Two Cases of Eosinophilic Variant Chromophobe Renal Cell Carcinoma, with a Rare Association of Right Atrial Myxoma in One of them

Abstract

Chromophobe renal cell carcinoma is a relatively uncommon variant of renal cell carcinoma. Eosinophilic variant of chromophobe renal cell carcinoma (EVCRCC) is still less frequent and is composed predominantly of small to medium-sized cells with abundant granular eosinophilic cytoplasm. We report two cases of EVCRCC, with one having a rare association of right atrial myxoma. We present these cases, due to the rarity of EVCRCC and an unusual association of right atrial myxoma in one of them. Both patients recovered well after surgery, with no recurrence or metastasis after 2 years of follow-up.

Eosinophilic Variant of Chromophobe Renal Cell Carcinoma

“…Immunohistochemically, EVCRCC is reactive for CK7 and negative for vimentin. Additionally, Hale's colloidal iron stain shows diff use reticular cytoplasmic positivity in EVCRCC, whereas oncocytomas display focal positive staining confi ned to the luminal borders (8). Ultrastructurally, the cells of an oncocytoma are packed with mitochondria, whereas the cells in EVCRCC have numerous microvesicles in the cytoplasm (8).…”