Two cases of disseminated tuberculosis after negative screening before adalimumab treatment for immune-mediated inflammatory diseases

Almeida, Rita Fernanda Cortez de; Penha, Ricardo Cortez Cardoso; Barbosa, Lívia do Nascimento

doi:10.1016/j.jdcr.2019.09.008

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…IFN-c release assays are the current standard, but there is controversial evidence regarding their utility, 28,29 and improved testing is needed to minimize the risk of reactivated or disseminated disease. [30][31][32] When managing patients with a previous history of treated tuberculosis, it is essential to obtain documentation of completed therapy. Due to their previous exposure, both IGRA and TST results will be positive, making it necessary to monitor them through chest radiographs and clinical symptom assessment.…”

Section: Tb and Biologicsmentioning

confidence: 99%

“…These medications can compromise the immune system and activate latent tuberculosis infections. IFN‐γ release assays are the current standard, but there is controversial evidence regarding their utility, 28,29 and improved testing is needed to minimize the risk of reactivated or disseminated disease 30–32 . When managing patients with a previous history of treated tuberculosis, it is essential to obtain documentation of completed therapy.…”

Section: Diagnostics and Screeningmentioning

confidence: 99%

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Dermatology practice updates in mycobacterial disease

Barker,

Alshaikh,

Elston

2023

Int J Dermatology

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Atypical mycobacterial infections are commonly acquired through exposure to water, and tuberculosis remains highly endemic in many parts of the world. In this era of global connection, travel, and immigration, it is more important than ever to maintain a high index of suspicion for infection from cutaneous tuberculosis and atypical mycobacteria. Epidemics related to surgical procedures have been related to inadequate sterilization, as almost 50% of public water supplies harbor mycobacteria. Improved diagnostic techniques for these microbes, including Auramine–Rhodamine staining and rapid detection of mycobacteria and drug susceptibilities through PCR and MALDI‐TOF, have improved detection and treatment outcomes. Given an increasing number of patients on immunosuppressive therapies, clinicians must remain vigilant.

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Section: Tb and Biologicsmentioning

confidence: 99%

Section: Diagnostics and Screeningmentioning

confidence: 99%

Dermatology practice updates in mycobacterial disease

Barker,

Alshaikh,

Elston

2023

Int J Dermatology

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Long-term safety of adalimumab for patients with moderate-to-severe hidradenitis suppurativa

Tzanetakou

Stergianou

Giamarellos‐Bourboulis

2020

Expert Opinion on Drug Safety

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Immunological skin tests in differential diagnostics disseminated processes in the lungs

Стогова

2020

Pulʹmonologiâ (Mosk.)

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Diseases that manifest as Х-ray syndrome of pulmonary dissemination are one of the most complex differential diagnostic problems in pulmonology and Phthisiology. Literature data on the effectiveness of using a new intradermal test with tuberculosis recombinant allergen (ATR, Diaskintest®) for disseminated processes in the lungs are single and contradictory.The aim. Тo study the diagnostic capabilities of intradermal test with tuberculosis recombinant allergen in disseminated lung processes of various etiologies.Methods. The analysis of archival materials of 204 patients with disseminated lung processes of various etiologies who were admitted to diagnostic departments of the N.S.Pokhvisneva Voronezh regional anti-tuberculosis dispensary in 2011 – 2019 was carried out. There were 85 (41.67%) women and 119 (58.33%) men aged 19 to 87 years. The data of im mu no - logical examination of patients using intradermal Mantoux samples with 2 TE PPD-L and with ATR were studied, and their comparative analysis was performed.Results. In disseminated pulmonary processes in tuberculosis, the proportion of individuals who respond positively to the Mantoux test was greater only in comparison with the group of people with sarcoidosis (p < 0.01) and did not significantly differ from the results in other groups of patients (p > 0.05). At the same time, the proportion of people who respond positively to a test with ATR in tuberculosis was greater than in patients with pneumonia, sarcoidosis (p < 0.01) and, to some extent, with a tumor. In healthy individuals, a lower proportion of positive reactions to ATR was established compared to the Mantoux test (p < 0.01). With active disseminated pulmonary tuberculosis, a hyperergic reaction (11.9%) was observed in the sample with ATR, which was not observed with the Mantoux test. In non-specific processes in the lungs, less often than negative reactions (p < 0.05) were detected on the sample with ATR less often than on the Mantoux test with 2 TE.Conclusion. The ATR sample compared to the Mantoux test indicates that it is appropriate to use it in the differential diagnosis of tuberculosis and non-specific lung diseases in adult patients with radiological dissemination syndrome.

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Two cases of disseminated tuberculosis after negative screening before adalimumab treatment for immune-mediated inflammatory diseases

Cited by 4 publications

References 10 publications

Dermatology practice updates in mycobacterial disease

Dermatology practice updates in mycobacterial disease

Long-term safety of adalimumab for patients with moderate-to-severe hidradenitis suppurativa

Immunological skin tests in differential diagnostics disseminated processes in the lungs

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