Two cases of eosinophilic pustular folliculitis associated with pregnancy

Matsudate, Yoshihiro; Miyaoka, Yuki; Urano, Yoshio

doi:10.1111/1346-8138.13179

Cited by 4 publications

(2 citation statements)

References 5 publications

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“… 1 And EPFs presenting with other diseases have been reported, such as EPF associated with cutaneous angiosarcoma, EPF associated with pregnancy and EPF associated with herpes zoster. 2–4 While the pathogenesis of EPF remains uncertain, various studies indicate that Th2-mediated immunologic mechanisms and prostaglandin D2 (PGD2) are involved in the pathogenesis of EPF. Th2 cytokines, such as IL-4, IL-5 and IL-13, promote the production of eosinophil chemokines via the component cells of the skin (such as lymphocytes).…”

Section: Discussionmentioning

confidence: 99%

Classic Eosinophilic Pustular Folliculitis in an Immunocompetent Patient with Syphilis: Are They Related?

Nie

Cao

et al. 2023

CCID

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Eosinophilic pustular folliculitis (EPF) is a rare, chronic, non-infectious inflammatory skin disease. Although the pathogenesis of EPF is unknown, eosinophilic pustular folliculitis may be associated with human immunodeficiency virus (HIV) infection, malignancies or syphilis. Here, we report the first case of EPF associated with syphilis, indicating that syphilis and EPF are correlated with T-helper type 2 immune responses. A 48-year-old man gradually developed erythema and pustules on the face, neck. Physical examination revealed multiple infiltrative red patches and plaques on the face, neck with tiny pustules. Skin biopsy results revealed that the dermal follicular sebaceous gland unit was infiltrated by a large number of neutrophils and eosinophils, forming eosinophilic microabscesses. Therefore, the patient was diagnosed with EPF associated with syphilis and received drug treatment. After the treatment, the pustules markedly decreased, leaving behind pigmentation. Furthermore, the patient is still being followed up.

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Section: Discussionmentioning

confidence: 99%

Classic Eosinophilic Pustular Folliculitis in an Immunocompetent Patient with Syphilis: Are They Related?

Nie

Cao

et al. 2023

CCID

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“…A few other cases not belonging to these types of EPF have been reported, including EPF associated with cutaneous angiosarcoma and EPF associated with pregnancy. 3,4 Matsudate et al 3 reported 8 cases of EPF-associated pregnancies, including a case of EPF that resolved after delivery but exacerbated in the next pregnancy. These cases developed before the start of pregnancy and exacerbated during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

A Case of Eosinophilic Pustular Folliculitis Associated With Herpes Zoster

Lee

Kim

et al. 2020

The American Journal of Dermatopathology

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Patients with eosinophilic pustular folliculitis (EPF), a sterile eosinophilic infiltration of hair follicles, often present with papulopustules that tend to form annular plaques. Histopathologic examination revealed eosinophilic infiltration around the pilosebaceous units and eosinophilic microabscess formation. Although the pathogenesis of EPF is unknown, T-helper type 2 immune responses were suggested to be important based on their stimulating effect on the sebaceous glands. Here, we report the first case of EPF associated with herpes zoster, indicating that herpes zoster and EPF are correlated with T-helper type 2 immune responses.

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