Two Cases of 18 F-FDG PET/CT Findings in Acinar Cell Carcinoma of the Pancreas

Takanami, Kentaro; Abe, Keiko; Mitamura, Atsushi; Miyazaki, Shukichi; Ishida, Kazuyuki; Yamada, Satoshi; Takahashi, Satoshi

doi:10.1097/rlu.0b013e31819a2076

Cited by 7 publications

(3 citation statements)

References 17 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Imaging may show variable fluorodeoxyglucose uptake in areas that appear heterogeneous with contrast enhancement on computed tomography 17. Internal calcifications and central hypodense regions are also common.…”

Section: Clinico-radiologic Characterizationmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas: Clinical and Cytomorphologic Characteristics

2013

View full text Add to dashboard Cite

Acinar cell carcinoma is a rare malignant epithelial neoplasm with predominantly exocrine acinar differentiation and is seen primarily in older men (mean age, 62 years). The presenting symptoms are usually non-specific, and jaundice is often not present. Symptoms relating to the overproduction and release of lipase into the circulation are present in 10-15% of patients. Characteristic cytomorphologic features include a population of cells with minimal pleomorphism, eccentrically placed nuclei with a single prominent nucleoli and moderate hyperchromasia. The cytoplasm is finely granular, and the background may contain granular debris secondary to cytolysis. A significant proportion of the cases also have a minor neuroendocrine component or scattered neuroendocrine cells. Approximately 50% of patients have metastatic disease at presentation, often restricted to the regional lymph nodes and liver. The prognosis is poor, only slightly better than that of pancreatic ductal adenocarcinoma.

show abstract

Section: Clinico-radiologic Characterizationmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas: Clinical and Cytomorphologic Characteristics

2013

View full text Add to dashboard Cite

show abstract

“…In PET/CT, ACC of the pancreas are likely to demonstrate a high FDG uptake [ 21 , 29 , 32 – 34 ] in line with its relative aggressiveness. But sometimes the tumors may present weak FDG activity, [ 33 , 35 , 36 ] which might be due to cystic degeneration [ 33 ] or extensive and various degrees of clear cell change. [ 36 ] In our cases, increased FDG activity was demonstrated in both of the tumors with a wide range of SUVs (SUVmax 3.5–9.4) that is consistent with the literature.…”

Section: Discussionmentioning

confidence: 99%

Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement

Luo

Hu²,

Ma³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Pancreatic acinar cell carcinoma (ACC) is a rare malignant tumor of exocrine pancreas. It is typically a well-marginated large solid mass arising in a certain aspect of the pancreas. Diffuse involvement of ACC in the pancreas is very rare, and may simulate pancreatitis in radiological findings. We report 2 cases of ACC presenting as diffuse enlargement of the pancreas due to tumor involvement without formation of a distinct mass.Patient concerns:The patients consisted of a 41-year-old man with weight loss and a 77-year-old man who was asymptomatic.Diagnoses:Computed tomography (CT) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT showed diffuse enlargement of the pancreas forming a sausage-like shape with homogenously increased FDG activity.Interventions:Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) biopsy of the pancreatic lesion was performed.Outcomes:Histopathology results from the pancreas confirmed the diagnosis of pancreatic ACC.Lessons:Because diffuse enlargement of the pancreas is a common imaging feature of pancreatitis, recognition of this rare morphologic pattern of ACC is important for radiological diagnosis of this tumor.

show abstract

“…Solid pseudopapillary neoplasm is a relatively rare low-grade malignant tumor that can occur anywhere in the pancreas 5,6 . Solid pseudopapillary neoplasm should be differentiated from acinar cell carcinoma, 7 serous cystadenoma, 8 mucinous cystadenoma, 9 and neuroendocrine tumor 10 . 68 Ga-labeled FAPI has recently been introduced as a promising tumor imaging agent 11,12 .…”

mentioning

confidence: 99%

68Ga-FAPI-04 PET/CT in the Detection of Non–FDG-Avid Solid Pseudopapillary Neoplasm of the Pancreas

et al. 2023

View full text Add to dashboard Cite

Solid pseudopapillary neoplasm of the pancreas is a rare tumor. A 46-year-old woman presented with chest pain for 6 months. Chest CT revealed a large mass of the right mediastinum. Then, she underwent 18 F-FDG and 68 Ga-FAPI-04 PET/CT scans for staging. However, we accidentally found that a non-FDG focus nodule in the body of the pancreas with elevated FAPI activity. Finally, biopsy of the nodule in the body of the pancreas confirmed the diagnosis of solid pseudopapillary neoplasm.

show abstract

Two Cases of 18 F-FDG PET/CT Findings in Acinar Cell Carcinoma of the Pancreas

Cited by 7 publications

References 17 publications

Acinar Cell Carcinoma of the Pancreas: Clinical and Cytomorphologic Characteristics

Acinar Cell Carcinoma of the Pancreas: Clinical and Cytomorphologic Characteristics

Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement

68Ga-FAPI-04 PET/CT in the Detection of Non–FDG-Avid Solid Pseudopapillary Neoplasm of the Pancreas

Contact Info

Product

Resources

About