discussionmentioning

confidence: 99%

Outcome of urethral reconstruction among vesico-vaginal fistula patients: a cross-sectional study

et al. 2021

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“…In one case, dECM sheets were used in conjunction with a stent to repair recurrent anastomotic strictures following a repair of a congenital long-gap oesophageal atresia, and, after two treatments, there was successful growth of new mucosal tissue, with minimal inflammation and no recurrence of the stricture after stent removal [ 364 ]. In two separate cases where dECM was used to repair damaged urethras, the grafts appeared to form natural urethral mucosa [ 365 ]. Kesavan R et al (2021) used minimally manipulated dECM from autologous homologous adipose tissue to 3D print a wound patch, and all of the patients in the treatment group showed complete wound closure and epithelization within four weeks, whereas patients in the control group who received the standard wound care showed delayed wound healing (~50% at 12 weeks) [ 366 ].…”

Section: Applications Of Decmmentioning

confidence: 99%

Preparation and Use of Decellularized Extracellular Matrix for Tissue Engineering

McInnes

Möser

Chen

2022

JFB

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The multidisciplinary fields of tissue engineering and regenerative medicine have the potential to revolutionize the practise of medicine through the abilities to repair, regenerate, or replace tissues and organs with functional engineered constructs. To this end, tissue engineering combines scaffolding materials with cells and biologically active molecules into constructs with the appropriate structures and properties for tissue/organ regeneration, where scaffolding materials and biomolecules are the keys to mimic the native extracellular matrix (ECM). For this, one emerging way is to decellularize the native ECM into the materials suitable for, directly or in combination with other materials, creating functional constructs. Over the past decade, decellularized ECM (or dECM) has greatly facilitated the advance of tissue engineering and regenerative medicine, while being challenged in many ways. This article reviews the recent development of dECM for tissue engineering and regenerative medicine, with a focus on the preparation of dECM along with its influence on cell culture, the modification of dECM for use as a scaffolding material, and the novel techniques and emerging trends in processing dECM into functional constructs. We highlight the success of dECM and constructs in the in vitro, in vivo, and clinical applications and further identify the key issues and challenges involved, along with a discussion of future research directions.

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“…Short term follow-up revealed recurrence of SUI in 1 patient. 69 While some success has been shown with male urethroplasty utilizing TE, it is evident that more work must be done to explore the advantages and role of TE in female urethral reconstruction when compared to autologous grafting techniques.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Treatment of Urethral Stricture Disease in Women: Nonsystematic Review of Surgical Techniques and Intraoperative Considerations

Chua¹,

Mikhail²,

Patel³

et al. 2021

RRU

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Female urethral strictures are rare, but underdiagnosed pathologies that can cause voiding dysfunction. These strictures are best managed with open reconstruction, as endoscopic treatments have high rates of failure. A flap urethroplasty can be performed with vaginal, labial or bladder tissue. Meanwhile, graft urethroplasties can utilize vaginal, labial, buccal or lingual tissue. It is important to consider the etiology and type of stricture, local vascularity, and prior attempts at repair when selecting the type of repair. Multiple different techniques have been described with theoretical advantages to each one. While some studies have reviewed a few of the reconstructive techniques to treat female urethral strictures, no single study has accounted for each individual technique. In this review, we discuss techniques captured by a number of systematic reviews and other articles. We will herein focus on reviewing and describing each unique technique of reconstruction in the setting of female urethral stricture.

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Two cases of female urethral reconstruction with acellular porcine urinary bladder matrix

Cited by 7 publications

References 11 publications

Outcome of urethral reconstruction among vesico-vaginal fistula patients: a cross-sectional study

Outcome of urethral reconstruction among vesico-vaginal fistula patients: a cross-sectional study

Preparation and Use of Decellularized Extracellular Matrix for Tissue Engineering

Treatment of Urethral Stricture Disease in Women: Nonsystematic Review of Surgical Techniques and Intraoperative Considerations

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