Two birds with one stone: A multi-functional nanoplatform for sensitive detection and real-time inactivation of pathogenic bacteria with NIR-triggered PTT/PDT

Photothermal therapy (PTT) agents possess the capability to absorb light and transform it into heat, providing a promising approach for inhibiting and eradicating tumor cells. Therefore, there is a significant interest in developing novel PTT agents with superior biocompatibility and photothermal conversion efficiency. Herein, Ag2S/g-C3N4 nanoparticles (NPs) with exceptional near-infrared absorption performance were successfully synthesized using a hydrothermal method. The photothermal conversion efficiency of Ag2S/g-C3N4 NPs reached 31.28% under 808 nm laser irradiation, surpassing that of most reported PTT agents. The simultaneous application of an 808 nm laser resulted in a significant augmentation of reactive oxygen species (ROS) generation, including ·O2 – and ·OH, which, in turn, triggered apoptosis and the death of tumor cells via photodynamic therapy (PDT). The efficacy of tumor elimination was confirmed through cellular and animal experiments, demonstrating the synergistic effectiveness of PTT and PDT. Importantly, no tumor regrowth was observed for 30 days after synergistic treatment. These results highlight the potential of combining photodynamic and photothermal therapies in nanomaterials for effective tumor therapy, offering a novel approach to tumor catalytic-photothermal therapy utilizing nanomaterials.

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Au Nanorods Activate Zn²⁺/Ag⁺ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles

Zheng,

Shen,

Cheng

et al. 2024

ACS Materials Lett.

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Wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid−base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core−shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (≤40 °C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag + . Vascular endothelial growth factor expression was promoted by trace Zn 2+ , and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn 2+ /Ag + and the mild thermal impact showcases new avenues for clinical treatment.

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Two birds with one stone: A multi-functional nanoplatform for sensitive detection and real-time inactivation of pathogenic bacteria with NIR-triggered PTT/PDT

Cited by 4 publications

References 57 publications

Synthesis of activated carbon-supported nano copper oxide and its inactivation performance on Escherichia coli in water

Synthesis of activated carbon-supported nano copper oxide and its inactivation performance on Escherichia coli in water

Multifunctional Ag₂S/g-C₃N₄ Nanoparticles for Photodynamic and Photothermal Cancer Therapy under Near-Infrared Excitation

Au Nanorods Activate Zn²⁺/Ag⁺ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles

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Two birds with one stone: A multi-functional nanoplatform for sensitive detection and real-time inactivation of pathogenic bacteria with NIR-triggered PTT/PDT

Cited by 4 publications

References 57 publications

Synthesis of activated carbon-supported nano copper oxide and its inactivation performance on Escherichia coli in water

Synthesis of activated carbon-supported nano copper oxide and its inactivation performance on Escherichia coli in water

Multifunctional Ag2S/g-C3N4 Nanoparticles for Photodynamic and Photothermal Cancer Therapy under Near-Infrared Excitation

Au Nanorods Activate Zn2+/Ag+ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles

Contact Info

Product

Resources

About

Multifunctional Ag₂S/g-C₃N₄ Nanoparticles for Photodynamic and Photothermal Cancer Therapy under Near-Infrared Excitation

Au Nanorods Activate Zn²⁺/Ag⁺ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles