Two birds with one stone: SGI1 can stabilize itself and expel the IncC helper by hijacking the plasmid parABS system
Gábor Murányi,
Mónika Szabó,
Károly Acsai
et al.
Abstract:The SGI1 family integrative mobilizable elements, which are efficient agents in distribution of multidrug resistance in Gammaproteobacteria, have a complex, parasitic relationship with their IncC conjugative helper plasmids. Besides exploiting the transfer apparatus, SGI1 also hijacks IncC plasmid control mechanisms to time its own excision, replication and expression of self-encoded T4SS components, which provides advantages for SGI1 over its helpers in conjugal transfer and stable maintenance. Furthermore, S… Show more
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